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Results for "

adenine dinucleotide phosphate

" in MedChemExpress (MCE) Product Catalog:

63

Inhibitors & Agonists

1

Fluorescent Dyes

9

Biochemical Assay Reagents

10

Natural
Products

6

Isotope-Labeled Compounds

1

Oligonucleotides

1

GMP Molecules

Targets Recommended:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-B0445
    NAD+
    Maximum Cited Publications
    45 Publications Verification

    β-DPN; β-NAD; β-Nicotinamide adenine dinucleotide

    		 Endogenous Metabolite Metabolic Disease
    NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
    NAD+
  • HY-B1654
    Flavin adenine dinucleotide
    5+ Cited Publications

    FAD

    		 Endogenous Metabolite Cardiovascular Disease
    Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
    Flavin adenine dinucleotide
  • HY-B0456
    Riboflavin
    5+ Cited Publications

    Vitamin B2; E101

    		 Environmental Pollutants Endogenous Metabolite Bacterial Metabolic Disease Cancer
    Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction .
    Riboflavin
  • HY-B0445A
    NAD sodium
    40+ Cited Publications

    β-DPN sodium; β-NAD sodium; β-Nicotinamide adenine dinucleotide sodium

    		 Endogenous Metabolite Metabolic Disease
    NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .
    NAD sodium
  • HY-B1654A
    Flavin adenine dinucleotide disodium salt
    5+ Cited Publications

    FAD disodium salt; FAD-Na2

    		 Endogenous Metabolite Cardiovascular Disease
    Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
    Flavin adenine dinucleotide disodium salt
  • HY-113432
    Nudifloramide

    2PY

    		 Endogenous Metabolite PARP Metabolic Disease
    Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
    Nudifloramide
  • HY-P2804
    GAPDH, rabbit muscle
    1 Publications Verification

    GADPH; G3PDH; Glyceraldehyde phosphate dehydrogenase

    		 Endogenous Metabolite Others
    Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals .
    GAPDH, rabbit muscle
  • HY-W654288
    NAD+-d4

    β-DPN-d4; β-NAD-d4; β-Nicotinamide adenine dinucleotide-d4

    		 Isotope-Labeled Compounds Others
    NAD+-d4 is the deuterium-labeled NAD+ (HY-B0445). NAD+-d4 is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
    NAD+-d4
  • HY-150508
    MK-0159
    1 Publications Verification

    		 CD38 Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD + (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart .
    MK-0159
  • HY-B0445S
    NAD+-13C5 ammonium

    β-DPN-13C5 ammonium; β-NAD-13C5 ammonium; β-Nicotinamide adenine dinucleotide-13C5 ammonium

    		 Isotope-Labeled Compounds Metabolic Disease
    NAD+-13C5 (ammonium) is the 13C labled NAD+ (HY-B0445), with an ammonium .
    NAD+-13C5 ammonium
  • HY-131924
    Thionicotinamide adenine dinucleotide

    Thio-NAD

    		 Biochemical Assay Reagents Others
    Thionicotinamide adenine dinucleotide (Thio-NAD) is a thione-modified analog of the coenzyme nicotinamide adenine dinucleotide (NAD +). Thionicotinamide adenine dinucleotide can replace NAD + in enzymatic reactions and shift the absorption peak to 405 nM, enabling sensitive, real-time kinetic detection of enzyme activity, which is particularly suitable for high-sensitivity diagnostic cyclic detection systems .
    Thionicotinamide adenine dinucleotide
  • HY-P3185
    beta-Galactose dehydrogenase

    		Biochemical Assay Reagents Metabolic Disease
    Beta-galactose dehydrogenase is a selective catalyst for β-galactose. Under pH 8.6 conditions, beta-galactose dehydrogenase catalyzes the oxidation of β-galactose, produced by the hydrolysis of lactose by β-galactosidase, with nicotinamide adenine dinucleotide (NAD) to produce reduced nicotinamide adenine dinucleotide (NADH). Beta-galactose dehydrogenase specifically mediates this oxidation reaction for the quantitative detection of the substrate, used in the analysis of lactose concentration in samples such as breast milk .
    beta-Galactose dehydrogenase
  • HY-113472
    N-Methyl-4-pyridone-3-carboxamide

