2. Gene
  3. RSPO3 - R-spondin 3 Gene

RSPO3 - R-spondin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PWTSR; THSD2; CRISTIN1

Gene ID: 84870 | Gene type: protein coding

About RSPO3

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,118,671-127,199,481 (from NCBI)

This gene has 3 transcripts (splice variants), 242 orthologues, 3 paralogues and is associated with 61 phenotypes. Broad expression in endometrium (RPKM 18.7), placenta (RPKM 8.3) and 14 other tissues.

Summary

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

RSPO3 Products(1)

mRNA Protein Name
NM_032784.5 NP_116173.2 R-spondin-3 precursor

RSPO3 Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (151 - 202)

  • 0
  • 100
  • 200
  • 272 a.a.
Protein Preferred Names Protein Names

R-spondin-3

R-spondin 3 homolog

Recombinant RSPO3 Proteins

Cat. No. Product Name Accession Purity
HY-P70557 RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) Q9BXY4 (Q22-V201) ≥95%
HY-P76014 RSPO3/R-spondin-3 Protein, Human (HEK293, His) Q9BXY4 (Q22-V146) ≥95%
HY-P700262 R-spondin 3 Protein, Human (125aa, HEK293, His) Q9BXY4-1 (Q22-V146) ≥95%
HY-P700262A R-spondin 3 Protein, Human (125aa, HEK293, C-His) Q9BXY4-1 (Q22-V146) ≥95%

Related Diseases

Diseases Alias
Tetraamelia Syndrome

Tetra-Amelia Syndrome

Tetraamelia-Multiple Malformations Syndrome

Tetra-Amelia

Tetra-Amelia, Autosomal Recessive

Tetraamelia, Autosomal Recessive

Total Amelia

Zimmer Phocomelia

Tetams

Zimmer Taub Sova Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12307 RSPO3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RSPO3 RGD RGD:1563246
Felis catus RSPO3 VGNC VGNC:64798
Bos taurus RSPO3 VGNC VGNC:106906
Mus musculus RSPO3 MGD MGI:1920030
Canis familiaris RSPO3 VGNC VGNC:49764
Macaca mulatta RSPO3 VGNC VGNC:77066
Others RSPO3 NCBI