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  4. D-Pantothenic acid hemicalcium salt

D-Pantothenic acid hemicalcium salt  (Synonyms: Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt)

Cat. No.: HY-N0681 Purity: 99.80%
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D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity.

For research use only. We do not sell to patients.

CAS No. : 137-08-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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500 mg In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of D-Pantothenic acid hemicalcium salt:

D-Pantothenic acid hemicalcium salt Related Antibodies

Top Publications Citing Use of Products

    D-Pantothenic acid hemicalcium salt purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    The effect of concentration gradients (0 μM, 0.1 μM, 1 μM, and10μM) of PA (D-Pantothenic acid) against FN, COL1A1, ACTA2, and IGFBP6 in TGF-β (10 ng/mL) -stimulated LX2 cells was examined using qRT-PCR for mRNA levels (n = 3).

    D-Pantothenic acid hemicalcium salt purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    The effect of concentration gradients (0 μM, 0.1 μM, 1 μM, and10μM) of PA (D-Pantothenic acid) against FN, COL1A1, ACTA2, and IGFBP6 in TGF-β (10 ng/mL) -stimulated LX2 cells was examined using Western blotting for protein levels (n = 3).

    D-Pantothenic acid hemicalcium salt purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    LX2 cells were treated with 1 μM PA (D-Pantothenic acid) in the presence or absence of MG132 for 12 h. IP detection was performed with anti-IGFBP6 antibody, and expression of ubiquitin-coupled IGFBP6 was detected with anti-UB antibody (n = 3).

    D-Pantothenic acid hemicalcium salt purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    Weight loss in mice with hepatic fibrosis. Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

    D-Pantothenic acid hemicalcium salt purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    H&E staining, Masson’s trichrome staining, and Sirius red staining of hepatic sections (scale bar: H&E staining, 100 μm; Masson’s trichrome staining and Sirius red staining, 200 μm). Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

    D-Pantothenic acid hemicalcium salt purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 Jul 29;8(1):1127.  [Abstract]

    IHC was performed to detect the expression of α-SMA and COL1A1 in hepatic sections (scale bar: 50 μm) (n = 6). Mice received intraperitoneal injections with gradually increasing concentrations of TAA and were simultaneously treated with PA (D-Pantothenic acid) by gavage (n = 6).

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity[1][2][3][4][5][6][7][8].
    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    D-Pantothenic acid (Vitamin B5, 1-2.5 mM) hemicalcium salt restrains Th17 cell differentiation through CoA in a PANK-dependent manner[3].
    D-Pantothenic acid (50-1000 µM, 3 days) hemicalcium salt inhibits RANKL induced osteoclastogenesis by scavenging ROS generation in BMMs cells[5].
    D-Pantothenic acid (2  mM, 4 days) hemicalcium salt rescues a membrane trafficking defect in human fibroblasts devoid of TANGO2[8].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    D-Pantothenic acid hemicalcium salt Related Antibodies
    In Vivo

    D-Pantothenic acid hemicalcium salt (10 mg/kg, oral gavage, daily) protects against obesity via brown adipose tissue activation in C57BL/6J mice[4].
    D-Pantothenic acid (Vitamin B5, 50mg/kg/day, drinking water, 2 weeks) hemicalcium salt alleviates experimental autoimmune encephalomyelitis in C57BL/6 mice[3].
    D-Pantothenic acid (pantothenic acid rich dietary, feed, four weeks) hemicalcium salt alleviates bone loss in an osteoporotic model of OVX mice[5].
    D-Pantothenic acid (0.1 mg/kg, p.o., starts from the day after infection and performs every day until the end of 4 weeks) hemicalcium salt reduces bacterial growth via regulating innate immunity and adaptive immunity in mice infected with mycobacterium tuberculosis[6].
    D-Pantothenic acid (50  ppm, diet, 28 days) hemicalcium salt enhances intestinal development and alters microbes in weaned piglets, with enhancing the morphological structure, cell proliferation and differentiation of the ileum, cecum and colon[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    238.27

    Formula

    C9H16NO5.1/2Ca
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@H](C(NCCC([O-])=O)=O)C(C)(C)CO.[0.5Ca2+]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (419.69 mM; Need ultrasonic)

    DMSO : ≥ 100 mg/mL (419.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.1969 mL 20.9846 mL 41.9692 mL
    5 mM 0.8394 mL 4.1969 mL 8.3938 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    Volume (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (419.69 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.80%

    SDS (393 KB)

    COA (249 KB) HNMR (133 KB) RP-HPLC (137 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 4.1969 mL 20.9846 mL 41.9692 mL 104.9230 mL
    5 mM 0.8394 mL 4.1969 mL 8.3938 mL 20.9846 mL
    10 mM 0.4197 mL 2.0985 mL 4.1969 mL 10.4923 mL
    15 mM 0.2798 mL 1.3990 mL 2.7979 mL 6.9949 mL
    20 mM 0.2098 mL 1.0492 mL 2.0985 mL 5.2461 mL
    25 mM 0.1679 mL 0.8394 mL 1.6788 mL 4.1969 mL
    30 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4974 mL
    40 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6231 mL
    50 mM 0.0839 mL 0.4197 mL 0.8394 mL 2.0985 mL
    60 mM 0.0699 mL 0.3497 mL 0.6995 mL 1.7487 mL
    80 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3115 mL
    100 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0492 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    D-Pantothenic acid hemicalcium salt Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    D-Pantothenic acid hemicalcium137-08-6Calcium pantothenate Calcium D-pantothenateVitamin B5Vitamin B 5Vitamin B-5Environmental PollutantsEndogenous MetaboliteApoptosisEnvironmental ContaminantsOsteoporosisObesityAntibacterial and Immunomodulatory.Inhibitorinhibitorinhibit

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