    		Drug Metabolite Others
    N-Methyl-4-pyridone-3-carboxamide (compound 4PY) is a final product of nicotinamide adenine dinucleotide (NAD) degradation .
    N-Methyl-4-pyridone-3-carboxamide
  • HY-131615
    TPC2-A1-P
    4 Publications Verification

    		 Sodium Channel Others
    TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na 2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells .
    TPC2-A1-P
  • HY-131614
    TPC2-A1-N
    5+ Cited Publications

    		 Calcium Channel Others
    TPC2-A1-N is a powerful and Ca 2+-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant Ca 2+ responses from TPC2 (EC50=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells .
    TPC2-A1-N
  • HY-B0445GL
    NAD+ (GMP Like)

    β-DPN (GMP Like); β-NAD (GMP Like); β-Nicotinamide adenine dinucleotide (GMP Like)

    		 Endogenous Metabolite Metabolic Disease
    NAD+ (GMP Like) is NAD+ (HY-B0445) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
    NAD+ (GMP Like)
  • HY-131485
    3-Acetylpyridine adenine dinucleotide, 90%

    3-APAD, 90%; 3-Acetylpyridine NAD, 90%

    		 Lactate Dehydrogenase Metabolic Disease
    3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .
    3-Acetylpyridine adenine dinucleotide, 90%
  • HY-B1654S
    Flavin adenine dinucleotide-13C5 ammonium

    FAD-13C5 ammonium

    		 Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    Flavin adenine dinucleotide- 13C5 (FAD- 13C5) ammonium is 13C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
    Flavin adenine dinucleotide-13C5 ammonium
  • HY-154924
    Thio-NADP

    S-NADP

    		 Calcium Channel Cardiovascular Disease
    Thio-NADP (S-NADP) is a nicotinic acid adenine dinucleotide phosphate (NAADP) inhibitor. Thio-NADP activates partial Ca 2+ release .
    Thio-NADP
  • HY-B0445B
    α-NAD

    α-Nicotinamide adenine dinucleotide

    		 Mitochondrial Metabolism Endogenous Metabolite Metabolic Disease
    α-NAD (α-Nicotinamide Adenine Dinucleotide) serves as a substrate for reninase, functions as an analog of β-NAD, affects the kinetics of NAD-dependent enzymes, and also plays a critical role as a cofactor in mitochondrial redox reactions .
    α-NAD
  • HY-114570
    Tiazofurin
    1 Publications Verification

    NSC 286193; Riboxamide

    		 Nucleoside Antimetabolite/Analog Orthopoxvirus Infection Neurological Disease Cancer
    Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer .
    Tiazofurin
  • HY-B1654R
    Flavin adenine dinucleotide (Standard)

    FAD (Standard)

    		 Reference Standards Endogenous Metabolite Cardiovascular Disease
    Flavin adenine dinucleotide (Standard) is the analytical standard of Flavin adenine dinucleotide. This product is intended for research and analytical applications. Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
    Flavin adenine dinucleotide (Standard)
  • HY-147342
    β-Benzamide adenine dinucleotide

    		Drug Metabolite IMPDH Cancer
    β-Benzamide adenine dinucleotide is a biologically active metabolite of benzamide riboside. β-Benzamide adenine dinucleotide is a competitive inhibitor of human NAD kinase with a Ki value of 90 μM, and inhibits human IMPDH with IC50 values of 0.787 μM and 0.884 μM for type I and type II, respectively. β-Benzamide adenine dinucleotide exhibits inhibitory activities against lactate dehydrogenase, glutamate dehydrogenase, and malate dehydrogenase. β-Benzamide adenine dinucleotide can be used for the study of chronic myelogenous leukemia .
    β-Benzamide adenine dinucleotide
  • HY-P2987
    L-Amino acid oxidase

    		Endogenous Metabolite Amino Acid Oxidase Metabolic Disease
    L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia .
    L-Amino acid oxidase
  • HY-171213
    NB-3

    		Toll-like Receptor (TLR) Neurological Disease
    NB-3 is a nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 inhibitor. NB-3 intercepts NAD hydrolysis and undergoes covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR). The resulting small-molecule ADPR adducts are highly potent and confer compelling neuroprotection in neurological injury .
    NB-3
  • HY-125863C
    Glucose-6-phosphate dehydrogenase, Bacillus sp.

    G6PD, Bacillus sp.

