2. Anti-infection
  3. Bacterial Antibiotic
  4. Bedaquiline

Bedaquiline  (Synonyms: TMC207; R207910)

製品番号: HY-14881 純度: 99.98%
COA 取扱説明書 Technical Support

Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis.

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CAS 番号 : 843663-66-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 73 在庫あり
Solution
10 mM * 1 mL in DMSO USD 73 在庫あり
Solid
5 mg $60 在庫あり
10 mg $90 在庫あり
25 mg $143 在庫あり
50 mg $190 在庫あり
100 mg $250 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 54 publication(s) in Google Scholar

Other Forms of Bedaquiline:

Bedaquiline 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Imaging/Staining
Microbiological Assay

    Bedaquiline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 10;16(1):4366.  [Abstract]

    Bedaquiline (BDQ) was effective on susceptible M. smegmatis already at 1× MIC (0.05 μg/mL).

    Bedaquiline purchased from MedChemExpress. Usage Cited in: J Clin Microbiol. 2025 Aug 20:e0084125.  [Abstract]

    M. abscessus bedaquiline MIC90 values from TM4::GeNL DST, Sensititre RAPMYCO2 DST, MAB_2299c gene mutation-sMAB_4384 and MAB_2299c genotypes. Among the isolates tested, 35% (9/26) demonstrated Bedaquiline (BDQ) MICs greater than 0.5 µg/mL.

    Bedaquiline purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Oct 6;8(1):1425.  [Abstract]

    Minimum Inhibitory Concentration (MIC) determination of the ΔcysE in comparison to WT and Complement strains against anti-TB drugs: Bedaquilline (BDQ) (7 days).

    Bedaquiline purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 Sep 11:e0079525.  [Abstract]

    Bedaquiline (BDQ) showed efficacy against Mtb in activated BMDMhs. Macrophages were infected with bacteria and treated with BDQ (0.63 and 2.5 μg/mL, 0-12 days).

    Bedaquiline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Jun 21;12(1):3816.  [Abstract]

    Bedaquiline (BDQ) (2.5 μg/mL, 24 h) significantly enhanced Pyrazinamide (PZA)/Pyrazinoic acid (POA) accumulation in intracellular Mtb.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2].

    IC50 & Target

    Mtb F1FO-ATP synthase[1]
    Cellular Effect
    Cell Line Type Value Description References
    HeLa CC50
    > 64 μg/mL
    Compound: 1; TMC207,R207910
    Cytotoxicity against human HeLa cells
    Cytotoxicity against human HeLa cells
    		[PMID: 35636648]
    Vero CC50
    > 50 μg/mL
    Compound: 1; TMC207,R207910
    Cytotoxicity against African green monkey Vero cells
    Cytotoxicity against African green monkey Vero cells
    		[PMID: 35636648]
    Vero IC50
    4 μg/mL
    Compound: 1; BDQ
    Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTS-PBS assay
    Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTS-PBS assay
    		[PMID: 31810890]
    Vero IC50
    > 10 μM
    Compound: 2
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTS/PMS assay
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTS/PMS assay
    		[PMID: 29259747]
    Vero IC50
    > 10 μg/mL
    Compound: 1
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTS-PMS assay
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTS-PMS assay
    		[PMID: 29107541]
    Vero IC50
    > 10 μg/mL
    Compound: 1; TMC207
    Cytotoxicity against African green monkey Vero cells measured after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
    Cytotoxicity against African green monkey Vero cells measured after 72 hrs by CellTiter 96 aqueous non-radioactive cell proliferation assay
    		[PMID: 30891129]
    Vero IC50
    > 10 μg/mL
    Compound: 1; TMC207, Sirturo
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTS-PMS assay
    Cytotoxicity against African green monkey Vero cells after 72 hrs by MTS-PMS assay
    		[PMID: 30792104]
    Vero IC50
    > 10 μg/mL
    Compound: 1; TMC207, Sirturo
    Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
    Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay
    		[PMID: 30803745]
    体外実験

    Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[2].
    Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[3].
    Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Bedaquiline 関連抗体
    臨床実験
    分子量

    555.50

    分子式

    C32H31BrN2O2
    CAS 番号
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    BrC1=CC=C(N=C(OC)C([C@H]([C@@](C2=CC=CC3=C2C=CC=C3)(O)CCN(C)C)C4=CC=CC=C4)=C5)C5=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 12.5 mg/mL (22.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8002 mL 9.0009 mL 18.0018 mL
    5 mM 0.3600 mL 1.8002 mL 3.6004 mL
    10 mM 0.1800 mL 0.9001 mL 1.8002 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 0.5 mg/mL (0.90 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 0.5 mg/mL (0.90 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 0.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.98%

    COA (253 KB) HNMR (296 KB) RP-HPLC (315 KB) MS (69 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.8002 mL 9.0009 mL 18.0018 mL 45.0045 mL
    5 mM 0.3600 mL 1.8002 mL 3.6004 mL 9.0009 mL
    10 mM 0.1800 mL 0.9001 mL 1.8002 mL 4.5005 mL
    15 mM 0.1200 mL 0.6001 mL 1.2001 mL 3.0003 mL
    20 mM 0.0900 mL 0.4500 mL 0.9001 mL 2.2502 mL
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    Bedaquiline Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bedaquiline843663-66-1TMC207 R207910TMC 207TMC-207R207910R 207910R-207910BacterialAntibioticInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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