A3AR antagonist-7 

A3AR antagonist-7 is a conjugable human A3 adenosine receptor (A3AR) antagonist with a K_i value of 31.8 nM. A3AR antagonist-7 is applicable to the research of melanoma, breast cancer and colorectal cancer^[1].

A3AR antagonist-7 (Compound 23) binds to hA₃AR expressed in CHO cells with a K_i of 31.8 nM, shows lower affinity for hA_2AAR expressed in HEK293 cells (K_i = 90 nM), and has undetermined binding to hA₁AR expressed in CHO cells, with a hA_2AAR/hA₃AR selectivity ratio of 2.83^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1210.39

C₅₆H₇₁N₁₅O₁₂S₂

2672534-18-6

O=C(C1=C(C2=C(C=CC(N)=C3S(=O)(O)=O)C3=[O+]C4=C2C=CC(N)=C4S(=O)(O)=O)C=CC(C(NCCCCCCN5N=NC(CCCC(NC6=NC7=NN(C)C=C7C8=NC(C9=CC=CO9)=NN68)=O)=C5)=O)=C1)[O-].CCN(CC)CC.CCN(CC)CC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Federico S, et al. Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes. Eur J Med Chem. 2020 Jan 15;186:111886.
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