24 Results for "

tumor promotion

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "tumor promotion" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-14617
CAS No.: 27113-22-0
Purity:  99.87%
Synonyms: [6]-Gingerone; [6]-Paradol
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
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3
3 Cited Publications
Cat. No.: HY-N0886
CAS No.: 28371-16-6
Synonyms: Isobarbaloin
Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation .
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1
1 Cited Publications
Cat. No.: HY-14617R
CAS No.: 27113-22-0
Synonyms: [6]-Gingerone (Standard); [6]-Paradol (Standard)
Paradol (Standard) is the analytical standard of Paradol. This product is intended for research and analytical applications. Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
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Cat. No.: HY-106449
CAS No.: 203191-10-0
Purity:  ≥98.0%
Synonyms: DA-6034 free acid
Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca( 2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury .
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Cat. No.: HY-N7691
CAS No.: 389122-01-4
Synonyms: Karounidiol dibenzoate
3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a multiflorane-type triterpene benzoate that inhibits Phorbol 12-myristate 13-acetate (TPA) (HY-18739)-induced Epstein-Barr virus early antigen activation and exhibits tumor-promotion inhibitory activity. 3,29-O-Dibenzoyloxykarounidiol is used in cancer-related research .
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Cat. No.: HY-W348485
CAS No.: 899937-47-4
Target:  

mTOR

Research Areas:  

Cancer

WRX606 is an orally active nonrapalog inhibitor for mTOR complex 1 (mTORC1M). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 (S6K1) (IC50 = 10 nM) and eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC50 = 0.27 μM) in MCF-7 cells. WRX606 suppresses tumor growth in mice without promotion of metastasis. WRX606 can be studied in research as an antitumor agent .
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Cat. No.: HY-N6861
CAS No.: 95311-95-8
Lucidenic acid B is a triterpenoid compound. Lucidenic acid B inhibits the activities of ERK1/2, AP-1, NF-kB, and IKK, suppresses PMA (Phorbol 12-myristate 13-acetate) (HY-18739)-induced MMP-9 expression and cell invasion, and induces apoptosis in leukemia cells via the mitochondrial pathway. Lucidenic acid B inhibits the growth of various cancer cell lines without affecting normal lymphocytes and does not induce G1 phase arrest or necrosis. Lucidenic acid B can be used in research on hepatocellular carcinoma, human acute promyelocytic leukemia, and skin tumor promotion .
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Cat. No.: HY-161248
Target:  

Microtubule/Tubulin

Research Areas:  

Cancer

E7130 is a microtubule inhibitor, which ameliorates the tumor microenvironment through suppression of cancer-associated fibroblasts (CAF) and promotion of tumor vasculature remodeling .
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Cat. No.: HY-P11417
CAS No.: 106678-69-7
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

Epidermal mitosis inhibiting pentapeptide is a five-peptide that acts as a physiological inhibitor of epidermal cell proliferation. This pentapeptide can significantly reduce the DNA synthesis rate and mitotic rate of epidermal keratinocytes. Epidermal mitosis inhibiting pentapeptide moderately enhances the occurrence of skin tumors in skin cancer models, but also shows a higher tendency to promote the regression of already formed tumors. Epidermal mitosis inhibiting pentapeptide can be hydrolyzed by angiotensin-converting enzyme (ACE). Epidermal mitosis inhibiting pentapeptide can be used in cancer process research .
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Cat. No.: HY-N10390
CAS No.: 96574-03-7
3β-Hydroxylanosta-8,24-dien-21-al is a lanostane-type triterpene. 3β-Hydroxylanosta-8,24-dien-21-al can inhibit the tumor promotion, reducing the percentage of mice bearing papillomas .
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Cat. No.: HY-108963
CAS No.: 99682-33-4
Research Areas:  

Cancer

LY 170198 is a protein kinase C inhibitor and a LTD4 antagonist. LY 170198 is promising for research of tumor promotion, oncogene activation, protein phosphorylation, feedback mechanisms in signal transduction and cellular responses to growth factors .
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Cat. No.: HY-N15758
CAS No.: 139006-28-3
Amorphispironone (Compound 1) is a rotenoid that can be isolated the leaves of A. fruticosa. Amorphispironone exhibits remarkable inhibitory effects on EBV-EA activation induced by TPA. Amorphispironone exhibits potent anti-tumor-promotion activity on mouse skin tumor promotion in vivo .
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Cat. No.: HY-N8449
CAS No.: 156398-61-7
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion .
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Cat. No.: HY-P3842
CAS No.: 149839-93-0
Target:  

PKC

Research Areas:  

Cancer

Protein Kinase C (661-671) is a fragment peptide of β1 subspecies of protein kinase C (PKC). PKC plays a role in cellular growth control and tumor promotion .
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Cat. No.: HY-N1687
CAS No.: 125305-73-9
21,24-Epoxycycloartane-3,25-diol (compound 15 or 16) is a cycloartanoid triterpene that can be isolated from the leaves of Lansium domesticum. 21,24-Epoxycycloartane-3,25-diol inhibits skin-tumor promotion .
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Cat. No.: HY-N0886R
CAS No.: 28371-16-6
Synonyms: Isobarbaloin (Standard)
Aloin B (Isobarbaloin) (Standard) is the analytical standard of Aloin B. This product is intended for research and analytical applications. Aloin B is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation .
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Cat. No.: HY-178417
CAS No.: 2732914-43-9
Research Areas:  

Cancer

Angustilongine M is a microtubule-targeting antitumor alkaloid (IC50=0.2 μM against HT-29 cells). Angustilongine M induces G0/G1 cell cycle arrest and mitochondrial apoptosis via tubulin polymerization promotion. Angustilongine M is promising for research of colorectal cancer and other solid tumors .
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Cat. No.: HY-N21575
CAS No.: 49620-09-9
Milliamine C is a diterpenoid ester of the euphane type that inhibits the specific binding of phorbol-12,13-dipropionate to mouse epidermal particulate fractions and induces skin irritation, but exhibits very weak or undetectable tumor-promoting activity. Milliamine C can be used in studies related to skin tumor promotion .
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Cat. No.: HY-N19810
CAS No.: 15591-75-0
Synonyms: Libanotine; Cnidimine
Edultin (Libanotine; Cnidimine) is an angular furanocoumarin. Edultin potently inhibits TPA (HY-18739)-induced early signals associated with tumor promotion (phospholipid metabolism). Edultin exerts mild inhibitory effects on some clinically isolated strains of Pseudomonas aeruginosa and Staphylococcus aureus. Edultin can be used in studies related to tumor promotion and bacterial infections .
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Cat. No.: HY-183561
CAS No.: 150956-50-6
Target:  

TNF Receptor HIV

Research Areas:  

Infection Cancer

Canventol is an antitumor agent that inhibits the release of TNF-α. Canventol inhibits protein isoprenylation, regulates mevalonate metabolism, enhances Okadaic acid (HY-N6785)-induced early response gene expression, suppresses cell transformation, and inhibits HIV-1 production in infected cells. Canventol can be used in studies related to skin tumor promotion and cancer .
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