2. GPCR/G Protein
  3. Adenosine Receptor
  4. Analgesic agent-4

Analgesic agent-4 is an adenosine A3AR ligand with analgesic/antinociceptive activity. Analgesic agent-4 inhibits writhing responses in mice and exhibits dose-dependent activity in the acetic acid (HY-Y0319)-induced mouse writhing model. Analgesic agent-4 can be used in the research of pain-related diseases.

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Analgesic agent-4

Analgesic agent-4 Chemical Structure

CAS No. : 1179703-17-3

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Analgesic agent-4 Related Antibodies

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Description

Analgesic agent-4 is an adenosine A3AR ligand with analgesic/antinociceptive activity. Analgesic agent-4 inhibits writhing responses in mice and exhibits dose-dependent activity in the acetic acid (HY-Y0319)-induced mouse writhing model. Analgesic agent-4 can be used in the research of pain-related diseases[1].

In Vitro

Analgesic agent‑4 (Compound 37) can bind to the human adenosine A3 receptor, and this binding relies on conserved and enhanced hydrophobic interactions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Analgesic agent-4 Related Antibodies
In Vivo

Analgesic agent-4 (3-300 mg/kg; subcutaneous injection; single administration) exhibits analgesic activity in the mouse writhing model induced by Acetic acid (HY-Y0319)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice treated Acetic acid (HY-Y0319)[1]
Dosage: 3-300 mg/kg
Administration: s.c.; single dose
Result: Produced a 47% writhing inhibition rate at 100 mg/kg.
Inhibited writhing in a dose-dependent manner within the range of 30-300 mg/kg.
Molecular Weight

249.65

Formula

C11H8ClN3O2
CAS No.
SMILES

OC(C=C1)=CC=C1NC(C2=CC=C(Cl)N=N2)=O
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Purity & Documentation
References
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Analgesic agent-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Analgesic agent-41179703-17-3Analgesic agent4Analgesic agent 4Adenosine ReceptorP1 receptorhuman adenosine A3 receptorpain-related disordersMD simulationsacetic acid-induced writhing mouse modelsadenosine A3 receptorA3ARmiceInhibitorinhibitorinhibit

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