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Cat. No.: HY-119427

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Anti-melanoma agent 3

Anti-melanoma agent 3 (compound 5cb) is a 2-aryl-4-benzoyl-imidazole (ABI) derivative and an inhibitor of melanoma xenogeneic tumors. Anti-melanoma agent 3 exerts anticancer activity by interacting with the colchicine binding site to inhibit tubulin polymerization.

For research use only. We do not sell to patients.

CAS No.: 1253697-49-2
Formula: C₁₇H₁₃FN₂O₂
Molecular Weight:296.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Anti-melanoma agent 3 Chemical Structure

CAS No.: 1253697-49-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	31 nM Compound: 5cb	Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
B16-F1	IC₅₀	63 nM Compound: 5cb	Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
DU-145	IC₅₀	41 nM Compound: 5cb	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
LNCaP	IC₅₀	28 nM Compound: 5cb	Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
MDA-MB-435	IC₅₀	1.3 nM Compound: 5cb	Resistance index, ratio of IC50 for human multidrug-resistant MDA-MB-435/LCCMDR1 cells to IC50 for human MDA-MB-435 cells Resistance index, ratio of IC50 for human multidrug-resistant MDA-MB-435/LCCMDR1 cells to IC50 for human MDA-MB-435 cells	[PMID: 20919720]
MDA-MB-435	IC₅₀	30 nM Compound: 5cb	Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
PC-3	IC₅₀	31 nM Compound: 5cb	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
PPC-1	IC₅₀	29 nM Compound: 5cb	Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
WM164	IC₅₀	28 nM Compound: 5cb	Cytotoxicity against human WM164 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human WM164 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]

In Vitro

Anti-melanoma agent 3 has anti-proliferative activity and can inhibit the growth of melanoma cell lines and prostate cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-melanoma agent 3 (10, 30 mg/kg; ip; once a day for 14 days) can significantly inhibit tumor growth in B16-F1 tumor-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1253697-49-2
Molecular Weight 296.30
Formula C₁₇H₁₃FN₂O₂
SMILES

O=C(C1=CC=C(F)C=C1)C2=CN=C(C3=CC=C(OC)C=C3)N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen J, et al. Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J Med Chem. 2010 Oct 28;53(20):7414-27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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