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Results for "

imidazole compound

" in MedChemExpress (MCE) Product Catalog:

52

Inhibitors & Agonists

11

Biochemical Assay Reagents

2

Natural
Products

7

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0837
    Imidazole
    2 Publications Verification

    Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

    		 MOFs Ser/Thr Protease Thrombopoietin Receptor Neurological Disease Inflammation/Immunology
    Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
    Imidazole
  • HY-10882
    Clotrimazole
    Maximum Cited Publications
    9 Publications Verification

    		 Fungal Bacterial Autophagy Antibiotic Infection Cancer
    Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
    Clotrimazole
  • HY-W007695
    1H-Imidazole-4-carboxylic acid

    4-imidazolecarboxylic acid

    		 Biochemical Assay Reagents Others
    1H-Imidazole-4-carboxylic acid is an organic compound containing an imidazole ring and a carboxyl group. 1H-Imidazole-4-carboxylic acid stabilizes specific forms of metal ions through coordination, thus influencing the progress of chemical reactions. 1H-Imidazole-4-carboxylic acid plays an important role in the hydrolysis of phosphate esters catalyzed by lanthanide metals. 1H-Imidazole-4-carboxylic acid can be used to modify dendrimers, changing the surface properties and catalytic performance of materials .
    1H-Imidazole-4-carboxylic acid
  • HY-W007321
    1H-Imidazole-2-carbaldehyde

    2-Formylimidazole

    		 Biochemical Assay Reagents Others
    1H-Imidazole-2-carbaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1H-Imidazole-2-carbaldehyde
  • HY-ER010
    1H-Imidazole hydrochloride

    imidazole hydrochloride

    		 Biochemical Assay Reagents Others
    1H-Imidazole hydrochloride can be used as ligand, buffer and catalyst, etc., and also plays an important role in the process of drug synthesis and extraction of natural products. In addition, the compound is widely used in certain industrial fields, such as in the manufacturing process of plastics, coatings, textiles and electronic materials. Although the compound has no direct medical applications, it plays an important role in chemical research and laboratory studies.
    1H-Imidazole hydrochloride
  • HY-129966
    PROTAC IRAK4 degrader-1
    1 Publications Verification

    		 PROTACs IRAK Cancer
    PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon-based IRAK4 PROTAC. PROTAC IRAK4 degrader-1 is composed of IRAK4 ligand (red part) PROTAC IRAK4 ligand-1 (HY-129967), E3 ligase ligand (blue part) Pomalidomide (HY-10984), and PROTAC linker (black part) AM-Imidazole-PA-Boc (HY-129968) .
    PROTAC IRAK4 degrader-1
  • HY-W010372
    1-Methylbenzimidazole

    		Biochemical Assay Reagents Others
    1-Methylbenzimidazole is an imidazole compound. 1-Methylbenzimidazole functions as an electrolyte additive in dye-sensitized solar cells. 1-Methylbenzimidazole is promising for research of solar cell performance .
    1-Methylbenzimidazole
  • HY-59303
    1H-Imidazole-5-carboxaldehyde

    		Biochemical Assay Reagents Others
    1H-Imidazole-5-carboxaldehyde can be used as a chemical reagent in organic synthesis reactions. 1H-Imidazole-5-carboxaldehyde can be used to prepare other imidazole compounds, such as imidazole pyrimidine and imidazolone. 1H-Imidazole-5-carboxaldehyde can also be used as biochemical dyes and fluorescent probes.
    1H-Imidazole-5-carboxaldehyde
  • HY-W017511
    5,6-Dimethyl-1H-benzo[d]imidazole

    		Endogenous Metabolite Drug Intermediate Others
    5,6-Dimethyl-1H-benzo[d]imidazole is an endogenous metabolite. 5,6-Dimethyl-1H-benzo[d]imidazole is also a benzimidazole derivative and can be used in the synthesis of other active compounds .
    5,6-Dimethyl-1H-benzo[d]imidazole
  • HY-144034
    GLP-1R agonist 3

    		GLP Receptor Metabolic Disease
    GLP-1R agonist 3 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1) .
    GLP-1R agonist 3
  • HY-W042985
    1-Benzylimidazole
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    1-Benzyl-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1-Benzylimidazole
  • HY-W002226
    4-Bromo-1H-imidazole

    		Biochemical Assay Reagents Others
    4-Bromo-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-Bromo-1H-imidazole
  • HY-10882S
    Clotrimazole-d5

