Z-VDVAD-FMK (Synonyms: Z-VD(OMe)VAD(OMe)-FMK)

Name: Z-VDVAD-FMK
Brand: MedChemExpress
SKU: HY-P1008
Rating: 5.0 (5 reviews)

Cat. No.: HY-P1008 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Z-VDVAD-FMK 화학구조

CAS No. : 210344-92-6

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 5 publication(s) in Google Scholar

Other Forms of Z-VDVAD-FMK:

Z-VDVA-(DL-Asp)-FMK 견적 받기

5 Publications Citing Use of MCE Z-VDVAD-FMK

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Caspase Isoform Specific Products:

View All Isoforms

Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis^[1]^[2]^[3].

IC₅₀ & Target^[1]

Caspase-2

In Vitro

Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death^[1].
Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells^[2].
Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152)
Concentration:	100 μM
Incubation Time:	22 hours
Result:	Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.

분자량

695.73

화학식

C₃₂H₄₆FN₅O₁₁

CAS No.

210344-92-6

Appearance

Solid

Color

White to off-white

Sequence Shortening

{Cbz}-V{Asp(OMe)}-VA-{Asp(OMe)}-CH2F

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 250 mg/mL (359.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4373 mL	7.1867 mL	14.3734 mL
5 mM	0.2875 mL	1.4373 mL	2.8747 mL
10 mM	0.1437 mL	0.7187 mL	1.4373 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (246 KB) HNMR (286 KB) MS (71 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)

References

[1]. S Gamen, et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res. 2000 Jul 10;258(1):223-35. [Content Brief]

[2]. Cédric Sapet, et al. Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood. 2006 Sep 15;108(6):1868-76. [Content Brief]

[3]. Simon W Rabkin, et al. Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors. Toxicol Appl Pharmacol. 2003 Dec 15;193(3):346-55. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4373 mL	7.1867 mL	14.3734 mL	35.9335 mL
	5 mM	0.2875 mL	1.4373 mL	2.8747 mL	7.1867 mL
	10 mM	0.1437 mL	0.7187 mL	1.4373 mL	3.5933 mL
	15 mM	0.0958 mL	0.4791 mL	0.9582 mL	2.3956 mL
	20 mM	0.0719 mL	0.3593 mL	0.7187 mL	1.7967 mL
	25 mM	0.0575 mL	0.2875 mL	0.5749 mL	1.4373 mL
	30 mM	0.0479 mL	0.2396 mL	0.4791 mL	1.1978 mL
	40 mM	0.0359 mL	0.1797 mL	0.3593 mL	0.8983 mL
	50 mM	0.0287 mL	0.1437 mL	0.2875 mL	0.7187 mL
	60 mM	0.0240 mL	0.1198 mL	0.2396 mL	0.5989 mL
	80 mM	0.0180 mL	0.0898 mL	0.1797 mL	0.4492 mL
	100 mM	0.0144 mL	0.0719 mL	0.1437 mL	0.3593 mL

Z-VDVAD-FMK Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-VDVAD-FMK210344-92-6Z-VD(OMe)VAD(OMe)-FMKCaspaseApoptosisOncosisLovastatinMevalonateCaspase-2Caspase-3HeartCardiomyocyteInhibitorinhibitorinhibit

최근 본 상품:

상품명

Requested Quantity *

고객명 *

호칭

메일주소 *

전화번호 *

Department

회사명 *

City

도

Country or Region *

비고

상품명

Lot #

고객명 *

메일주소 *

전화번호

Department *

회사명 *

Country or Region *

비고

Name
이메일 *

	Sorry, but the email address you supplied was invalid.

Z-VDVAD-FMK (Synonyms: Z-VD(OMe)VAD(OMe)-FMK)

고객리뷰

Other Forms of Z-VDVAD-FMK:

Z-VDVAD-FMK Related Antibodies

5 Publications Citing Use of MCE Z-VDVAD-FMK

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Caspase Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Z-VDVAD-FMK Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Z-VDVAD-FMK Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report