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Results for "

spondin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Organoid (1) Wnt (1)
By Research Areas:	Cancer (2) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112484

RS-246204 2 Publications Verification	Organoid	Cancer
RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein.

HY-P99401

Rosmantuzumab OMP-131R10	Wnt	Cancer
Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors .

Cat. No.	Product Name	Target	Research Area

HY-P10500

NX210	Peptides	Neurological Disease
NX210 is a dodecapeptide derived from the SCO-spondin protein. NX210 can increase cell survival and induce neurite outgrowth, and participate in cell-cell and cell-matrix interactions. NX210 can be used in research on spinal cord injury recovery .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99401

Rosmantuzumab OMP-131R10	Wnt	Cancer
Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors .

Species:	Human (13) Mouse (4)
Tag:	SUMO (1) His (11) Avi (1) Fc (5)
Source:	HEK293 (13) CHO (1) CHO (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76582

	*RSPO2/R-Spondin* 2 Protein, Human (HEK293, Fc)** R-spondin-2; Roof plate-specific spondin-2; RSPO2	Human	HEK293
	RSPO2 is a key activator of the canonical Wnt pathway, serving as a ligand for LGR4-6 receptors and forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and increases target gene expression. RSPO2/R-Spondin 2 Protein, Human (HEK293, Fc) is the recombinant human-derived RSPO2/R-Spondin 2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705671

	*RSPO1/R-spondin-1 Protein, Human (CHO)* R-spondin-1; Roof plate-specific spondin-1; RSPO1	Human	CHO
	RSPO1/R-spondin-1 is a secreted glycoprotein. RSPO1/R-spondin-1 binds to LGR4/5/6 receptors and ZNRF3/E3 ubiquitin ligases, inhibits Wnt receptor degradation, stabilizes β-catenin and promotes its nuclear translocation, and activates target gene transcription. RSPO1/R-spondin-1 promotes intestinal organoid survival, induces pancreatic β-cell proliferation to improve diabetes, enhances osteogenic differentiation of mesenchymal stem cells to treat osteoporosis, and inhibits bone erosion in arthritis models. RSPO1/R-spondin-1 Protein, Human (CHO) is a recombinant RSPO1/R-spondin-1 protein expressed by HEK293.

HY-P7114

	*RSPO1/R-spondin-1 Protein, Human (CHO, His)* Maximum Cited Publications 16 Publications Verification rHuR-spondin-1/RSPO1; Roof plate-specific spondin-1	Human	CHO
	RSPO1/R-spondin-1 is a potent activator of the Wnt/β-catenin signaling pathway and a secretory glycoprotein belonging to the R-spondin family. RSPO1 homotetramers synergize with LRP5/6 via LGR4/5/6 and activate the Wnt/β-catenin pathway by inhibiting DKK1/Kremen-mediated LRP6 endocytosis. RSPO1 promotes β-catenin nuclear translocation, drives HSC activation in liver fibrosis, inhibits adipocyte thermogenic gene expression, and promotes intestinal epithelial proliferation. RSPO1/R-spondin-1 Protein, Human (CHO, His) is a recombinant human RSPO1 protein expressed in CHO cells with a C-6*His tag.

HY-P76012

	*RSPO1/R-spondin-1 Protein, Mouse (CHO, His)* 3 Publications Verification R-spondin-1; Roof plate-specific spondin-1; RSPO1	Mouse	CHO
	RSPO1 activates the canonical Wnt signaling pathway by binding to the LGR4-6 receptor, triggering an increase in target gene expression. It inhibits ZNRF3, regulates the Wnt signaling pathway, and negatively regulates the TGF-β pathway. RSPO1/R-spondin-1 Protein, Mouse (CHO, His) is the recombinant mouse-derived RSPO1/R-spondin-1 protein, expressed by CHO , with C-His labeled tag.

