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Art. -Nr.: HY-119741

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Salacinol

Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus.

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CAS. Nr.: 200399-47-9
Formel: C₉H₁₈O₉S₂
Molecular Weight:334.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Salacinol Chemical Structure

CAS. Nr.: 200399-47-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

α‑glucosidase

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	0.5 μM Compound: 12, Salacinol	Inhibition of maltase in human Caco-2 cell membrane Inhibition of maltase in human Caco-2 cell membrane	[PMID: 18258441]

In Vitro

Salacinol (300 mg/L; 30 min) significantly inhibits porcine pancreatic lipase activity by 12.6%^[1].
Salacinol (100 mg/L; 2 h) significantly inhibits rat adipose tissue-derived lipoprotein lipase activity by 13.6%^[1].
Salacinol (100 mg/L; 18 h) reduces remaining triglyceride content in rat epididymal fat-derived adipocytes to 75.3% of vehicle control^[1].
Salacinol (30 min) competitively inhibits rat small intestinal brush border membrane vesicle maltase, sucrase, and isomaltase with IC₅₀ values of 3.2, 0.84, and 0.59 μg/mL, respectively, and K_i values of 0.31, 0.32, and 0.47 μg/mL, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Salacinol (1.3-10 mg/kg; p.o.) potently inhibits sucrose-induced serum glucose elevation in fasted male Wistar rats, with significant activity observed at oral doses as low as 1.3 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sucrose-induced sucrose-induced Wistar (male, weight 130-170 g)^[2]
Dosage:

1.3 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration:

p.o.
Result:

Significantly inhibited the increase in serum glucose.

Chemical Information

CAS. Nr. 200399-47-9
Molecular Weight 334.36
Formel C₉H₁₈O₉S₂
SMILES

OC[C@@H]([C@@H](C[S@+]1[C@@H]([C@H]([C@@H](C1)O)O)CO)O)OS(=O)([O-])=O
Structure Classification
- Others
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Signal Pathway Related

Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yoshikawa M, et al. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J Nutr. 2002;132(7):1819-1824. [Content Brief]

[2]. Yoshikawa M, et al. Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the Ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India[J]. Tetrahedron Letters, 1997, 38(48): 8367-8370.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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