country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-178048

Copy Link Print Information

Neuroprotective agent 13

Neuroprotective agent 13 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 13 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 13 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3086460-35-4
Fòrmula: C₁₆H₁₄F₃N₃O
Peso molecular:321.30

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Neuroprotective agent 13 Chemical Structure

No. CAS: 3086460-35-4

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

Neuroprotective agent 13 (Compound 9b) (10 μM, 24 h) significantly protects the viability of neural progenitor cells (NPCs) with CLN3 induced pluripotent stem cells (iPSCs), with a cell viability of 132.18%^[1].
Neuroprotective agent 13 (Compound 9b) clears the abnormal accumulation of subunit c of mitochondrial ATP synthase (SCMAS) in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 13 (10 μM, 24 h) activates the autophagic pathway in iPSC-NPC cells with CLN3^[1].
Neuroprotective agent 13 (1-10 μM) does not activate Kv7.2/7.3 voltage-gated potassium channels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

IPSC-NPC cells with CLN3
Concentration:

10 μM
Incubation Time:

24 h
Result:

Increased the immunofluorescence of autophagic cells.

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-∞	T_1/2	CL/F	MRT_0-∞	V_ss	F
Mice^[1]	1 mg/kg	i.v.	0.25 h	378 ng/mL	482.43 ng·h/mL	5.43 h	3.66 L/h/kg	1.09 h	3.96 L/kg	/
Mice^[1]	10 mg/kg	p.o.	0.49 h	1793.4 ng/mL	2728.03 ng·h/mL	3.6 h	3.67 L/h/kg	1.93 h	/	56.5 %

In Vivo

Neuroprotective agent 13 (Compound 9b) (1 mg/kg for i.v., 10 mg/kg for p.o.) shows high brain penetration, with the brain/plasma concentration ratio of 3.5 and 5.6 in Balb/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 3086460-35-4
Peso molecular 321.30
Fòrmula C₁₆H₁₄F₃N₃O
SMILES

OCC1=NC2=C(C=C(C=C2)NCC3=CC=C(C=C3)C(F)(F)F)N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Simeon P, et al. Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model. J Med Chem. 2025 Sep 11;68(17):18530-18552. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Neuroprotective agent 13

100 mg Obtener un presupuesto

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Neuroprotective agent 13

Actividad biológica

Descripciòn

In Vitro

Parmacokinetics

In Vivo

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Neuroprotective agent 13 Related Classifications

HY-178048 Related Classifications

Bioz

Keywords

Your Recently Viewed Products