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aglycone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bacterial (1) Cytochrome P450 (1) Endogenous Metabolite (3) HIF/HIF Prolyl-Hydroxylase (1) NF-κB (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13250B

Silvestrol aglycone (enantiomer)

Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol .

*Silvestrol aglycone* (enantiomer)**
Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol .

HY-13250

Silvestrol aglycone	Others	Cancer
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC₅₀s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity .

HY-156133

Dihydrospinosyn A aglycone

Others Others

Dihydrospinosyn A aglycone (compound 2) is a derivative of spinosyn A aglycone with a hydrolyzed C9- and C17-glycosidic bond.

Dihydrospinosyn A aglycone	Others	Others
Dihydrospinosyn A aglycone (compound 2) is a derivative of spinosyn A aglycone with a hydrolyzed C9- and C17-glycosidic bond.

HY-N11996

Aloenin aglycone	NO Synthase NF-κB	Others
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-N10257

Burnettramic acid A aglycone

Endogenous Metabolite Others

Burnettramic acid A aglycone is a fungal metabolite found in Aspergillus burnettii .

Burnettramic acid A aglycone	Endogenous Metabolite	Others
Burnettramic acid A aglycone is a fungal metabolite found in Aspergillus burnettii .

HY-106048

Bredinin aglycone 5-Hydroxy-1H-imidazole-4-carboxamide; SM-108	Nucleoside Antimetabolite/Analog	Others
Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues .

HY-N1375

Qingyangshengenin	Others	Cancer
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-121309

Doxorubicinone Adriamycin aglycone; Adriamycinone	Endogenous Metabolite	Cancer
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-N7954

Neopanaxadiol

Others Neurological Disease

Neopanaxadiol, an aglycone of protopanaxadiol type ginsenosides, has the potential for Alzheimer's disease research .
HY-N0798

20(R)-Protopanaxatriol

20(R)-APPT
Others Others

20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.
HY-N12749

16-Anhydro Digitalin

Others Cardiovascular Disease

16-Anhydro Digitalin (compound 11) is a cardiac glycoside with a 16-dehydroisosyringyl aglycone structure .
HY-N3932

Garjasmin

Others Others

Garjasmin (compound 1) is a kind of iridoid aglycone. Garjasmin can be isolated from the flowers of Gardenia jasminoides Ellis .

Neopanaxadiol	Others	Neurological Disease
Neopanaxadiol, an aglycone of protopanaxadiol type ginsenosides, has the potential for Alzheimer's disease research .

20(R)-Protopanaxatriol 20(R)-APPT	Others	Others
20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

16-Anhydro Digitalin	Others	Cardiovascular Disease
16-Anhydro Digitalin (compound 11) is a cardiac glycoside with a 16-dehydroisosyringyl aglycone structure .

Garjasmin	Others	Others
Garjasmin (compound 1) is a kind of iridoid aglycone. Garjasmin can be isolated from the flowers of Gardenia jasminoides Ellis .

HY-N3434

Kaempferol 3,7,4'-trimethyl ether	Others	Others
Kaempferol 3,7,4'-trimethyl ether is a flavonol aglycone isolated from the leaves of Siparuna gigantotepala, has antioxidant activity .

HY-N6833

Rebaudioside M	Others	Others
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M is more than 350 times sweeter than sucrose .

HY-N1098

Velutin	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway .

HY-N7497

Protoescigenin	Others	Others
Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .

HY-135738

Convicine	Others	Others
Convicine is a pyrimidine glycoside. Convicine, as well as Vicine, is the precursor of the aglycones Divicine and Isouramil. Convicine is the main factors of favism, which is a genetic condition leading to severe hemolysis after faba bean ingestion. Convicine can be isolated from the faba bean .

HY-N11975

Glycyrrhizin-6′,6′′-dimethylester	Others	Others
Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .

