Avibactam sodium (Synonyms: NXL-104)

Name: Avibactam sodium
Brand: MedChemExpress
SKU: HY-14879A
Rating: 5.0 (92 reviews)

Cat. No.: HY-14879A Purity: 99.99%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 1192491-61-4

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	견적 받기
1 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 92 publication(s) in Google Scholar

Other Forms of Avibactam sodium:

92 Publications Citing Use of MCE Avibactam sodium

Bio/Physico-chemical Assay

RT-PCR

In Vivo Efficacy Study

Cell Proliferation/Viability Assay

: Avibactam sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]; SREBP2 target gene transcript levels after treatment with Avibactam (0.69 μM, 24 h) analyzed by qPCR. Actin Beta (ACTB) was used as a reference gene.

: Avibactam sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]; S-acylation levels of SCAP in Huh7 cells treated with Avibactam (0.69 μM, 24 h).

: Avibactam sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]; Protein levels of SCAP and its downstream target proteins in Huh7 cells following treatment with Avibactam (0.69 μM, 24 h).

: Avibactam sodium purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2022 Sep 30;77(10):2803-2808. [Abstract]; In vivo change in log10 cfu/thigh of each isolate treated with saline control, Ceftazidime 2 g IV q8h 2 h infusion HSR, Ceftazidime/Avibactam 2.5 g q8h 2 h infusion HSR or meropenem 2 g q8h 3 h infusion HSR for three P. aeruginosa with inserted GES β-lactamases. (a) PSA 2136, with inserted GES-1 (ESBL). (b) PSA 2137, with inserted GES-5 (carbapenemase). (c) PSA 2138, with inserted GES-15. P values in the boxes represent the results from one-way ANOVA; P values are presented if between-group differences were present. The x-axis describes the treatment HSR [MIC (mg/L), % fT>MIC]. CAZ, Ceftazidime; CAZ-AVI, Ceftazidime/Avibactam; MEM, meropenem.

: Avibactam sodium purchased from MedChemExpress. Usage Cited in: Biosens Bioelectron. 2021 Dec 1:193:113526. [Abstract]; Avibactam sodium (AVI: 6.3-50 mg/L) in the presence or absence of 200 mg/L ceftriaxone and/or 0.8 U/L CTX-M-14.

: Avibactam sodium purchased from MedChemExpress. Usage Cited in: Biosens Bioelectron. 2021 Dec 1:193:113526. [Abstract]; Analysis of mixed mock samples containing 0.8 U/L each of NDM-1/CTX-M-14 were incubated with penicillin, ceftriaxone, cefepime, cefoxitin or meropenem (200 mg/L) in the presence and absence of 25 mg/L Avibactam sodium (AVI) for 15 min, then the NDM-1/CTX-M-14 treated and untreated antibiotic samples were analyzed.

: Avibactam sodium purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936. [Abstract]; Total β-lactamase activity for bacterial lysates is measured using the chromogenic substrate nitrocefin, with or without Avibactam at 4 mg/L. (b) GR20263 hydrolysis activity of different bacterial lysates is determined with or without Avibactam at 4 mg/L.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

IC₅₀: 5 nM (CTX-M-15), 8 nM (TEM-1)^[1]

In Vitro

Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases^[2].
Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 bla_KPC-2 positive and 1 of bla_OXA-232 positive Klebsiella pneumonia growth with MIC₅₀ and MIC₉₀ for both 8?mg/L^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ceftazidime-Avibactam (0.375?mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model^[3].
Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model^[4]
Dosage:	0.375 mg/g in combination with Ceftazidime
Administration:	Subcutaneous injection, 4 h post infection and given every 8 h for 10 days
Result:	70% of infection group mice died within 4 days, and all mice in the PBS group died within 13 days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8 h, whereas 100% of mice in this group died within 4 days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.

분자량

287.23

화학식

C₇H₁₀N₃NaO₆S

CAS No.

1192491-61-4

Appearance

Solid

Color

White to off-white

SMILES

O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 125 mg/mL (435.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (174.08 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4815 mL	17.4077 mL	34.8153 mL
5 mM	0.6963 mL	3.4815 mL	6.9631 mL
10 mM	0.3482 mL	1.7408 mL	3.4815 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.99%

Select Batch:

Data Sheet (280 KB) SDS (394 KB)

COA (254 KB) HNMR (280 KB) RP-HPLC (268 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Ehmann DE, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8. [Content Brief]

[2]. Livermore DM, et al. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J Antimicrob Chemother. 2012 Jun;67(6):1354-8. [Content Brief]

[3]. Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304. [Content Brief]

[4]. Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.4815 mL	17.4077 mL	34.8153 mL	87.0383 mL
	5 mM	0.6963 mL	3.4815 mL	6.9631 mL	17.4077 mL
	10 mM	0.3482 mL	1.7408 mL	3.4815 mL	8.7038 mL
	15 mM	0.2321 mL	1.1605 mL	2.3210 mL	5.8026 mL
	20 mM	0.1741 mL	0.8704 mL	1.7408 mL	4.3519 mL
	25 mM	0.1393 mL	0.6963 mL	1.3926 mL	3.4815 mL
	30 mM	0.1161 mL	0.5803 mL	1.1605 mL	2.9013 mL
	40 mM	0.0870 mL	0.4352 mL	0.8704 mL	2.1760 mL
	50 mM	0.0696 mL	0.3482 mL	0.6963 mL	1.7408 mL
	60 mM	0.0580 mL	0.2901 mL	0.5803 mL	1.4506 mL
	80 mM	0.0435 mL	0.2176 mL	0.4352 mL	1.0880 mL
	100 mM	0.0348 mL	0.1741 mL	0.3482 mL	0.8704 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Avibactam sodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avibactam1192491-61-4NXL-104NXL104NXL 104Beta-lactamaseBacterialAntibioticβ-lactamaseTEM-1CTX-M-15antibacterialKlebsiella pneumoniaPseudomonas aeruginosaInhibitorinhibitorinhibit

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Avibactam sodium (Synonyms: NXL-104)

고객리뷰

Other Forms of Avibactam sodium:

Avibactam sodium Related Antibodies

92 Publications Citing Use of MCE Avibactam sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Beta-lactamase Isoform Specific Products:

View All Antibiotic Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Avibactam sodium Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Avibactam sodium Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report