porcine pancreatic lipase

By Targets:	Lipase (10) Amylases (1) Angiotensin-converting Enzyme (ACE) (1) ATP Synthase (1) Biochemical Assay Reagents (1) Dipeptidyl Peptidase (1) Drug Derivative (1) GLUT (1) Glycosidase (2) NF-κB (1) NOD-like Receptor (NLR) (1) P2Y Receptor (1) p38 MAPK (1) PPAR (1) Pyroptosis (1) SARS-CoV (1) SOD (1)
By Research Areas:	Infection (1) Inflammation/Immunology (1) Metabolic Disease (6)

Targets Recommended: Lipase DAGL MAGL Hormone-Sensitive Lipase (HSL) ATGL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013168

4-Nitrophenyl palmitate 4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp	Lipase	Others
4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate) is a chromogenic substrate for lipases and esterases. Upon enzymatic hydrolysis, 4-Nitrophenyl palmitate releases p-nitrophenol, which can be quantified by colorimetric detection at 410 nm as a measure of enzymatic activity. 4-Nitrophenyl palmitate is used to characterize the activity of various bacterial and mammalian enzymes, including those from Burkholderia and porcine pancreatic lipase .

HY-126411

Peonidin-3-O-galactoside chloride	Lipase ATP Synthase	Others
Peonidin-3-O-galactoside chloride is an anthocyanin with antioxidant properties and blood-brain barrier permeability. Peonidin-3-O-galactoside chloride inhibits pancreatic lipase, with an IC₅₀ value of 23.2 μg/mL against porcine pancreatic lipase. Peonidin-3-O-galactoside chloride mediates neuroprotection, regulates glucose metabolism, protects cells from high glucose-induced damage, promotes glucose uptake and increases ATP production. Peonidin-3-O-galactoside (chloride) can be used in the research of obesity and neurodegenerative diseases .

HY-N8599

Cichoriin 2 Publications Verification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB	Infection Metabolic Disease Inflammation/Immunology
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀ = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

HY-119741

Salacinol	Glycosidase Lipase	Metabolic Disease
Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .

HY-W127391

1,2-Dilaurin (Rac)-1,2-Didodecanoylglycerol	Biochemical Assay Reagents	Others
1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

HY-N7163

(2S)-5,7,3',5'-Tetrahydroxyflavanone (2S)-3',5,5'7-Tetrahydroxyflavanone	Lipase	Others
(2S)-5,7,3',5'-Tetrahydroxyflavanone ((2S)-3',5,5'7-Tetrahydroxyflavanone) is a porcine pancreatic lipase modulator with an IC₅₀ of >200 μM against porcine pancreatic lipase. (2S)-5,7,3',5'-Tetrahydroxyflavanone interacts with an enzyme involved in triglyceride hydrolysis .

HY-N17567

Morusalnol A	Lipase	Metabolic Disease
Morusalnol A is a arylbenzofuran derivative found in the root bark of Morus alba. Morusalnol A is a **pancreatic lipase** inhibitor with a porcine pancreatic lipase IC₅₀ of 0.71 μM. Morusalnol A inhibits pancreatic lipase activity. Morusalnol A can be used for the research of obesity .

HY-N8362

1-Isomangostin	Lipase	Metabolic Disease
1-Isomangostin is an inhibitor of **pancreatic lipase*. 1-Isomangostin inhibits porcine* pancreatic lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N17876

Royleanonic acid	Lipase	Metabolic Disease
Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L. Royleanonic acid is a **porcine pancreatic lipase inhibitor with an IC₅₀** of 35 μg/mL .

HY-N11721

5-Hydroxyaloin A	SOD Lipase	Metabolic Disease
5-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at lipase’s active site and SOD’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity .

HY-N19783

Carambolaside M	Drug Derivative	Others
Carambolaside M acts as an ABTS radical cation scavenger. Carambolaside M scavenges ABTS radical cations. Carambolaside M is isolated from the fresh sweet fruits of Averrhoa carambola L., a plant belonging to the genus Averrhoa in the Oxalidaceae family .

HY-W719455

Pungenin	Lipase	Others
Pungenin is a compound that can be isolated from Leontopodium leontopodioides. Pungenin exhibits lipase inhibitory activity. Pungenin reuduces triglyceride absorption .

Cat. No.	Product Name	Type

HY-W013168

4-Nitrophenyl palmitate 4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp	Fluorescent Dyes
4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate) is a chromogenic substrate for lipases and esterases. Upon enzymatic hydrolysis, 4-Nitrophenyl palmitate releases p-nitrophenol, which can be quantified by colorimetric detection at 410 nm as a measure of enzymatic activity. 4-Nitrophenyl palmitate is used to characterize the activity of various bacterial and mammalian enzymes, including those from Burkholderia and porcine pancreatic lipase .

