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human adenosine A3 receptor

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37

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1

Biochemical Assay Reagents

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14121
    MRS 1754
    Maximum Cited Publications
    8 Publications Verification

    		 Adenosine Receptor Metabolic Disease Inflammation/Immunology
    MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats .
    MRS 1754
  • HY-100678
    CGS 15943

    		Adenosine Receptor PI3K Inflammation/Immunology Cancer
    CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .
    CGS 15943
  • HY-103166
    PSB-603
    3 Publications Verification

    		 Adenosine Receptor Inflammation/Immunology
    PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM .
    PSB-603
  • HY-121119
    MRS 1523
    5 Publications Verification

    		 Adenosine Receptor Calcium Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons .
    MRS 1523
  • HY-103181
    N6-Cyclopentyladenosine

    CPA; UK-80882

    		 Adenosine Receptor Apoptosis Cardiovascular Disease Neurological Disease Cancer
    N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures .
    N6-Cyclopentyladenosine
  • HY-14858
    Derenofylline
    2 Publications Verification

    SLV 320

    		 Adenosine Receptor Cardiovascular Disease
    Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats .
    Derenofylline
  • HY-103186
    MRS-1706
    1 Publications Verification

    		 Adenosine Receptor Inflammation/Immunology
    MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction .
    MRS-1706
  • HY-124543
    MRS-1191
    4 Publications Verification

    		 Adenosine Receptor Neurological Disease
    MRS-1191 is a potent and selective A3 adenosine receptor antagonist with a KB value of 92 nM, a Ki value of 31.4 nM for human A3 receptor and an IC50 of 120 nM for CHO cells . MRS-1191 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MRS-1191
  • HY-103190
    MRS1220

    		Adenosine Receptor Neurological Disease Cancer
    MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system . MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo .
    MRS1220
  • HY-103174
    MRS1334

    		Adenosine Receptor Cardiovascular Disease
    MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment . MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MRS1334
  • HY-19365
    AB-MECA
    1 Publications Verification

    		 Adenosine Receptor Neurological Disease
    AB-MECA is a high affinity A3 adenosine receptor agonist with a binding Ki of 430.5 nM for human A3 receptors in CHO cells. AB-MECA can enhance plasma histamine level .
    AB-MECA
  • HY-111767
    BAY-545

    		Adenosine Receptor Inflammation/Immunology
    BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2B adenosine receptor in cells, respectively, and a Ki of 97 nM for human A2B adenosine receptor, with more selectivity over A1, A2A, and A3 adenosine receptor .
    BAY-545
  • HY-W007367
    2,6-Dichloropurine

    		Drug Intermediate Others
    2,6-Dichloropurine is a pharmaceutical intermediate. 2,6-Dichloropurine can be used to synthesize various PDE inhibitors, human A3 adenosine receptor (AR) antagonists, and CDK inhibitors .
    2,6-Dichloropurine
  • HY-103176
    PSB11 hydrochloride

    		Adenosine Receptor Others
    PSB11 hydrochloride is an antagonist with reverse excitatory activity for human A3 Adenosine Receptor with high affinity (Ki=2.3 nM) .
    PSB11 hydrochloride
  • HY-103187
    HEMADO

    		Adenosine Receptor Inflammation/Immunology Cancer
    HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype . HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    HEMADO
  • HY-110202
    MRS5698

    		Adenosine Receptor Neurological Disease Inflammation/Immunology
    MRS5698 is a selective Gi protein-coupled A3 adenosine receptor (A3AR) agonist, with Kis of approximately 3 nM for human and mouse A3AR, respectively. MRS5698 can be used for the research of pain and psoriasis .
    MRS5698
  • HY-146457
    A3AR antagonist 1

    		Adenosine Receptor Inflammation/Immunology
    A3AR antagonist 1 (compound 17) is a potent and selective human A3 adenosine receptor (AR) antagonist, with an Ki of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A3 AR even at high concentrations .
    A3AR antagonist 1
  • HY-103177
    PSB-10 hydrochloride

    		Adenosine Receptor Inflammation/Immunology
    PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice .
    PSB-10 hydrochloride
  • HY-146478
    A1/A3 AR antagonist 1

    		Adenosine Receptor Neurological Disease Inflammation/Immunology
    A1/A3 AR antagonist 1 (compound 10) is a potent adenosine 1 (A1) and adenosine 3 (A3) receptor dual antagonist with Kis of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease .
    A1/A3 AR antagonist 1
  • HY-120090
    MRS1177

    		Adenosine Receptor Inflammation/Immunology
    MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM.
    MRS1177
  • HY-118678
    MRS1186

    		Adenosine Receptor Inflammation/Immunology
    MRS1186 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 7.66 nM.
    MRS1186
  • HY-139694
    hA3AR agonist 1

    		Adenosine Receptor Others
    hA3AR agonist 1 is a potent human A3 adenosine receptor (hA3AR) agonist with a Ki value of 2.40 nM.
    hA3AR agonist 1
  • HY-12099
    A3AR antagonist 2

