2. Metabolic Enzyme/Protease
  3. NAMPT
  4. P7C3-S243

P7C3-S243 is a brain-penetrant P7C3 class of neuroprotective agent. P7C3-S243 augments synthesis of nicotinamide adenine dinucleotide through activation of the metabolic enzyme nicotinamide phosphoribosyltransferase. P7C3-S243 shows potent neuroprotective efficacy in parkinson’s disease mice models. P7C3-S243 can be used for the research of parkinson’s disease.

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P7C3-S243

P7C3-S243 Chemical Structure

CAS No. : 1421622-85-6

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Description

P7C3-S243 is a brain-penetrant P7C3 class of neuroprotective agent. P7C3-S243 augments synthesis of nicotinamide adenine dinucleotide through activation of the metabolic enzyme nicotinamide phosphoribosyltransferase. P7C3-S243 shows potent neuroprotective efficacy in parkinson’s disease mice models. P7C3-S243 can be used for the research of parkinson’s disease[1].

In Vivo

P7C3-S243 (10 mg/kg/day; i.p.; pre-administration for 3 days before induction and continuous administration for 7 days after induction) protects against 6-OHDA-induced dopaminergic neuron death, preserves striatal dopamine and metabolite levels, and restores normal motor behavior in a rat model of Parkinson's disease[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Long Evans (adult male, 250-300 g, unilateral stereotactic injection of 6-OHDA into right median forebrain bundle)[1]
Dosage: 10 mg/kg/day
Administration: intraperitoneal injection; daily; 7 days (with 3 days of pretreatment before 6-OHDA injection)
Result: Restored rearing ability, spontaneous locomotor activity, and reduced amphetamine-induced ipsiversive circling.
Increased survival of tyrosine hydroxylase-positive neurons in the ipsilateral substantia nigra pars.
Preserved tyrosine hydroxylase and NeuN colocalization in substantia nigra pars compacta neurons, with survival levels approximating sham-injured rats.
Significantly restored levels of striatal dopamine, DOPAC, and homovanillic acid toward normal sham-injured levels; no effect on striatal serotonin levels.
Molecular Weight

507.19

Formula

C21H18Br2FN3O
CAS No.
SMILES

FC(CN1C2=CC=C(C=C2C3=C1C=CC(Br)=C3)Br)CNC4=NC(OC)=CC=C4
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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P7C3-S243 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P7C3-S2431421622-85-6NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factor6-OHDAblood-brain barriernicotinamide adenine dinucleotidemitochondrial integritydopaminergic neuronsneuronal survivalhippocampal neuronsnicotinamide phosphoribosyltransferaseParkinson's diseaseInhibitorinhibitorinhibit

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HY-186105
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