D-Pantothenic acid (Synonyms: Pantothenate; Vitamin B5)

Name: D-Pantothenic acid
Brand: MedChemExpress
SKU: HY-B0430
Rating: 5.0 (6 reviews)

Cat. No.: HY-B0430 Purity: 98.0%: Data Sheet
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D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.

For research use only. We do not sell to patients.

CAS No. : 79-83-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of D-Pantothenic acid:

D-Pantothenic acid-¹³C₃,¹⁵N hemicalcium hemihydrate In-stock
Pantothenic acid-¹³C₃,¹⁵N hemicalcium In-stock
D-Pantothenic acid sodium In-stock
D-Pantothenic acid hemicalcium salt In-stock

6 Publications Citing Use of MCE D-Pantothenic acid

RT-PCR

In Vivo Efficacy Study

Histological Imaging/Staining

IHC

: D-Pantothenic acid purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]; The effect of concentration gradients (0 μM, 0.1 μM, 1 μM, and10μM) of PA (D-Pantothenic acid) against FN, COL1A1, ACTA2, and IGFBP6 in TGF-β (10 ng/mL) -stimulated LX2 cells was examined using qRT-PCR for mRNA levels (n = 3).

: D-Pantothenic acid purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]; The effect of concentration gradients (0 μM, 0.1 μM, 1 μM, and10μM) of PA (D-Pantothenic acid) against FN, COL1A1, ACTA2, and IGFBP6 in TGF-β (10 ng/mL) -stimulated LX2 cells was examined using Western blotting for protein levels (n = 3).

: D-Pantothenic acid purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]; LX2 cells were treated with 1 μM PA (D-Pantothenic acid) in the presence or absence of MG132 for 12 h. IP detection was performed with anti-IGFBP6 antibody, and expression of ubiquitin-coupled IGFBP6 was detected with anti-UB antibody (n = 3).

: D-Pantothenic acid purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]; Weight loss in mice with hepatic fibrosis. Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

: D-Pantothenic acid purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]; H&E staining, Masson’s trichrome staining, and Sirius red staining of hepatic sections (scale bar: H&E staining, 100 μm; Masson’s trichrome staining and Sirius red staining, 200 μm). Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

: D-Pantothenic acid purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127. [Abstract]; IHC was performed to detect the expression of α-SMA and COL1A1 in hepatic sections (scale bar: 50 μm) (n = 6). Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

D-Pantothenic acid sodium is a precursor to coenzyme A and is primarily involved in energy production and lipid metabolism through the TCA cycle and the β-oxidation pathway, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female ICR mice weighing 29-35 g^[2]
Dosage:	3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered)
Administration:	Injected intraperitoneally (i.p.) on day 8.5 of gestation
Result:	Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced.

Clinical Trial

Molecular Weight

219.24

Formula

C₉H₁₇NO₅

CAS No.

79-83-4

Appearance

Solid

Color

White to off-white

SMILES

OCC(C)(C)[C@@H](O)C(NCCC(O)=O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Animals

Microorganisms

widespread

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (228.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5612 mL	22.8061 mL	45.6121 mL
5 mM	0.9122 mL	4.5612 mL	9.1224 mL
10 mM	0.4561 mL	2.2806 mL	4.5612 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 100 mg/mL (456.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.96%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (244 KB) HNMR (254 KB) RP-HPLC (241 KB)

Handling Instructions (2659 KB)

References

[1]. Shuai Chen, et al. Metabolomic analysis of the toxic effect of chronic exposure of cadmium on rat urine. Environ Sci Pollut Res Int. 2018 Feb;25(4):3765-3774. [Content Brief]

[2]. M Sato, et al. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology. 1995 Sep;52(3):143-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5612 mL	22.8061 mL	45.6121 mL	114.0303 mL
	5 mM	0.9122 mL	4.5612 mL	9.1224 mL	22.8061 mL
	10 mM	0.4561 mL	2.2806 mL	4.5612 mL	11.4030 mL
	15 mM	0.3041 mL	1.5204 mL	3.0408 mL	7.6020 mL
	20 mM	0.2281 mL	1.1403 mL	2.2806 mL	5.7015 mL
	25 mM	0.1824 mL	0.9122 mL	1.8245 mL	4.5612 mL
	30 mM	0.1520 mL	0.7602 mL	1.5204 mL	3.8010 mL
	40 mM	0.1140 mL	0.5702 mL	1.1403 mL	2.8508 mL
	50 mM	0.0912 mL	0.4561 mL	0.9122 mL	2.2806 mL
	60 mM	0.0760 mL	0.3801 mL	0.7602 mL	1.9005 mL
	80 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4254 mL
	100 mM	0.0456 mL	0.2281 mL	0.4561 mL	1.1403 mL

D-Pantothenic acid Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Pantothenic acid79-83-4Pantothenate Vitamin B5Vitamin B5Vitamin B 5Vitamin B-5Environmental PollutantsEndogenous MetaboliteEnvironmental ContaminantsInhibitorinhibitorinhibit

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D-Pantothenic acid (Synonyms: Pantothenate; Vitamin B5)

Customer Review

Other Forms of D-Pantothenic acid:

D-Pantothenic acid Related Antibodies

6 Publications Citing Use of MCE D-Pantothenic acid

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

D-Pantothenic acid Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

D-Pantothenic acid Related Classifications

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