4-Nitrophenyl palmitate

4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp

Fluorescent Dyes

4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate) is a chromogenic substrate for lipases and esterases. Upon enzymatic hydrolysis, 4-Nitrophenyl palmitate releases p-nitrophenol, which can be quantified by colorimetric detection at 410 nm as a measure of enzymatic activity. 4-Nitrophenyl palmitate is used to characterize the activity of various bacterial and mammalian enzymes, including those from Burkholderia and porcine pancreatic lipase .

Cat. No.	Product Name	Type

HY-W127391

1,2-Dilaurin (Rac)-1,2-Didodecanoylglycerol	Biochemical Assay Reagents
1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

1,2-Dilaurin

(Rac)-1,2-Didodecanoylglycerol

Biochemical Assay Reagents

1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126411

Peonidin-3-O-galactoside chloride	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Lipase ATP Synthase
Peonidin-3-O-galactoside chloride is an anthocyanin with antioxidant properties and blood-brain barrier permeability. Peonidin-3-O-galactoside chloride inhibits pancreatic lipase, with an IC₅₀ value of 23.2 μg/mL against porcine pancreatic lipase. Peonidin-3-O-galactoside chloride mediates neuroprotection, regulates glucose metabolism, protects cells from high glucose-induced damage, promotes glucose uptake and increases ATP production. Peonidin-3-O-galactoside (chloride) can be used in the research of obesity and neurodegenerative diseases .

HY-N8599

Cichoriin 2 Publications Verification	Infection Structural Classification Monophenols other families Classification of Application Fields Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀ = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

HY-119741

Salacinol	Structural Classification Natural Products Salacia reticulata Wight Celastraceae Plants Source Classification	Glycosidase Lipase
Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .

HY-N7163

(2S)-5,7,3',5'-Tetrahydroxyflavanone (2S)-3',5,5'7-Tetrahydroxyflavanone	Viguiera dentata (Cav.) Spreng. Structural Classification Flavonoids Labiatae Flavonones Plants Source Classification	Lipase
(2S)-5,7,3',5'-Tetrahydroxyflavanone ((2S)-3',5,5'7-Tetrahydroxyflavanone) is a porcine pancreatic lipase modulator with an IC₅₀ of >200 μM against porcine pancreatic lipase. (2S)-5,7,3',5'-Tetrahydroxyflavanone interacts with an enzyme involved in triglyceride hydrolysis .

HY-N17567

Morusalnol A	Structural Classification Monophenols Phenols Plants Moraceae Morus alba Linn. Source Classification	Lipase
Morusalnol A is a arylbenzofuran derivative found in the root bark of Morus alba. Morusalnol A is a **pancreatic lipase** inhibitor with a porcine pancreatic lipase IC₅₀ of 0.71 μM. Morusalnol A inhibits pancreatic lipase activity. Morusalnol A can be used for the research of obesity .

HY-N8362

1-Isomangostin	Natural Products Guttiferae Garcinia mangostana Linn. Plants Source Classification	Lipase
1-Isomangostin is an inhibitor of **pancreatic lipase*. 1-Isomangostin inhibits porcine* pancreatic lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N17876

Royleanonic acid	Quinones Structural Classification Labiatae Pteris semipinnata L. Sp. Plants Phenanthrenequinones Source Classification	Lipase
Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L. Royleanonic acid is a **porcine pancreatic lipase inhibitor with an IC₅₀** of 35 μg/mL .

HY-N11721

5-Hydroxyaloin A	Structural Classification Liliaceae Aloe microstigma Salm-Dyck Phenols Polyphenols Plants Source Classification	SOD Lipase
5-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at lipase’s active site and SOD’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity .

HY-N19783

Carambolaside M	Structural Classification Polysaccharides Averrhoa carambola L. Plants Oxalidaceae Saccharides Source Classification	Drug Derivative
Carambolaside M acts as an ABTS radical cation scavenger. Carambolaside M scavenges ABTS radical cations. Carambolaside M is isolated from the fresh sweet fruits of Averrhoa carambola L., a plant belonging to the genus Averrhoa in the Oxalidaceae family .

HY-W719455

Pungenin	Structural Classification Pinaceae Picea obovata Ledeb. Plants Saccharides Monosaccharides Source Classification	Lipase
Pungenin is a compound that can be isolated from Leontopodium leontopodioides. Pungenin exhibits lipase inhibitory activity. Pungenin reuduces triglyceride absorption .

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