Thio-NADP  (Synonyms: S-NADP)

Thio-NADP (S-NADP) is a nicotinic acid adenine dinucleotide phosphate (NAADP) inhibitor. Thio-NADP activates partial Ca²⁺ release^[1].

759.47

C₂₁H₂₈N₇O₁₆P₃S

19254-05-8

Solid

Light yellow to yellow

O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H]([N+]5=CC=CC(C(N)=S)=C5)[C@@H]([C@@H]4O)O)([O-])=O)(O)=O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Bizouarn T, et al. The involvement of NADP(H) binding and release in energy transduction by proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli. Biochim Biophys Acta. 1995 Apr 4;1229(1):49-58.  [Content Brief]

  [2]. Dickey D M, et al. Thio-NADP is not an antagonist of NAADP[J]. Cell biochemistry and biophysics, 1998, 28: 63-73.