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Cat. No.: HY-182432

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A3AR antagonist-7

A3AR antagonist-7 is a conjugable human A3 adenosine receptor (A3AR) antagonist with a K_i value of 31.8 nM. A3AR antagonist-7 is applicable to the research of melanoma, breast cancer and colorectal cancer.

For research use only. We do not sell to patients.

CAS No.: 2672534-18-6
Formula: C₅₆H₇₁N₁₅O₁₂S₂
Molecular Weight:1210.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

A3AR antagonist-7 Chemical Structure

CAS No.: 2672534-18-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Adenosine A₃ receptor

31.8 nM (Ki)

All Adenosine Receptor Isoforms :

In Vitro

A3AR antagonist-7 (Compound 23) binds to hA₃AR expressed in CHO cells with a K_i of 31.8 nM, shows lower affinity for hA_2AAR expressed in HEK293 cells (K_i = 90 nM), and has undetermined binding to hA₁AR expressed in CHO cells, with a hA_2AAR/hA₃AR selectivity ratio of 2.83^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2672534-18-6
Molecular Weight 1210.39
Formula C₅₆H₇₁N₁₅O₁₂S₂
SMILES

O=C(C1=C(C2=C(C=CC(N)=C3S(=O)(O)=O)C3=[O+]C4=C2C=CC(N)=C4S(=O)(O)=O)C=CC(C(NCCCCCCN5N=NC(CCCC(NC6=NC7=NN(C)C=C7C8=NC(C9=CC=CO9)=NN68)=O)=C5)=O)=C1)[O-].CCN(CC)CC.CCN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Federico S, et al. Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes. Eur J Med Chem. 2020 Jan 15;186:111886.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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A3AR antagonist-7

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

A3AR antagonist-7 Related Classifications

HY-182432 Related Classifications