2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. D-Pantothenic acid sodium

D-Pantothenic acid sodium  (Synonyms: Sodium pantothenate; Vitamin B5 sodium)

Cat. No.: HY-B0430A Assay: 99.5%
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SDS
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D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.

For research use only. We do not sell to patients.

CAS No. : 867-81-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
100 mg In-stock
500 mg In-stock
1 g In-stock
5 g In-stock
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50 g   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of D-Pantothenic acid sodium:

D-Pantothenic acid sodium Related Antibodies

Top Publications Citing Use of Products

    D-Pantothenic acid sodium purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    The effect of concentration gradients (0 μM, 0.1 μM, 1 μM, and10μM) of PA (D-Pantothenic acid) against FN, COL1A1, ACTA2, and IGFBP6 in TGF-β (10 ng/mL) -stimulated LX2 cells was examined using qRT-PCR for mRNA levels (n = 3).

    D-Pantothenic acid sodium purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    The effect of concentration gradients (0 μM, 0.1 μM, 1 μM, and10μM) of PA (D-Pantothenic acid) against FN, COL1A1, ACTA2, and IGFBP6 in TGF-β (10 ng/mL) -stimulated LX2 cells was examined using Western blotting for protein levels (n = 3).

    D-Pantothenic acid sodium purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    LX2 cells were treated with 1 μM PA (D-Pantothenic acid) in the presence or absence of MG132 for 12 h. IP detection was performed with anti-IGFBP6 antibody, and expression of ubiquitin-coupled IGFBP6 was detected with anti-UB antibody (n = 3).

    D-Pantothenic acid sodium purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    Weight loss in mice with hepatic fibrosis. Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

    D-Pantothenic acid sodium purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    H&E staining, Masson’s trichrome staining, and Sirius red staining of hepatic sections (scale bar: H&E staining, 100 μm; Masson’s trichrome staining and Sirius red staining, 200 μm). Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

    D-Pantothenic acid sodium purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    IHC was performed to detect the expression of α-SMA and COL1A1 in hepatic sections (scale bar: 50 μm) (n = 6). Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

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    • References

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    Description

    D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    D-Pantothenic acid sodium is a precursor to coenzyme A and is primarily involved in energy production and lipid metabolism through the TCA cycle and the β-oxidation pathway, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    D-Pantothenic acid sodium Related Antibodies
    In Vivo

    Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female ICR mice weighing 29-35 g[2]
    Dosage: 3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered)
    Administration: Injected intraperitoneally (i.p.) on day 8.5 of gestation
    Result: Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced.
    Molecular Weight

    241.22

    Formula

    C9H16NNaO5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OCC(C)(C)[C@@H](O)C(NCCC(O[Na])=O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (414.56 mM; Need ultrasonic)

    DMSO : 5 mg/mL (20.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.1456 mL 20.7280 mL 41.4559 mL
    5 mM 0.8291 mL 4.1456 mL 8.2912 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 0.5 mg/mL (2.07 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 0.5 mg/mL (2.07 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 120 mg/mL (497.47 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.5%

    SDS (393 KB)

    COA (244 KB) HNMR (117 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 4.1456 mL 20.7280 mL 41.4559 mL 103.6398 mL
    5 mM 0.8291 mL 4.1456 mL 8.2912 mL 20.7280 mL
    10 mM 0.4146 mL 2.0728 mL 4.1456 mL 10.3640 mL
    15 mM 0.2764 mL 1.3819 mL 2.7637 mL 6.9093 mL
    20 mM 0.2073 mL 1.0364 mL 2.0728 mL 5.1820 mL
    H2O 25 mM 0.1658 mL 0.8291 mL 1.6582 mL 4.1456 mL
    30 mM 0.1382 mL 0.6909 mL 1.3819 mL 3.4547 mL
    40 mM 0.1036 mL 0.5182 mL 1.0364 mL 2.5910 mL
    50 mM 0.0829 mL 0.4146 mL 0.8291 mL 2.0728 mL
    60 mM 0.0691 mL 0.3455 mL 0.6909 mL 1.7273 mL
    80 mM 0.0518 mL 0.2591 mL 0.5182 mL 1.2955 mL
    100 mM 0.0415 mL 0.2073 mL 0.4146 mL 1.0364 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    D-Pantothenic acid sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    D-Pantothenic acid867-81-2Sodium pantothenateVitamin B5Vitamin B 5Vitamin B-5ApoptosisEndogenous MetaboliteInhibitorinhibitorinhibit

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