    		 Endogenous Metabolite Others
    Glucose-6-phosphate dehydrogenase, Bacillus sp. catalyzes the conversion of glucose-6-phosphate into 6-phosphogluconolactone, and produces reduced nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate in this process. Glucose-6-phosphate dehydrogenase, Bacillus sp. can be used in research about diabetic complications .
    Glucose-6-phosphate dehydrogenase, Bacillus sp.
  • HY-14374
    GPP78
    1 Publications Verification

    CAY10618

    		 NAMPT Autophagy Inflammation/Immunology Cancer
    GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects .
    GPP78
  • HY-B0456R
    Riboflavin (Standard)
    1 Publications Verification

    Vitamin B2 (Standard); E101 (Standard)

    		 Reference Standards Endogenous Metabolite Bacterial Metabolic Disease Cancer
    Riboflavin (Standard) is the analytical standard of Riboflavin. This product is intended for research and analytical applications. Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction .
    Riboflavin (Standard)
  • HY-W250163
    NAD+ lithium
    40+ Cited Publications

    β-DPN lithium; β-NAD lithium; β-Nicotinamide adenine dinucleotide lithium

    		 Biochemical Assay Reagents Metabolic Disease
    NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .
    NAD+ lithium
  • HY-137672A
    2',3'-Cyclic NADP disodium

    2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate

    		 Phosphodiesterase (PDE) Calcium Channel Neurological Disease
    2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.
    2',3'-Cyclic NADP disodium
  • HY-W250156
    3-Acetylpyridine adenine dinucleotide disodium

    		Biochemical Assay Reagents Others
    3-Acetylpyridine adenine dinucleotide (disodium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    3-Acetylpyridine adenine dinucleotide disodium
  • HY-113432S
    Nudifloramide-d3

    		Endogenous Metabolite PARP Metabolic Disease
    Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
    Nudifloramide-d3
  • HY-151936
    LmNADK1-IN-1

    		Bacterial Infection
    LmNADK1-IN-1 (compound MC1) is an inhibitor of nicotinamide adenine dinucleotide kinases (NADK1) from L. monocytogenes with a Ki value of 54 nM. LmNADK1-IN-1 can be used for the research of bacterial infection . LmNADK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    LmNADK1-IN-1
  • HY-E70410
    NAD Synthetase

    NAD+ Synthetase; Nicotinamide adenine dinucleotide synthetase

    		 Endogenous Metabolite Neurological Disease Metabolic Disease Cancer
    NAD synthetase is responsible for the final step in the synthesis of nicotinamide adenine dinucleotide (NAD). The Km values for NAD, ATP, and ammonia of NAD synthetase from Escherichia coli are 200 μM, 11 μM, and 0.65 μM, respectively, while the Km values for NAD, ATP, and ammonia of NAD synthetase from yeast are 170 μM, 190 μM, and 64 μM, respectively. NAD synthetase can be used for enzymatic assays to determine ATP, ammonia, urea, or creatinine, and is also suitable for enzymatic cycling methods. Additionally, NAD synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative diseases .
    NAD Synthetase
  • HY-W250154
    β-Nicotinamide adenine dinucleotide reduced dipotassium

    		Endogenous Metabolite Metabolic Disease
    β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
    β-Nicotinamide adenine dinucleotide reduced dipotassium
  • HY-E70406
    Cholesterol Dehydrogenase, Nocardia sp.

    CHDH-5

    		 Endogenous Metabolite Others
    Cholesterol Dehydrogenase, Nocardia sp. is an enzyme that uses nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NAD(P)) as its cofactor in oxidizing cholesterol to form cholest-4-en-3-one. This enzyme oxidizes the hydroxyl group at the 3 position of the sterol ring to form a ketone.
    Cholesterol Dehydrogenase, Nocardia sp.
  • HY-B0445AR
    NAD sodium (Standard)

    β-DPN sodium (Standard); β-NAD sodium (Standard); β-Nicotinamide adenine dinucleotide sodium (Standard)

    		 Endogenous Metabolite Reference Standards Metabolic Disease
    NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .
    NAD sodium (Standard)
  • HY-113432R
    Nudifloramide (Standard)

    2PY (Standard)

    		 Reference Standards Endogenous Metabolite PARP Metabolic Disease
    Nudifloramide (Standard) is the analytical standard of Nudifloramide. This product is intended for research and analytical applications. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
    Nudifloramide (Standard)
  • HY-P2940
    NADase