HY-P72784

	*RSPO1/R-spondin-1 Protein, Human (HEK293, His)* 1 Publications Verification R-spondin-1; Roof plate-specific spondin-1; RSPO1	Human	HEK293
	RSPO1/R-spondin-1 is a secreted glycoprotein. RSPO1/R-spondin-1 binds to LGR4/5/6 receptors and ZNRF3/E3 ubiquitin ligases, inhibits Wnt receptor degradation, stabilizes β-catenin and promotes its nuclear translocation, and activates target gene transcription. RSPO1/R-spondin-1, Human promotes intestinal organoid survival, induces pancreatic β-cell proliferation to improve diabetes, enhances osteogenic differentiation of mesenchymal stem cells to treat osteoporosis, and inhibits bone erosion in arthritis models. RSPO1/R-spondin-1 Protein, Human (HEK293, His) is a recombinant RSPO1/R-spondin-1 protein expressed by HEK293 with a C-His tag.

HY-P76013

	*RSPO2/R-spondin-2 Protein, Mouse (HEK293, Fc)* R-spondin-2; Cristin-2; Roof plate-specific spondin-2	Mouse	HEK293
	RSPO2 is a key activator of the canonical Wnt pathway and acts as a ligand for LGR4-6 receptors (LGR4, LGR5, or LGR6). Upon binding, this complex forms with phosphorylated LRP6 and Frizzled receptors, activating the canonical Wnt pathway and upregulating target genes. RSPO2/R-spondin-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived RSPO2/R-spondin-2 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P700443

	*RSPO1/R-spondin-1 Protein, Human (HEK293, His-Avi)* rHuR-spondin-1/RSPO1; Roof plate-specific spondin-1	Human	HEK293
	RSPO1 or R-spondin-1 activates the canonical Wnt pathway through ligand binding to the LGR4-6 receptor, forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction upregulates target gene expression. RSPO1/R-spondin-1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived RSPO1/R-spondin-1 protein, expressed by HEK293 , with C-Avi, C-10*His labeled tag.

HY-P72784A

	*RSPO1/R-spondin-1 Protein, Human (125a.a, HEK293, His)* 1 Publications Verification R-spondin-1; Roof plate-specific spondin-1; RSPO1	Human	HEK293
	RSPO1 or R-spondin-1 activates the canonical Wnt pathway through ligand binding to the LGR4-6 receptor, forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction upregulates target gene expression. RSPO1/R-spondin-1 Protein, Human (125a.a, HEK293, His) is the recombinant human-derived RSPO1/R-spondin-1 protein, expressed by HEK293 , with C-8*His labeled tag.

HY-P704403

	*RSPO1/R-spondin-1 Protein, Human (125a.a, HEK293, hFc)* R-spondin-1; Roof plate-specific spondin-1; RSPO1	Human	HEK293
	RSPO1 or R-spondin-1 activates the canonical Wnt pathway through ligand binding to the LGR4-6 receptor, forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction upregulates target gene expression. RSPO1/R-spondin-1 Protein, Human (125a.a, HEK293, hFc) is the recombinant human-derived RSPO1/R-spondin-1 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P700253AF

	*Animal-Free RSPO1/R-spondin-1 Protein, Human (243a.a, HEK293, His, SUMO)* R-spondin-1; Roof plate-specific spondin-1; RSPO1	Human	HEK293
	RSPO1 or R-spondin-1 activates the canonical Wnt pathway through ligand binding to the LGR4-6 receptor, forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction upregulates target gene expression. Animal-Free RSPO1/R-spondin-1 Protein, Human (243a.a, HEK293, His, SUMO) is the recombinant human-derived animal-FreeRSPO1/R-spondin-1 protein, expressed by HEK293 , with N-His, N-SUMO labeled tag. This product is for cell culture use only.

HY-P70557

	*RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His)* R-spondin-3; RSPO3; Protein with TSP type-1 repeat; Roof plate-specific spondin-3; Thrombospondin type-1 domain-containing protein 2; PWTSR; THSD2; CRISTIN1	Human	HEK293
	RSPO3 is a potent activator of the canonical Wnt pathway and can bind to LGR4-6 receptors to initiate a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and upregulates target genes. RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) is the recombinant human-derived RSPO3/R-spondin-3 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.