    		Isotope-Labeled Compounds Fungal Bacterial Autophagy Antibiotic Infection Cancer
    Clotrimazole-d5 is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity .
    Clotrimazole-d5
  • HY-77049
    1-Trityl-1H-imidazole-4-carbaldehyde

    4-Formyl-1-tritylimidazole

    		 Biochemical Assay Reagents Others
    1-Trityl-1H-imidazole-4-carbaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1-Trityl-1H-imidazole-4-carbaldehyde
  • HY-W366691
    4-Hydroxy-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide

    		Drug Intermediate Others
    4-Hydroxy-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide is a drug intermediate for synthesis of various active compounds.
    4-Hydroxy-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide
  • HY-42850
    5-Chloromethyl-1-propyl-1H-imidazole hydrochloride

    		Drug Intermediate Others
    5-Chloromethyl-1-propyl-1H-imidazole hydrochloride is a drug intermediate for synthesis of various active compounds.
    5-Chloromethyl-1-propyl-1H-imidazole hydrochloride
  • HY-44924
    1-Benzyl-2-methyl-1H-imidazole-5-carbaldehyde

    		Drug Intermediate Others
    1-Benzyl-2-methyl-1H-imidazole-5-carbaldehyde is a drug intermediate for synthesis of various active compounds.
    1-Benzyl-2-methyl-1H-imidazole-5-carbaldehyde
  • HY-47848
    1-Benzyl-4-hydroxy-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide

    		Drug Intermediate Others
    1-Benzyl-4-hydroxy-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide is a drug intermediate for synthesis of various active compounds.
    1-Benzyl-4-hydroxy-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide
  • HY-78066
    Abemaciclib Impurity 1

    6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

    		 Drug Intermediate Others
    Abemaciclib Impurity 1 (6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole) is a drug intermediate for synthesis of various active compounds.
    Abemaciclib Impurity 1
  • HY-144650
    Hsp90-Cdc37-IN-3

    		Apoptosis HSP Cancer
    Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol−imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits Hsp90−Cdc37 by covalent-binding, and induces apoptosis .
    Hsp90-Cdc37-IN-3
  • HY-D0837R
    Imidazole (Standard)

    Glyoxaline (Standard); 1,3-Diaza-2,4-cyclopentadiene (Standard)

    		 Xanthine Oxidase Reference Standards Ser/Thr Protease Thrombopoietin Receptor Neurological Disease Inflammation/Immunology
    Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
    Imidazole (Standard)
  • HY-W764737
    Methylboronic acid pinacol ester-d3

    		Isotope-Labeled Compounds Cancer
    Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .
    Methylboronic acid pinacol ester-d3
  • HY-65067
    2,4-Dimethyl-1H-imidazole-5-carbaldehyde

    		Drug Intermediate Others
    2,4-Dimethyl-1H-imidazole-5-carbaldehyde is a drug intermediate for synthesis of various active compounds.
    2,4-Dimethyl-1H-imidazole-5-carbaldehyde
  • HY-W002802
    4-Iodo-1H-imidazole

    5-Iodo-1H-imidazole

    		 Biochemical Assay Reagents Others
    4-Iodo-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-Iodo-1H-imidazole
  • HY-10882R
    Clotrimazole (Standard)

    		Reference Standards Fungal Bacterial Autophagy Antibiotic Infection Cancer
    Clotrimazole (Standard) is the analytical standard of Clotrimazole. This product is intended for research and analytical applications. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
    Clotrimazole (Standard)
  • HY-178048
    Neuroprotective agent 13

    		Autophagy Neurological Disease
    Neuroprotective agent 13 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 13 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 13 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs) .
    Neuroprotective agent 13
  • HY-144033
    GLP-1R agonist 1

    		GCGR Metabolic Disease
    GLP-1R agonist 1 is a potent agonist of GLP-1R. GLP-1R agonist 1 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 1 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 4) .
    GLP-1R agonist 1
  • HY-174170
    (S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide

    		STING Cancer
    (S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing a key amide benzimidazole (ABZI) component and shows reproducible inhibition of 3H-cGAMP binding to STING with an apparent inhibition constant IC50 of 14 μM. (S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide can be used for tumor research .
    (S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide
  • HY-W699983
    Imidazole-15N2

