2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Endoplasmic Reticulum Oxidoreductase 1 (ERO1) Reactive Oxygen Species (ROS)
  4. M6766

M6766 is a selective endoplasmic reticulum oxidoreductase 1α (ERO1α) inhibitor with an IC50 of 1.4 μM and a KD of 1.1 μM. M6766 also inhibits ERO1β with an IC50 of 7.2 μM. M6766 binds to the flavin adenine dinucleotide-binding pocket in ERO1α. M6766 inhibits granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation. M6766 can be used for the research of neurological disease, such as ischemic stroke.

For research use only. We do not sell to patients.

M6766

M6766 Chemical Structure

CAS No. : 696628-90-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

M6766 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

M6766 is a selective endoplasmic reticulum oxidoreductase 1α (ERO1α) inhibitor with an IC50 of 1.4 μM and a KD of 1.1 μM. M6766 also inhibits ERO1β with an IC50 of 7.2 μM. M6766 binds to the flavin adenine dinucleotide-binding pocket in ERO1α. M6766 inhibits granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation. M6766 can be used for the research of neurological disease, such as ischemic stroke[1].

IC50 & Target[1]

ERO1α

1.4 μM (IC50)

ERO1α

1.1 μM (Kd)

In Vitro

M6766 (1-10 μM, 20 mins) inhibits FAD-enhanced ERO1α activity in a concentration-dependent manner[1].
M6766 (1-100 μM, 20 mins) does not inhibit the activities of H2O2, MAO-A and PDI[1].
M6766 (1-5 μM, 20 mins) inhibits P-selectin exposure (α-granule secretion) and αIIbβ3 integrin activation in platelets[1].
M6766 (1-5 μM, 20 mins) inhibits platelet aggregation and ATP secretion in platelets[1].
M6766 (5 μM, 20 mins) induces ROS production and increases annexin V binding in platelets[1].
M6766 (5 μM, 20 mins) inhibits CCL5 secretion from activated platelets in platelets[1].
M6766 (5 μM, 20 mins) reduces surface coverage and volume of platelet thrombi over collagen-coated surfaces[1].
M6766 (2-5 μM, 20 mins) inhibits both Ca2+ release and influx in activated platelets[1].
M6766 (5 μM, 20 mins) significantly reduces the interaction between ERO1α and STIM1 in platelets[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M6766 Related Antibodies
In Vivo

M6766 (0.3 μg/g, i,v.) attenuates platelet thrombus formation in arterial thrombosis mice[1].
M6766 (0.3 μg/g, i,v.) reduces brain damage in ischemic stroke mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Thrombosis mice models induced by FeCl3-mediated injury[1]
Dosage: 0.3 μg/g
Administration: Intravenously injection
Result: Significantly prolonged the time to occlusion (TTO) following 7% FeCl3.
Did not affect TTO after 10% FeCl3 application.
Did not prolong tail bleeding times or increase blood loss.
Animal Model: Mice models of ischemic stroke[1]
Dosage: 0.3 μg/g
Administration: Intravenously injection
Result: Decreased the Bederson score and increased grip strength.
Reduced infarct volume following focal brain ischemia.
Molecular Weight

360.44

Formula

C19H16N6S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1C(SC2=C3CCCCC3=C(C4=NC5=CC=CC=C5N42)C#N)=NN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7744 mL 13.8719 mL 27.7439 mL
5 mM 0.5549 mL 2.7744 mL 5.5488 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7744 mL 13.8719 mL 27.7439 mL 69.3597 mL
5 mM 0.5549 mL 2.7744 mL 5.5488 mL 13.8719 mL
10 mM 0.2774 mL 1.3872 mL 2.7744 mL 6.9360 mL
15 mM 0.1850 mL 0.9248 mL 1.8496 mL 4.6240 mL
20 mM 0.1387 mL 0.6936 mL 1.3872 mL 3.4680 mL
25 mM 0.1110 mL 0.5549 mL 1.1098 mL 2.7744 mL
30 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3120 mL
40 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7340 mL
50 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
60 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1560 mL
80 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8670 mL
100 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

M6766 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M6766696628-90-7M 6766M-6766Endoplasmic Reticulum Oxidoreductase 1 (ERO1)Reactive Oxygen Species (ROS)Endoplasmic Reticulum Oxidoreductase 1ERO1αERO1βαIIbβ3PlateletIschemic strokeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
M6766
Cat. No.:
HY-175593
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.