Vidarabine monohydrate

Name: Vidarabine monohydrate
Brand: MedChemExpress
SKU: HY-N6666
Rating: 5.0 (7 reviews)

Cat. No.: HY-N6666 Pureza: 99.99%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus.

Para uso exclusivo en investigación. No vendemos a pacientes.

Vidarabine monohydrate Estructura química

No. CAS : 24356-66-9

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 7 publication(s) in Google Scholar

Other Forms of Vidarabine monohydrate:

Vidarabine In-stock
Vidarabine monohydrate (Standard) Obtener un presupuesto

7 Publications Citing Use of MCE Vidarabine monohydrate

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas DNA/RNA Synthesis:

Ver todas las isoformas

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Ver todos los productos específicos de isoformas HSV:

Ver todas las isoformas

HSV-1 HSV-2 HSV

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

In Vitro

Vidarabine monohydrate inhibits herpes simplex virus, varicella-zoster virus, and cytomegalovirus in in vitro cell culture systems^[1].
Vidarabine monohydrate exerts its antiviral effect via phosphorylation to a triphosphate derivative that competitively inhibits DNA polymerase and is incorporated into terminal positions of growing DNA molecules^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vidarabine (3%; topical to the eye; four times daily) monohydrate supports normal corneal epithelial wound healing in rabbits, with epithelial quality significantly superior to Idoxuridine (HY-B0307) and comparable to placebo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	unspecified strain^[1]
Dosage:	3%
Administration:	topical to the eye; four times daily
Result:	Achieved complete healing of 5 mm corneal lesions by 60 hours, with no significant difference in healing rate compared to placebo or idoxuridine. Achieved complete healing of 10 mm corneal lesions by 8 days, with no significant difference in healing rate compared to placebo or idoxuridine. Showed significantly better regenerated epithelium quality (lower scores) than idoxuridine-treated eyes on days 4 and 7 (p = 0.05), with results comparable to placebo. Demonstrated less severe histological abnormalities compared to idoxuridine-treated eyes.

Peso molecular

285.26

Fòrmula

C₁₀H₁₅N₅O₅

No. CAS

24356-66-9

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1CO.O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 250 mg/mL (876.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5056 mL	17.5279 mL	35.0557 mL
5 mM	0.7011 mL	3.5056 mL	7.0111 mL
10 mM	0.3506 mL	1.7528 mL	3.5056 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 99.99%

Select Batch:

Ficha de datos (281 KB) SDS (479 KB)

COA (257 KB) HNMR (200 KB) RP-HPLC (309 KB) MS (68 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Whitley R, et al. Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs. 1980 Oct;20(4):267-82. [Content Brief]

[2]. VanLandingham KE, et al. Relapse of herpes simplex encephalitis after conventional acyclovir therapy. JAMA. 1988;259(7):1051-1053.

[3]. Stolk LM, et al. Formulation of a stable vidarabine infusion fluid. Pharm Weekbl Sci. 1983;5(2):57-60.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5056 mL	17.5279 mL	35.0557 mL	87.6393 mL
	5 mM	0.7011 mL	3.5056 mL	7.0111 mL	17.5279 mL
	10 mM	0.3506 mL	1.7528 mL	3.5056 mL	8.7639 mL
	15 mM	0.2337 mL	1.1685 mL	2.3370 mL	5.8426 mL
	20 mM	0.1753 mL	0.8764 mL	1.7528 mL	4.3820 mL
	25 mM	0.1402 mL	0.7011 mL	1.4022 mL	3.5056 mL
	30 mM	0.1169 mL	0.5843 mL	1.1685 mL	2.9213 mL
	40 mM	0.0876 mL	0.4382 mL	0.8764 mL	2.1910 mL
	50 mM	0.0701 mL	0.3506 mL	0.7011 mL	1.7528 mL
	60 mM	0.0584 mL	0.2921 mL	0.5843 mL	1.4607 mL
	80 mM	0.0438 mL	0.2191 mL	0.4382 mL	1.0955 mL
	100 mM	0.0351 mL	0.1753 mL	0.3506 mL	0.8764 mL