Peonidin-3-O-galactoside chloride

Name: Peonidin-3-O-galactoside chloride
Brand: MedChemExpress
SKU: HY-126411
Rating: 4.5 (1 reviews)

Cat. No.: HY-126411 Pureté: 97.07%: Fiche technique
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Peonidin-3-O-galactoside chloride is an anthocyanin with antioxidant properties and blood-brain barrier permeability. Peonidin-3-O-galactoside chloride inhibits pancreatic lipase, with an IC₅₀ value of 23.2 μg/mL against porcine pancreatic lipase. Peonidin-3-O-galactoside chloride mediates neuroprotection, regulates glucose metabolism, protects cells from high glucose-induced damage, promotes glucose uptake and increases ATP production. Peonidin-3-O-galactoside (chloride) can be used in the research of obesity and neurodegenerative diseases.

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Peonidin-3-O-galactoside chloride Chemical Structure

CAS No. : 28148-89-2

Size	Stock	Quantité
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis
100 mg	Obtenir un devis

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Based on 1 publication(s) in Google Scholar

Recommandations en vedette

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•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
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Description

In Vitro

Peonidin-3-O-galactoside (Pn3Ga) (0.1 μM–10 mM; 30 min incubation with enzyme, 1.5 h with substrate) chloride potently inhibits porcine pancreatic lipase with an IC₅₀ of 23.2 μg/mL (50.1 μM) and binds to it at 310 K via static quenching^1].
Peonidin-3-O-galactoside chloride is the predominant anthocyanin in mature red cranberries^[2].
Peonidin-3-O-galactoside (5-100 μM; 24, 48 h for baseline assays; 20, 50 μM; 36 h for high-glucose assays) chloride protects HT22 cells from high-glucose-induced injury by increasing cell viability, glucose consumption, and ATP production^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Peonidin-3-O-galactoside (300 mg/kg; p.o.; single dose) chloride, a metabolite of Cyanidin 3-O-β-galactoside, crosses the blood-brain barrier in male Sprague-Dawley rats, supporting potential neuroprotective activity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley (male, 6-week-old, 200 g)^[4]
Dosage:	300 mg/kg
Administration:	p.o.; single dose
Result:	Was detected in rat brain tissue with a peak area of 73 × 10³, confirming it crosses the blood-brain barrier.

Masse moléculaire

498.86

Formule

C₂₂H₂₃ClO₁₁

CAS No.

28148-89-2

Appearance

Solid

Color

Brown to black

SMILES

COC1=CC(C2=C(O[C@H]3[C@@H]([C@H]([C@H]([C@@H](CO)O3)O)O)O)C=C4C(C=C(O)C=C4O)=[O+]2)=CC=C1O.[Cl-]

Structure Classification

Initial Source

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (100.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 0.5 mg/mL (1.00 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0046 mL	10.0229 mL	20.0457 mL
5 mM	0.4009 mL	2.0046 mL	4.0091 mL
10 mM	0.2005 mL	1.0023 mL	2.0046 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (2.51 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (2.51 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 1.25 mg/mL (2.51 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 97.07%

Select Batch:

Fiche technique (281 KB) SDS (252 KB)

COA (256 KB) HNMR (285 KB) RP-HPLC (258 KB) MS (68 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Xie L, et al. Discovery of anthocyanins from cranberry extract as pancreatic lipase inhibitors using a combined approach of ultrafiltration, molecular simulation and spectroscopy. Food & Function, 2020, 11(10): 8606-8618.

[2]. Tulio AZ, et al. Phenolic composition, antioxidant properties, and endothelial cell function of red and white cranberry fruits[J]. Food Chemistry, 2014, 164: 158-166.

[3]. Liaudanskas M, et al. Determination of Biologically Active Compounds and Antioxidant Capacity In Vitro in Fruit of Small Cranberries (Vaccinium oxycoccos L.) Growing in Natural Habitats in Lithuania. Antioxidants (Basel). 2024 Aug 28;13(9):1045.

[4]. Liu X, et al. Pharmacokinetics, Tissue Distribution, and Metabolic Profile of Cyanidin 3-O-β-Galactoside Purified From Black Chokeberry. Mol Nutr Food Res. 2025;69(21):e70219.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	5 mM	0.4009 mL	2.0046 mL	4.0091 mL	10.0229 mL
	10 mM	0.2005 mL	1.0023 mL	2.0046 mL	5.0114 mL
	15 mM	0.1336 mL	0.6682 mL	1.3364 mL	3.3410 mL
	20 mM	0.1002 mL	0.5011 mL	1.0023 mL	2.5057 mL
	25 mM	0.0802 mL	0.4009 mL	0.8018 mL	2.0046 mL
	30 mM	0.0668 mL	0.3341 mL	0.6682 mL	1.6705 mL
	40 mM	0.0501 mL	0.2506 mL	0.5011 mL	1.2529 mL
	50 mM	0.0401 mL	0.2005 mL	0.4009 mL	1.0023 mL
	60 mM	0.0334 mL	0.1670 mL	0.3341 mL	0.8352 mL
	80 mM	0.0251 mL	0.1253 mL	0.2506 mL	0.6264 mL
	100 mM	0.0200 mL	0.1002 mL	0.2005 mL	0.5011 mL