1. GPCR/G Protein
  2. Adenosine Receptor

MRS-1706 

Cat. No.: HY-103186
Handling Instructions

MRS-1706 is a potent and selective adenosine A2B receptor antagonist with Ki of 1.39 nM.

For research use only. We do not sell to patients.

MRS-1706 Chemical Structure

MRS-1706 Chemical Structure

CAS No. : 264622-53-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MRS-1706 is a potent and selective adenosine A2B receptor antagonist with Ki of 1.39 nM.

IC50 & Target

IC50: 1.39 nM (human adenosine A2B receptor)[1]

In Vitro

MRS-1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively[1]. Pretreatment with ZM241385 (A2A-Ado receptor antagonist) alone or in combination with MRS-1706 (A2B-Ado receptor antagonist) results in a pure constriction upon adenosine[2].

Solvent & Solubility
In Vitro: 

DMSO : 6.4 mg/mL (12.71 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9859 mL 9.9295 mL 19.8590 mL
5 mM 0.3972 mL 1.9859 mL 3.9718 mL
10 mM 0.1986 mL 0.9930 mL 1.9859 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 0.64 mg/mL (1.27 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.64 mg/mL (1.27 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.64 mg/mL (1.27 mM); Clear solution

References
Molecular Weight

503.55

Formula

C₂₇H₂₉N₅O₅

CAS No.

264622-53-9

SMILES

O=C(NC1=CC=C(C(C)=O)C=C1)COC2=CC=C(C3=NC(N(CCC)C(N(CCC)C4=O)=O)=C4N3)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
MRS-1706
Cat. No.:
HY-103186
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MRS-1706

Cat. No.: HY-103186