2. GPCR/G Protein
  3. Adenosine Receptor
  4. AB-MECA

AB-MECA 

Cat. No.: HY-19365 Purity: 98.01%
COA Handling Instructions

AB-MECA is a high affinity A3 adenosine receptor agonist with a binding Ki of 430.5 nM for human A3 receptors in CHO cells. AB-MECA can enhance plasma histamine level.

For research use only. We do not sell to patients.

AB-MECA Chemical Structure

AB-MECA Chemical Structure

CAS No. : 152918-26-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 253 In-stock
Solution
10 mM * 1 mL in DMSO USD 253 In-stock
Solid
1 mg USD 72 In-stock
5 mg USD 288 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

AB-MECA Related Antibodies

Top Publications Citing Use of Products

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AB-MECA is a high affinity A3 adenosine receptor agonist with a binding Ki of 430.5 nM for human A3 receptors in CHO cells. AB-MECA can enhance plasma histamine level[1][2][3][4].

IC50 & Target[1][2][3]

Adenosine A3 receptor

 

In Vitro

AB-MECA (1, 10, 100 μM; 24 hours) shows dose-dependent cytotoxicity in human lung cancer cell line A549[2].
[125I]AB-MECA has KD values for binding to A3 receptors in transfected CHO cells and in RBL-2H3 cells are 1.48 and 3.61 nM, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AB-MECA Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: A549 cell
Concentration: 1, 10, 100 μM
Incubation Time: 24 hours
Result: Shown dose-dependent cytotoxicity.
In Vivo

AB-MECA (3 ug/kg; iv) enhances plasma histamine level in mouse[4].
AB-MECA (0.3 mg/kg; iv) enhances antigen-induced bronchoconstriction in male albino guinea pigs, weighing 180-220 g[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c mice, weighing 18-25 g[4]
Dosage: 3 ug/kg
Administration: IV; single dose
Result: Induced a 5.9-fold increase in histamine levels in murine plasma.
Molecular Weight

399.40

Appearance

Solid

Formula

C18H21N7O4
CAS No.
SMILES

O[C@H]1[C@H](N2C=NC3=C(NCC4=CC=C(N)C=C4)N=CN=C23)O[C@H](C(NC)=O)[C@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (137.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5038 mL 12.5188 mL 25.0376 mL
5 mM 0.5008 mL 2.5038 mL 5.0075 mL
10 mM 0.2504 mL 1.2519 mL 2.5038 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.75 mg/mL (6.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.75 mg/mL (6.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.75 mg/mL (6.89 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.01%

COA (250 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References
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AB-MECA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AB-MECA152918-26-8Adenosine ReceptorP1 receptorA3 adenosine receptorCHO cellshistamineA549bronchoconstrictionInhibitorinhibitorinhibit

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