HY-P78344

	*RSPO1/R-spondin-1 Protein, Mouse (HEK293, His)* R-spondin-1; RSPO1; CRISTIN3; FLJ40906; RP11-566C13.1; RSPO	Mouse	HEK293
	RSPO1 activates the canonical Wnt signaling pathway by binding to the LGR4-6 receptor, triggering an increase in target gene expression. It inhibits ZNRF3, regulates the Wnt signaling pathway, and negatively regulates the TGF-β pathway. RSPO1/R-spondin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived RSPO1/R-spondin-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700262

	*RSPO3/R-spondin-3 Protein, Human (HEK293, His)* R-spondin-3; RSPO3; Protein with TSP type-1 repeat; PWTSR; THSD2; CRISTIN1	Human	HEK293
	RSPO3 is a potent activator of the canonical Wnt pathway and can bind to LGR4-6 receptors to initiate a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and upregulates target genes. R-spondin 3 Protein, Human (HEK293, His) is the recombinant human-derived R-spondin 3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704873

	*RSPO3/R-spondin-3 Protein, Human (HEK293, Fc)* R-spondin-3; RSPO3; Protein with TSP type-1 repeat; PWTSR; THSD2; CRISTIN1	Human	HEK293
	RSPO3 is a potent activator of the canonical Wnt pathway and can bind to LGR4-6 receptors to initiate a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and upregulates target genes. RSPO3/R-spondin-3 Protein, Human (HEK293, Fc) is the recombinant human-derived R-spondin 3 protein, expressed by HEK293 , with C-Fc labeled tag.

HY-P700255

	*RSPO1/R-spondin-1 Protein, Mouse (189a.a, His)* 1 Publications Verification	Mouse	E. coli
	RSPO1 activates the canonical Wnt signaling pathway by binding to the LGR4-6 receptor, triggering an increase in target gene expression. It inhibits ZNRF3, regulates the Wnt signaling pathway, and negatively regulates the TGF-β pathway. RSPO1/R-spondin-1 Protein, Mouse (189a.a, His) is the recombinant mouse-derived RSPO1/R-spondin-1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70142

	Spondin-2/SPON2 Protein, Human (HEK293, His) 1 Publications Verification rHuspondin-2/SPON2, His; spondin-2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL-1; Mindin; SPON2	Human	HEK293
	Spondin-2 protein is a matricellular protein with antigen binding, lipopolysaccharide binding and metal ion binding activity. Spondin-2 is essential for recruiting lymphocytes and initiating immune responses while being involved in cell adhesion, defense response to other organism; opsonization; and positive regulation of cytokine production. Spondin-2 is found to promote infiltration of M1-like macrophages and inhibits tumor metastasis in cancer research. Spondin-2/SPON2 Protein, Human (HEK293, His) is the recombinant human-derived Spondin-2/SPON2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70142A

	Spondin-2/SPON2 Protein, Human (Q9BUD6, HEK293, His) rHuspondin-2/SPON2, His; spondin-2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL-1; Mindin; SPON2	Human	HEK293
	Spondin-2/SPON2 protein, as a cell adhesion molecule, plays a key role in promoting the adhesion and growth of hippocampal embryonic neurons.In addition to its role in neurodevelopment, SPON2 acts as a direct binder of bacteria and their components, functioning as an opsonin to promote phagocytosis of bacteria by macrophages.Spondin-2/SPON2 Protein, Human (Q9BUD6, HEK293, His) is the recombinant human-derived Spondin-2/SPON2 protein, expressed by HEK293 , with His labeled tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	WB (4) ELISA (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85357

	*R-Spondin* Antibody (YA5049)** RSPO1; R-spondin-1; Roof plate-specific spondin-1; hRspo1	WB, ELISA	Human
	R-Spondin Antibody (YA5049) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to R-Spondin.

HY-P85357A

	*R-Spondin* Antibody (YA5049)(PBS only)** RSPO1; R-spondin-1; Roof plate-specific spondin-1; hRspo1	WB, ELISA	Human
	R-Spondin Antibody (YA5049) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to R-Spondin.

HY-P82304

	SPON2 Antibody (YA2049) DIL1; DIL-1; MINDIN; M-spondin	WB	Human, Mouse, Rat
	SPON2 Antibody (YA2049) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPON2.

HY-P82304A

	SPON2 Antibody (YA2049)(PBS only) DIL1; DIL-1; MINDIN; M-spondin	WB	Human, Mouse, Rat
	SPON2 Antibody (YA2049) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPON2.

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