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Cat. No.: HY-N15758

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Amorphispironone

Amorphispironone (Compound 1) is a rotenoid that can be isolated the leaves of A. fruticosa. Amorphispironone exhibits remarkable inhibitory effects on EBV-EA activation induced by TPA. Amorphispironone exhibits potent anti-tumor-promotion activity on mouse skin tumor promotion in vivo.

For research use only. We do not sell to patients.

CAS No.: 139006-28-3
Formula: C₂₃H₂₂O₇
Molecular Weight:410.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Amorphispironone Chemical Structure

CAS No.: 139006-28-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	7.39 μM Compound: 4	Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay	[PMID: 18841906]
KB	ED₅₀	0.58 μg/mL Compound: 4	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8326318]
RAW264.7	IC₅₀	13.9 μM Compound: 4	Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay	[PMID: 18841906]
RPMI-7951	ED₅₀	0.61 μg/mL Compound: 4	Cytotoxicity against human RPMI7951 cells Cytotoxicity against human RPMI7951 cells	[PMID: 8326318]

Chemical Information

CAS No. 139006-28-3
Molecular Weight 410.42
Formula C₂₃H₂₂O₇
SMILES

CC(O1)(C)C=CC2=C1C=CC3=C2O[C@@]4([H])[C@@]([C@@](C5=O)(C=C(OC)C(OC)=C5)OC4)([H])C3=O
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Konoshima, T., et al., (1993). Studies on inhibitors of skin tumor promotion, XII. Rotenoids from Amorpha fruticosa. Journal of natural products, 56(6), 843–848. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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