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  3. MMP
  4. 3-Aminopropionitrile fumarate (2:1)

3-Aminopropionitrile fumarate (2:1)  (Synonyms: Di-β-aminopropionitrile fumarate; β-Aminopropionitrile fumarate; β-Ammoniumpropionitrile hemifumarate; 3-アミノプロピオニトリル フマル酸塩)

製品番号: HY-107829 純度: 99.96%
COA 取扱説明書 Technical Support

3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

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CAS 番号 : 2079-89-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in Water USD 33 在庫あり
Solid
100 mg $30 在庫あり
500 mg $50 在庫あり
1 g $70 在庫あり
5 g $110 在庫あり
10 g $180 在庫あり
50 g   お問い合わせ  

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カスタマーレビュー

Based on 13 publication(s) in Google Scholar

Other Forms of 3-Aminopropionitrile fumarate (2:1):

3-Aminopropionitrile fumarate (2:1) 関連抗体

Top Publications Citing Use of Products

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2025 Aug 27;14(1):111.  [Abstract]

    The BAPN (50 mg/kg; once every two days for four weeks; ip) treatment process for orthotopic xenograft mice model.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Exp Hematol Oncol. 2025 Aug 27;14(1):111.  [Abstract]

    Western blot of vimentin, E-cadherin, CDKN1A in PBS-treated xenografts and BAPN (50 mg/kg; once every two days for four weeks; ip) -treated xenografts, using GAPDH as a control.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Morphology of cerebral edema in sham, HIBD and BAPN intervention groups (100 mg/kg/ip/day) at 72 h post-surgery.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Cell viability of BAPN (500 nM)-treated OGD/R-induced HT22 cells at 0 h, 12 h and 24 h after reoxygenation.

    3-Aminopropionitrile fumarate (2:1) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Sep 7:76:103346.  [Abstract]

    Representative TEM images of mitochondrial morphology in BAPN (500 nM) -incubated HT22 cells under OGD/R-induced conditions. Green arrows indicate normally shaped mitochondria, black arrows indicate damaged mitochondria.

    MMP アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen.

    IC50 & Target

    Collagen[1].
    体内実験

    Twenty days after the induction of tendinitis, intralesional treatment with 3-Aminopropionitrile fumarate (2:1) (BAPN-F) is performed and the contralateral limbs receive saline. A biopsy is obtained and gross and histopathological analysis is performed on the 150 th day of the experiment. The collagen fibrillar alignment pattern in the healing area is better in the 3-Aminopropionitrile fumarate (2:1) group submitted to controlled exercise than in the other group, as observed by sonographic and histopathologic examination. The present results indicate that 3-Aminopropionitrile fumarate (2:1) in combination with controlled loading improved scar remodeling and tendon wound collagen maturation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    256.26

    分子式

    C4H4O4.2C3H6N2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NCCC#N.OC(/C=C/C(O)=O)=O.NCCC#N
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (390.23 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9023 mL 19.5114 mL 39.0229 mL
    5 mM 0.7805 mL 3.9023 mL 7.8046 mL
    10 mM 0.3902 mL 1.9511 mL 3.9023 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (390.23 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.96%

    COA (251 KB) HNMR (244 KB) RP-HPLC (206 KB) MS (248 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [1]

    Horses[1]
    Seven female and nine male horses are assigned at random to two groups (G1 and G2) submitted to different treatments after the induction of acute tendinitis. Each group consists of eight animals injected with type 1 collagenase, 1 mL, 2.5 mg/mL, in the middle metacarpal third into the superficial digital flexor tendons of both forelimbs. Twenty days after the injection of collagenase, one of the limbs (G1A/G2A) receives an injection of 3-Aminopropionitrile fumarate (2:1), 3 mL, 0.8 mg/mL, and the other limb (G1B) receives the same volume of buffered saline as control. Group one was left in box rest, and group two was submitted to controlled exercise during the experiment[1].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.9023 mL 19.5114 mL 39.0229 mL 97.5572 mL
    5 mM 0.7805 mL 3.9023 mL 7.8046 mL 19.5114 mL
    10 mM 0.3902 mL 1.9511 mL 3.9023 mL 9.7557 mL
    15 mM 0.2602 mL 1.3008 mL 2.6015 mL 6.5038 mL
    20 mM 0.1951 mL 0.9756 mL 1.9511 mL 4.8779 mL
    25 mM 0.1561 mL 0.7805 mL 1.5609 mL 3.9023 mL
    30 mM 0.1301 mL 0.6504 mL 1.3008 mL 3.2519 mL
    40 mM 0.0976 mL 0.4878 mL 0.9756 mL 2.4389 mL
    50 mM 0.0780 mL 0.3902 mL 0.7805 mL 1.9511 mL
    60 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6260 mL
    80 mM 0.0488 mL 0.2439 mL 0.4878 mL 1.2195 mL
    100 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9756 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    3-Aminopropionitrile fumarate (2:1) Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    3-Aminopropionitrile fumarate (2:1)2079-89-2Di-β-aminopropionitrileβ-Aminopropionitrile β-Ammoniumpropionitrile hemifumarateMMPMatrix metalloproteinasesInhibitorinhibitorinhibit

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