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Cat. No.: HY-12099

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A3AR antagonist 2

A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an K_i value of 4.54 nM.

For research use only. We do not sell to patients.

CAS No.: 1144161-05-6
Formula: C₂₂H₁₆N₆O₃
Molecular Weight:412.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

A3AR antagonist 2 Chemical Structure

CAS No.: 1144161-05-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an K_i value of 4.54 nM^[1].

IC₅₀ & Target^[1]

hA₃

4.54 nM (Ki)

All Adenosine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	36.3 nM Compound: 18	Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated cAMP accumulation Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of NECA-mediated inhibition of forskolin-stimulated cAMP accumulation	[PMID: 19301821]

Chemical Information

CAS No. 1144161-05-6
Molecular Weight 412.40
Formula C₂₂H₁₆N₆O₃
SMILES

O=C(NC1=NC2=NC=CC=C2N3C1=NN(C4=CC=C(OC)C=C4)C3=O)C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand?Receptor Modeling Studies J. Med. Chem., 2009, 52 (8), pp 2407-2419

[2]. Vittoria Colotta, et al. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies. J. Med. Chem. 2009, 52, 8, 2407-2419.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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