NAADP 

NAADP, a nucleotide, is a Ca²⁺-mobilizing second messenger. NAADP is essential for initiation of Ca²⁺ signaling^[1][2].

NAADP (2.5-10 μM) induces Ca2+ release from acidic intracellular stores in cytotoxic T lymphocytes^[2].
NAADP (10 μM, 30 min) stimulates cytolytic granule exocytosis in cytotoxic T lymphocyte^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

744.39

C₂₁H₂₇N₆O₁₈P₃

5502-96-5

Solid

White to off-white

O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H]([N+]5=CC=CC(C(O)=O)=C5)[C@@H]([C@@H]4O)O)([O-])=O)(O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326.  [Content Brief]

  [2]. Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22(24):2331-7.  [Content Brief]

  [3]. Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137.  [Content Brief]