Thionicotinamide adenine dinucleotide
Based on 1 Customer Validation
Thionicotinamide adenine dinucleotide (Thio-NAD) is a thione-modified analog of the coenzyme nicotinamide adenine dinucleotide (NAD+). Thionicotinamide adenine dinucleotide can replace NAD+ in enzymatic reactions and shift the absorption peak to 405 nM, enabling sensitive, real-time kinetic detection of enzyme activity, which is particularly suitable for high-sensitivity diagnostic cyclic detection systems.
For research use only. We do not sell to patients.
- Purity: 98.99%
- CAS No.: 4090-29-3
- Formula: C21H27N7O13P2S
- Molecular Weight:679.49
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Thionicotinamide adenine dinucleotide can replace NAD+ in enzymatic reactions, shifting the absorption peak to 405 nM, thus enabling sensitive, real-time kinetic detection of enzyme activity. It is particularly suitable for high-sensitivity diagnostic cyclic detection systems[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 4090-29-3
-
Appearance Solid
-
Molecular Weight 679.49
-
Formula C21H27N7O13P2S
-
Color Light yellow to yellow
-
SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OC[C@@H](O[C@H]([C@@H]4O)[N+]5=CC(C(N)=S)=CC=C5)[C@H]4O)([O-])=O)(O)=O)O3
-
Synonyms
Thio-NAD
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 175 mg/mL (257.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Karsten WE, et al. Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD. Biochemistry. 2002;41(40):12193-12199. [Content Brief]
[2]. Iha K, et al. Ultrasensitive ELISA Developed for Diagnosis. Diagnostics (Basel). 2019;9(3):78. Published 2019 Jul 18. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4717 mL | 7.3585 mL | 14.7169 mL | 36.7923 mL |
| 5 mM | 0.2943 mL | 1.4717 mL | 2.9434 mL | 7.3585 mL | |
| 10 mM | 0.1472 mL | 0.7358 mL | 1.4717 mL | 3.6792 mL | |
| 15 mM | 0.0981 mL | 0.4906 mL | 0.9811 mL | 2.4528 mL | |
| 20 mM | 0.0736 mL | 0.3679 mL | 0.7358 mL | 1.8396 mL | |
| 25 mM | 0.0589 mL | 0.2943 mL | 0.5887 mL | 1.4717 mL | |
| 30 mM | 0.0491 mL | 0.2453 mL | 0.4906 mL | 1.2264 mL | |
| 40 mM | 0.0368 mL | 0.1840 mL | 0.3679 mL | 0.9198 mL | |
| 50 mM | 0.0294 mL | 0.1472 mL | 0.2943 mL | 0.7358 mL | |
| 60 mM | 0.0245 mL | 0.1226 mL | 0.2453 mL | 0.6132 mL | |
| 80 mM | 0.0184 mL | 0.0920 mL | 0.1840 mL | 0.4599 mL | |
| 100 mM | 0.0147 mL | 0.0736 mL | 0.1472 mL | 0.3679 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thionicotinamide adenine dinucleotide Related Classifications
HY-131924 Related Classifications
Powered by Bioz