Epidermal mitosis inhibiting pentapeptide 

Epidermal mitosis inhibiting pentapeptide is a five-peptide that acts as a physiological inhibitor of epidermal cell proliferation. This pentapeptide can significantly reduce the DNA synthesis rate and mitotic rate of epidermal keratinocytes. Epidermal mitosis inhibiting pentapeptide moderately enhances the occurrence of skin tumors in skin cancer models, but also shows a higher tendency to promote the regression of already formed tumors. Epidermal mitosis inhibiting pentapeptide can be hydrolyzed by angiotensin-converting enzyme (ACE). Epidermal mitosis inhibiting pentapeptide can be used in cancer process research^[1][2].

517.44

C₁₉H₂₇N₅O₁₂

106678-69-7

{pGlu}-Glu-Asp-Ser-Gly

{pGlu}-EDSG

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bramucci M, et al. Presence and comparison of angiotensin converting enzyme in commercial cell culture sera. Biochem Mol Biol Int. 1999 Jan;47(1):107-15.  [Content Brief]

  [2]. Iversen OH,et al. Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide. Carcinogenesis. 1993 Dec;14(12):2537-42.  [Content Brief]