2. Inhibitory Antibodies
  3. Rosmantuzumab

Rosmantuzumab  (Synonyms: OMP-131R10)

Cat. No.: HY-P99401 Purity: 95.00%
COA

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Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors.

For research use only. We do not sell to patients.

Rosmantuzumab Chemical Structure

Rosmantuzumab Chemical Structure

CAS No. : 1684393-04-1

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5 mg USD 910 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors[1].

In Vivo

Rosmantuzumab (25 mg/kg; i.p., once a week for 4 weeks) significantly protects the animals from developing liver fibrosis[1].
Rosmantuzumab (25 mg/kg; i.p., once for two weeks, for total 6 weeks) significantly inhibits skin thickness, collagen deposition, and number of α-SMA positive cells in bleomycin-induced lung fibrosis mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57B1/6J CCl4 liver fibrosis mouse models[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection; 25 mg/kg, once a week for 4 weeks
Result: Significantly decreased collagen I and collagen III mRNAs, and inhibits β-catenin cytoplasmic and nuclear translocation.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Rosmantuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosmantuzumab1684393-04-1OMP-131R10OthersmAbfibrosisbleomycinmousecancerInhibitorinhibitorinhibit

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