RSPO3 - R-spondin 3 Gene

Also Known as PWTSR; THSD2; CRISTIN1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84870

About RSPO3

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,118,671-127,199,481 (from NCBI)

This gene has 3 transcripts (splice variants), 242 orthologues, 3 paralogues and is associated with 61 phenotypes. Broad expression in endometrium (RPKM 18.7), placenta (RPKM 8.3) and 14 other tissues.

Summary

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

RSPO3 Products (1)

mRNA Protein Name
NM_032784.5 NP_116173.2 R-spondin-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
22615920 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
29769720 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RSPO3 Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (151 - 202)

  • 0
  • 100
  • 200
  • 272 a.a.
Protein Preferred Names Protein Names

R-spondin-3

  • R-spondin 3 homolog

Recombinant RSPO3 Proteins

Cat. No. Product Name Accession Purity
HY-P70557 RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) Q9BXY4-1 (Q22-V201) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700262 RSPO3/R-spondin-3 Protein, Human (HEK293, His) Q9BXY4-1 (Q22-V146) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Tetraamelia Syndrome

  • Tetra-Amelia Syndrome

  • Tetraamelia-Multiple Malformations Syndrome

  • Tetra-Amelia

  • Tetra-Amelia, Autosomal Recessive

  • Tetraamelia, Autosomal Recessive

  • Total Amelia

  • Zimmer Phocomelia

  • Tetams

  • Zimmer Taub Sova Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99401 Rosmantuzumab Inhibitor 99.29% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12307 RSPO3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17424 Rspo3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23879 Rspo3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RSPO3 RGD RGD:1563246
Felis catus RSPO3 VGNC VGNC:64798
Bos taurus RSPO3 VGNC VGNC:106906
Mus musculus RSPO3 MGD MGI:1920030
Canis familiaris RSPO3 VGNC VGNC:49764
Macaca mulatta RSPO3 VGNC VGNC:77066
Others RSPO3 NCBI