    		Adenosine Receptor Inflammation/Immunology
    A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM .
    A3AR antagonist 2
  • HY-164621
    A3AR antagonist 5

    		Adenosine Receptor Others
    A3AR antagonist 5 (Compound 16) is a selective antagonist for human adenosine A3 receptor with an affinity pC of 4.542 μM .
    A3AR antagonist 5
  • HY-162787
    Adenosine receptor antagonist 5

    		Adenosine Receptor Cancer
    Adenosine receptor antagonist 5 (Compound 39) is a selective antagonist for human adenosine A3 receptor (hA3R) with Ki of 12 nM. Adenosine receptor antagonist 5 inhibits IB-MECA (HY-13591)-induced cAMP accumulation in NCI-H1792 cell, inhibits the proliferation of cancer cell LK-2 and NCI-H1792. Adenosine receptor antagonist 5 exhibits a fast metabolic rate in human liver microsomes .
    Adenosine receptor antagonist 5
  • HY-14121R
    MRS 1754 (Standard)

    		Adenosine Receptor Metabolic Disease Inflammation/Immunology
    MRS 1754 (Standard) is the analytical standard of MRS 1754. This product is intended for research and analytical applications. MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats .
    MRS 1754 (Standard)
  • HY-124543R
    MRS-1191 (Standard)

    		Adenosine Receptor Neurological Disease
    MRS-1191 (Standard) is the analytical standard of MRS-1191. This product is intended for research and analytical applications. MRS-1191 is a potent and selective A3 adenosine receptor antagonist with a KB value of 92 nM, a Ki value of 31.4 nM for human A3 receptor and an IC50 of 120 nM for CHO cells . MRS-1191 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MRS-1191 (Standard)
  • HY-100678R
    CGS 15943 (Standard)

    		Reference Standards Adenosine Receptor PI3K Inflammation/Immunology Cancer
    CGS 15943 (Standard) is the analytical standard of CGS 15943. This product is intended for research and analytical applications. CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .
    CGS 15943 (Standard)
  • HY-121119R
    MRS 1523 (Standard)

    		Adenosine Receptor Calcium Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    MRS 1523 (Standard) is the analytical standard of MRS 1523. This product is intended for research and analytical applications. MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons .
    MRS 1523 (Standard)
  • HY-103186R
    MRS-1706 (Standard)

    		Reference Standards Adenosine Receptor Inflammation/Immunology
    MRS-1706 (Standard) is the analytical standard of MRS-1706. This product is intended for research and analytical applications. MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction .
    MRS-1706 (Standard)
  • HY-14858R
    Derenofylline (Standard)

    SLV 320 (Standard)

    		 Adenosine Receptor Reference Standards Cardiovascular Disease
    Derenofylline (Standard) is the analytical standard of Derenofylline. This product is intended for research and analytical applications. Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats .
    Derenofylline (Standard)
  • HY-182432
    A3AR antagonist-7

    		Adenosine Receptor Cancer
    A3AR antagonist-7 is a conjugable human A3 adenosine receptor (A3AR) antagonist with a Ki value of 31.8 nM. A3AR antagonist-7 is applicable to the research of melanoma, breast cancer and colorectal cancer .
    A3AR antagonist-7
  • HY-118232
    VUF8504

    		Adenosine Receptor Cardiovascular Disease
    VUF-8504 is a potent and selective adenosine A3 receptor antagonist with Ki value of 0.017, 14 nM for human A3, A1, respectively .
    VUF8504
  • HY-103166R
    PSB-603 (Standard)

    		Reference Standards Adenosine Receptor Inflammation/Immunology
    PSB-603 (Standard) is the analytical standard of PSB-603 (HY-103166). This product is intended for research and analytical applications. PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM .
    PSB-603 (Standard)
  • HY-103190R
    MRS1220 (Standard)

    		Reference Standards Adenosine Receptor Neurological Disease Cancer
    MRS1220 (Standard) is the analytical standard of MRS1220 (HY-103190). This product is intended for research and analytical applications. MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system . MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo .
    MRS1220 (Standard)
  • HY-103181R
    N6-Cyclopentyladenosine (Standard)

    CPA (Standard); UK-80882 (Standard)

    		 Reference Standards Adenosine Receptor Apoptosis Cardiovascular Disease Neurological Disease Cancer
    N6-Cyclopentyladenosine (Standard) is the analytical standard of N6-Cyclopentyladenosine (HY-103181). This product is intended for research and analytical applications. N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures .
    N6-Cyclopentyladenosine (Standard)
  • HY-182782
    Analgesic agent-4

    		Adenosine Receptor Neurological Disease
    Analgesic agent-4 is an adenosine A3AR ligand with analgesic/antinociceptive activity. Analgesic agent-4 inhibits writhing responses in mice and exhibits dose-dependent activity in the acetic acid (HY-Y0319)-induced mouse writhing model. Analgesic agent-4 can be used in the research of pain-related diseases .
    Analgesic agent-4

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