    Glyoxaline-15N2; 1,3-Diaza-2,4-cyclopentadiene-15N2

    		 Isotope-Labeled Compounds Thrombopoietin Receptor Ser/Thr Protease Xanthine Oxidase Neurological Disease Inflammation/Immunology
    Imidazole- 15N2 (Glyoxaline- 15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
    Imidazole-15N2
  • HY-W017511R
    5,6-Dimethyl-1H-benzo[d]imidazole (Standard)

    		Reference Standards Endogenous Metabolite Drug Intermediate Others
    5,6-Dimethyl-1H-benzo[d]imidazole (Standard) is the analytical standard of 5,6-Dimethyl-1H-benzo[d]imidazole (HY-W017511). This product is intended for research and analytical applications. 5,6-Dimethyl-1H-benzo[d]imidazole is an endogenous metabolite. 5,6-Dimethyl-1H-benzo[d]imidazole is also a benzimidazole derivative and can be used in the synthesis of other active compounds.
    5,6-Dimethyl-1H-benzo[d]imidazole (Standard)
  • HY-155712
    Antifungal agent 70

    		Fungal Infection
    Antifungal agent 70 (compound 13) is a dihydroeugenol-imidazole against multi-resistant Candida auris (MIC: 36.4 μM). Antifungal agent 70 shows antifungal activity .
    Antifungal agent 70
  • HY-10882S1
    Clotrimazole-d10

    		Antibiotic Bacterial Autophagy Fungal Isotope-Labeled Compounds Infection Cancer
    Clotrimazole-d10 is deuterated labeled Clotrimazole (HY-10882). Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
    Clotrimazole-d10
  • HY-155709
    Antifungal agent 67

    		Fungal Infection
    Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts .
    Antifungal agent 67
  • HY-155711
    Antifungal agent 69

    		Fungal Infection
    Antifungal agent 69 (compound 13) is a eugenol-imidazole against Candida albicans (MIC: 4.6 μM) with no relevant cytotoxicity. Antifungal agent 69 alters the fungal ergosterol biosynthesis and shows antifungal activity .
    Antifungal agent 69
  • HY-150691
    SARS 3CLpro-IN-1

    		SARS-CoV Cancer
    SARS 3CLpro-IN-1 (Compound 3b) is a SARS 3CL protease inhibitor with an IC50 value of 95 μM, as a specific stereo isomer of the octahydroisochromene scaffold, directs the P1 site imidazole .
    SARS 3CLpro-IN-1
  • HY-161271
    MLK-IN-2

    		Mixed Lineage Kinase Neurological Disease Cancer
    MLK-IN-2 (Compound 9a) is a Mixed Lineage Kinase 3 (MLK3) inhibitor containing 3H-imidazole [4,5-b] pyridine structure. IC50 value is 6 nM. MLK-IN-2 can be used to study cancer and neurodegenerative diseases .
    MLK-IN-2
  • HY-119427
    Anti-melanoma agent 3

    		Microtubule/Tubulin Cancer
    Anti-melanoma agent 3 (compound 5cb) is a 2-aryl-4-benzoyl-imidazole (ABI) derivative and an inhibitor of melanoma xenogeneic tumors. Anti-melanoma agent 3 exerts anticancer activity by interacting with the colchicine binding site to inhibit tubulin polymerization .
    Anti-melanoma agent 3
  • HY-115905
    Antimalarial agent 9

    		Parasite Infection
    Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC50-0.14 μM) and MDR strain (IC50-0.41 μM) with minimal cytotoxicity and high selectivity .
    Antimalarial agent 9
  • HY-155710
    Antifungal agent 68

    		Fungal Infection
    Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
    Antifungal agent 68
  • HY-122157
    YM-534

    		DNA/RNA Synthesis Cancer
    YM-534, an imidazole compound, is an anti-cancer agent. YM-534 inhibits HL-60 cells with an IC50 of 2.5 μM. YM-534 retards the processing of preribosomal to ribosomal RNA of HL-60 cells. YM-534 can be used for the study of promyelocytic leukemia .
    YM-534
  • HY-178052
    Neuroprotective agent 14

    		Autophagy Neurological Disease
    Neuroprotective agent 14 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 14 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 14 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs) .
    Neuroprotective agent 14
  • HY-120550
    RS 49676

