Epidermal mitosis inhibiting pentapeptide
Epidermal mitosis inhibiting pentapeptide is a five-peptide that acts as a physiological inhibitor of epidermal cell proliferation. This pentapeptide can significantly reduce the DNA synthesis rate and mitotic rate of epidermal keratinocytes. Epidermal mitosis inhibiting pentapeptide moderately enhances the occurrence of skin tumors in skin cancer models, but also shows a higher tendency to promote the regression of already formed tumors. Epidermal mitosis inhibiting pentapeptide can be hydrolyzed by angiotensin-converting enzyme (ACE). Epidermal mitosis inhibiting pentapeptide can be used in cancer process research.
For research use only. We do not sell to patients.
- CAS No.: 106678-69-7
- Formula: C19H27N5O12
- Molecular Weight:517.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 106678-69-7
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Molecular Weight 517.44
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Formula C19H27N5O12
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Sequence
{pGlu}-Glu-Asp-Ser-Gly
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Sequence Shortening
{pGlu}-EDSG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Bramucci M, et al. Presence and comparison of angiotensin converting enzyme in commercial cell culture sera. Biochem Mol Biol Int. 1999 Jan;47(1):107-15. [Content Brief]
[2]. Iversen OH,et al. Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide. Carcinogenesis. 1993 Dec;14(12):2537-42. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Epidermal mitosis inhibiting pentapeptide Related Classifications
HY-P11417 Related Classifications
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