1. MAPK/ERK Pathway
  2. JNK
  3. TCS JNK 5a

TCS JNK 5a (Synonyms: JNK Inhibitor IX)

Cat. No.: HY-15881 Purity: 98.91%
Handling Instructions

TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.

For research use only. We do not sell to patients.

TCS JNK 5a Chemical Structure

TCS JNK 5a Chemical Structure

CAS No. : 312917-14-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
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Description

TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.

IC50 & Target[1]

JNK3

6.7 (pIC50)

JNK2

6.5 (pIC50)

In Vitro

TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them[1].

Molecular Weight

332.42

Formula

C₂₀H₁₆N₂OS

CAS No.

312917-14-9

SMILES

O=C(C1=C2C=CC=CC2=CC=C1)NC3=C(C#N)C(CCCC4)=C4S3

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 51 mg/mL (153.42 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0082 mL 15.0412 mL 30.0824 mL
5 mM 0.6016 mL 3.0082 mL 6.0165 mL
10 mM 0.3008 mL 1.5041 mL 3.0082 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
TCS JNK 5a
Cat. No.:
HY-15881
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