    		Parasite Infection
    RS 49676 is an N-substituted imidazole compound that exhibits strong in vitro activity against endogenous amoebae (ED50 < 0.1 ng/mL), but is ineffective against exogenous amoebae (epimastigotes). In vivo, RS 49676 (100 mg/kg/d, sc, 2 times) can prolong the average survival time of mice infected with Trypanosoma cruzi to more than 11 weeks.
    RS 49676
  • HY-177557
    IDO-IN-19

    		Indoleamine 2,3-Dioxygenase (IDO) Infection Neurological Disease Inflammation/Immunology Cancer
    IDO-IN-19 (Compound I) is a free base of an imidazole-isoindole derivative. IDO-IN-19 can inhibit the activity of Indoleamine 2,3-Dioxygenase (IDO). IDO-IN-19 can block the decomposition of tryptophan and restore the function of T cells. IDO-IN-19 can be used for the researches of cancer, immunology, infection and neurological disease, such as breast cancer and Alzheimer's disease .
    IDO-IN-19
  • HY-W422288
    (Rac)-Ketoconazole

    (Rac)-Ketoconazol; (Rac)-R 41400

    		 Fungal Cytochrome P450 Infection
    (Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections .
    (Rac)-Ketoconazole
  • HY-161153
    Microtubule inhibitor 9

    		Apoptosis Cancer
    Microtubule inhibitor 9 (Compound O-7) is a 2-Aryl-1H-benzo [d] imidazole derivative with in vitro anticancer activity. Microtubule inhibitor 9 can induce cell cycle arrest at the G2/M phase and early apoptosis. Microtubule inhibitor 9 inhibits cancer cell migration by inhibiting wound healing and colony formation .
    Microtubule inhibitor 9
  • HY-107564
    Impentamine dihydrobromide

    VUF 4702 dihydrobromide

    		 Histamine Receptor Inflammation/Immunology
    Impentamine dihydrobromide (VUF 4702 dihydrobromide) is a histamine H3 receptor antagonist with potential antihistamine activity. Impentamine dihydrobromide shows the strongest selective H3 antagonism among a series of 4(5)-(ω-aminoalkyl)-1H-imidazole compounds. The pA2 value of impentamine dihydrobromide is 8.4, showing its high efficacy in guinea pig jejunum. Impentamine dihydrobromide has a specific antagonistic binding site with the H3 receptor .
    Impentamine dihydrobromide
  • HY-118185
    SQ 31844

    		Renin Others
    SQ 31844 is a novel renin inhibitor belonging to the imidazolidinol class. This compound, which contains an imidazole ring in its active site binding group, has potent in vitro inhibition of primate renin, but not rat, pig, or dog renin. In conscious, sodium-deprived cynomolgus monkeys, both compounds produced dose-related inhibition of plasma renin activity (PRA) over a dose range of 0.001 to 1.0 μmol/kg, administered intravenously, with complete inhibition observed at the highest dose. However, a reduction in blood pressure was only observed when 10 μmol/kg was administered intravenously or by infusion. In sodium-replete monkeys, SQ 30774 inhibited the increase in arterial blood pressure and PRA following administration of exogenous monkey renin. When the compounds were administered orally at 50 μmol/kg, only SQ 31844 significantly inhibited PRA (80%). In summary, the imidazolidinol renin inhibitors have potent inhibitory effects on renin in vitro and inhibit PRA and reduce arterial blood pressure in vivo.
    SQ 31844
  • HY-W705408
    1H-Imidazole-5-carboxaldehyde-15N2

    		Isotope-Labeled Compounds Biochemical Assay Reagents Others
    1H-Imidazole-5-carboxaldehyde- 15N2 is the 15N-labeled 1H-Imidazole-5-carboxaldehyde (HY-59303). 1H-Imidazole-5-carboxaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1H-Imidazole-5-carboxaldehyde-15N2
  • HY-50849
    1-(4-Ethynyl-2-methoxyphenyl)-4-methyl-1H-Imidazole

    		Drug Intermediate Others
    1-(4-Ethynyl-2-methoxyphenyl)-4-methyl-1H-Imidazole is a drug intermediate for synthesis of various active compounds.
    1-(4-Ethynyl-2-methoxyphenyl)-4-methyl-1H-Imidazole
  • HY-W030824
    1,2-Dimethyl-1H-imidazole-4-sulfonyl chloride

    		Biochemical Assay Reagents Others
    1,2-Dimethyl-1H-imidazole-4-sulfonyl chloride is a kind of biological materials or organic compounds that are widely used in life science research.
    1,2-Dimethyl-1H-imidazole-4-sulfonyl chloride

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