    		NAMPT Inflammation/Immunology
    NADase is an ectoenzyme/membrane-bound enzyme targeting nicotinamide adenine dinucleotide (NAD +). NADase regulates intracellular NAD + homeostasis by hydrolyzing NAD + into nicotinamide mononucleotide (NMN) and ADP-ribose. NADase is promising for research of autoimmune diseases (e.g., systemic sclerosis, systemic lupus erythematosus) and aging-related disorders .
    NADase
  • HY-161712
    IMPDH-IN-4

    		IMPDH Cancer
    IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers .
    IMPDH-IN-4
  • HY-175593
    M6766

    		Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Reactive Oxygen Species (ROS) Cardiovascular Disease Neurological Disease
    M6766 is a selective endoplasmic reticulum oxidoreductase 1α (ERO1α) inhibitor with an IC50 of 1.4 μM and a KD of 1.1 μM. M6766 also inhibits ERO1β with an IC50 of 7.2 μM. M6766 binds to the flavin adenine dinucleotide-binding pocket in ERO1α. M6766 inhibits granule secretion, αIIbβ3 integrin activation, Ca 2+ mobilization, and platelet aggregation. M6766 can be used for the research of neurological disease, such as ischemic stroke .
    M6766
  • HY-131485A
    3-Acetylpyridine adenine dinucleotide, 95%

    3-APAD, 95%; 3-Acetylpyridine NAD, 95%

    		 Lactate Dehydrogenase Metabolic Disease
    3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .
    3-Acetylpyridine adenine dinucleotide, 95%
  • HY-103305
    cis-Ned19

    		Fluorescent Dye Calcium Channel Others
    cis-Ned19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. cis-Ned19 localizes to lysosomes and endolysosomal vesicles, stains two-pore calcium channels and fluorescently labels NAADP receptors (Ex/Em = 365/410 nm) .
    cis-Ned19
  • HY-B0456S5
    Riboflavin-d8

    Vitamin B2-d8 ; E101-d8

    		 Isotope-Labeled Compounds Bacterial Endogenous Metabolite Metabolic Disease Cancer
    Riboflavin-d8 (Vitamin B2-d8 ) is deuterium labeled Riboflavin. Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction .
    Riboflavin-d8
  • HY-B1654AR
    Flavin adenine dinucleotide disodium salt (Standard)

    FAD disodium salt (Standard); FAD-Na2 (Standard)

    		 Reference Standards Endogenous Metabolite Cardiovascular Disease
    Flavin adenine dinucleotide (disodium salt) (Standard) is the analytical standard of Flavin adenine dinucleotide (disodium salt). This product is intended for research and analytical applications. Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
    Flavin adenine dinucleotide disodium salt (Standard)
  • HY-177842
    Liposomal NAD+

    		Liposome Metabolic Disease
    Liposomal NAD+ is a specialized delivery system that encapsulates NAD+ within tiny liposomes. These liposomes act as protective shells, enhancing the absorption and bioavailability of NAD+. NAD+ (β-Nicotinamide adenine dinucleotide), also known as Coenzym
    Liposomal NAD+
  • HY-131041
    Ned-K

    		Calcium Channel Cardiovascular Disease
    Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca 2+ oscillations in cardiomyocytes .
    Ned-K
  • HY-172919
    PDEδ/NAMPT IN-1

    		Phosphodiesterase (PDE) NAMPT Apoptosis Cancer
    PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD +), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer .
    PDEδ/NAMPT IN-1
  • HY-134280
    8-Br-NHD+

    Nicotinamide 8-Br-hypoxanthine dinucleotide

    		 Drug Derivative Others
    8-Br-NHD+ (Nicotinamide 8-Br-hypoxanthine dinucleotide) is a derivative of NAD+ (nicotinamide adenine dinucleotide) that acts as a potential substrate, competitive inhibitor or modulator of enzymes that interact with β-NAD+. 8-Br-NHD+ can be used to synthesize a cyclic ADP nucleotide (cADPR) analog .
    8-Br-NHD+
  • HY-156424
    NOX2-IN-1

    		NADPH Oxidase Inflammation/Immunology
    NOX2-IN-1 (compound 10) is an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2). NOX2-IN-1 targets the p47phox p22phox protein protein interaction with favorable binding affinities and cellular activities .
    NOX2-IN-1

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