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Cat. No.: HY-178052

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Neuroprotective agent 14

Neuroprotective agent 14 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 14 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 14 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs).

For research use only. We do not sell to patients.

CAS No.: 3086460-57-0
Formula: C₁₆H₁₃F₃N₂O
Molecular Weight:306.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Neuroprotective agent 14 Chemical Structure

CAS No.: 3086460-57-0

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Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Neuroprotective agent 14 (Compound 38b) (10 μM, 24 h) enhances the viability of pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) with CLN3, with a maximum protective effect of 73.68 %^[1].
Neuroprotective agent 14 (10 μM, 24 h) clears the abnormal accumulation of subunit c of mitochondrial ATP synthase (SCMAS) in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 14 (10 μM, 24 h) activates the autophagic pathway in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 14 (1-10 μM) does not activate Kv7.2/7.3 voltage-gated potassium channels^[1].
Neuroprotective agent 14 shows potential to cross the blood-brain barrier with 96.25% binding in mouse brain homogenate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

IPSC-NPC cells with CLN3
Concentration:

10 μM
Incubation Time:

24 h
Result:

Increased the immunofluorescence of autophagic cells.

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-∞	T_1/2	CL/F	MRT_0-∞	V_ss	T_max	F
Mice^[1]	1 mg/kg	i.v.	4542 ng/mL	3803.3 ng·h/mL	6.04 h	0.27 L/h/kg	1.54	0.4 L/kg	/	/
Mice^[1]	10 mg/kg	p.o.	5892 ng/mL	13244.5 ng·h/mL	6.75 h	0.76 L/h/kg	4.04	/	0.25 h	34.8 %

In Vivo

Neuroprotective agent 14 (Compound 38b) (1 mg/kg for i.v., 10 mg/kg for p.o.) shows high brain penetration, with the brain/plasma concentration ratio of 3.2 and 4.5 in Balb/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3086460-57-0
Molecular Weight 306.28
Formula C₁₆H₁₃F₃N₂O
SMILES

CC1=NC2=C(C=C(C=C2)OCC3=CC=C(C=C3)C(F)(F)F)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Simeon P, et al. Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model. J Med Chem. 2025 Sep 11;68(17):18530-18552. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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