HY-121309S

Doxorubicinone-d3 Adriamycin aglycone-d₃; Adriamycinone-d₃	Endogenous Metabolite	Cancer
Doxorubicinone-d₃ is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone; THAP Monohydrate	Cytochrome P450 Bacterial Antibiotic	Infection Metabolic Disease
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-N11976

Glycyrrhizin-6′′-methylester	Others	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

HY-E70130

Snailase, Snail gastrointestinal	Others	Others
Snailase, Snail gastrointestinal is an enzyme mixture composed of more than 20 enzymes, which is often used for enzymatic hydrolysis of purified flavonoid glycosides. Snailase can be obtained from the digestive tract and includes cellulase, sucrase, hemicellulase, pectinase, polygalacturonase, protease, etc .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1375

Qingyangshengenin	Monophenols Classification of Application Fields Source classification Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Cancer	Others
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-N11996

Aloenin aglycone	Structural Classification Liliaceae Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants	NO Synthase NF-κB
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-N10257

Burnettramic acid A aglycone	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
Burnettramic acid A aglycone is a fungal metabolite found in Aspergillus burnettii .

HY-121309

Doxorubicinone Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-N7954

Neopanaxadiol	Panax ginseng C. A. Meyer Triterpenes Terpenoids Source classification Plants Araliaceae	Others
Neopanaxadiol, an aglycone of protopanaxadiol type ginsenosides, has the potential for Alzheimer's disease research .

HY-N0798

20(R)-Protopanaxatriol 20(R)-APPT	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	Others
20(R)-Protopanaxatriol is a natural aglycone of ginsenosides Re, Rf, Rg1, Rg2 and Rh.

HY-N12749

16-Anhydro Digitalin	Adenium obesum (Forssk.) Roem. & Schult. Apocynaceae Structural Classification Natural Products Source classification Plants	Others
16-Anhydro Digitalin (compound 11) is a cardiac glycoside with a 16-dehydroisosyringyl aglycone structure .

HY-N3932

Garjasmin	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis	Others
Garjasmin (compound 1) is a kind of iridoid aglycone. Garjasmin can be isolated from the flowers of Gardenia jasminoides Ellis .

HY-N3434

Kaempferol 3,7,4'-trimethyl ether	Flavonols Structural Classification Monophenols Flavonoids Classification of Application Fields Labiatae Source classification Vernonia amygdalina Delile Other Diseases Phenols Plants Disease Research Fields	Others
Kaempferol 3,7,4'-trimethyl ether is a flavonol aglycone isolated from the leaves of Siparuna gigantotepala, has antioxidant activity .

HY-N6833

Rebaudioside M	Structural Classification Classification of Application Fields Source classification Plants Compositae Sweeteners Food Research Trifolium hybridum L. other families Terpenoids Other Diseases Diterpenoids Disease Research Fields	Others
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M is more than 350 times sweeter than sucrose .

HY-N1098

Velutin	Flavonoids other families Microorganisms Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	HIF/HIF Prolyl-Hydroxylase
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway .

HY-N7497

Protoescigenin	Triterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	Others
Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .

HY-135738

Convicine	Structural Classification Leguminosae Source classification Plants Vicia faba L. Saccharides Monosaccharides	Others
Convicine is a pyrimidine glycoside. Convicine, as well as Vicine, is the precursor of the aglycones Divicine and Isouramil. Convicine is the main factors of favism, which is a genetic condition leading to severe hemolysis after faba bean ingestion. Convicine can be isolated from the faba bean .

HY-N11975

Glycyrrhizin-6′,6′′-dimethylester	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Umbelliferae	Others
Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone; THAP Monohydrate	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Zingiberaceae Curcuma comosa Roxb.	Cytochrome P450 Bacterial Antibiotic
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-N11976

Glycyrrhizin-6′′-methylester	Structural Classification Glycyrrhiza glabra Linn. Leguminosae Ketones, Aldehydes, Acids Source classification Plants	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

Cat. No.	Product Name	Chemical Structure

HY-121309S

Doxorubicinone-d3
Doxorubicinone-d₃ is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

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aglycone

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products