2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite P2Y Receptor
  4. Uridine triphosphate trisodium salt

Uridine triphosphate trisodium salt  (Synonyms: UTP trisodium salt; Uridine 5'-triphosphate trisodium salt)

Cat. No.: HY-W013093 Pureza: 96.0%
COA
SDS
Instrucciones de manejo Technical Support

Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors.

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Uridine triphosphate trisodium salt

Uridine triphosphate trisodium salt Estructura química

No. CAS : 19817-92-6

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in Water En stock
Solid
50 mg En stock
100 mg En stock
500 mg En stock
1 g En stock
5 g En stock
10 g   Obtener un presupuesto  
50 g   Obtener un presupuesto  

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Based on 4 publication(s) in Google Scholar

Other Forms of Uridine triphosphate trisodium salt:

Uridine triphosphate trisodium salt Related Antibodies

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  • Actividad biológica

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  • Referencias

  • Revisión del cliente

Descripciòn

Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Uridine triphosphate (UTP) (0, 10, 100, 250, 500, and 1000 µM; 2, 4, 6, 8, 10, and 12 h) trisodium salt enhances RT4-D6P2T cells migration and wound repair. Uridine triphosphate trisodium salt induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular MMP-2 activation and expression[2].
Uridine triphosphate (UTP) trisodium salt evokes MAPK phosphorylation in a biphasic pattern MAPK phosphorylation, with an early transient phosphorylation 5 min after treatment, and a late and sustained phosphorylation that appeared at 6 h and lasted up to 24 h[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uridine triphosphate trisodium salt Related Antibodies

Western Blot Analysis[2]

Cell Line: RT4-D6P2T cells
Concentration: 250 µM
Incubation Time: 5 min, 45 min, 2 h, 6 h, 12 h, 24 h, 48 h
Result: Induces biphasic MAPK phosphorylation.
In Vivo

Uridine triphosphate (UTP) (0.44-4.4 µg/kg; i.v.; once) trisodium salt reduces infarct size and improves rat heart function after myocardial infarct[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250-300 g; 2-3 months) with myocardial infarction (MI)[3]
Dosage: 0.44 µg/kg 30 min before MI, and 4.4 µg/kg i.v. 24 h prior to MI.
Administration: i.v.; once
Result: Reduced infarct size and improves rat heart function after myocardial infarct.
Peso molecular

550.09

Fòrmula

C9H12N2Na3O15P3
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(OP(OP([O-])([O-])=O)([O-])=O)(O)=O.[3Na+]
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 75 mg/mL (136.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8179 mL 9.0894 mL 18.1788 mL
5 mM 0.3636 mL 1.8179 mL 3.6358 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (181.79 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 97.3%

SDS (393 KB)

COA (254 KB) HNMR (113 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8179 mL 9.0894 mL 18.1788 mL 45.4471 mL
5 mM 0.3636 mL 1.8179 mL 3.6358 mL 9.0894 mL
10 mM 0.1818 mL 0.9089 mL 1.8179 mL 4.5447 mL
15 mM 0.1212 mL 0.6060 mL 1.2119 mL 3.0298 mL
20 mM 0.0909 mL 0.4545 mL 0.9089 mL 2.2724 mL
25 mM 0.0727 mL 0.3636 mL 0.7272 mL 1.8179 mL
30 mM 0.0606 mL 0.3030 mL 0.6060 mL 1.5149 mL
40 mM 0.0454 mL 0.2272 mL 0.4545 mL 1.1362 mL
50 mM 0.0364 mL 0.1818 mL 0.3636 mL 0.9089 mL
60 mM 0.0303 mL 0.1515 mL 0.3030 mL 0.7575 mL
80 mM 0.0227 mL 0.1136 mL 0.2272 mL 0.5681 mL
100 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4545 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Uridine triphosphate trisodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine triphosphate trisodium19817-92-6UTP trisodium Uridine 5'-triphosphate trisodiumEndogenous MetaboliteP2Y ReceptorInhibitorinhibitorinhibit

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