2. Anti-infection Immunology/Inflammation
  3. Fungal Bacterial Interleukin Related
  4. Dihydrosanguinarine

Dihydrosanguinarine  (Synonyms: 13,14-Dihydrosanguinarine)

Cat. No.: HY-N0902 Purity: 99.98%
COA
SDS
Handling Instructions Technical Support

Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis.

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Dihydrosanguinarine

Dihydrosanguinarine 화학구조

CAS No. : 3606-45-9

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Dihydrosanguinarine Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis[1][2].

IC50 & Target[2]

IL-6

 

IL-17A

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
>30 3
Compound: 2; DHSA
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33479636]
A549 IC50
> 30 3
Compound: 2; DHSA
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33479636]
A549 IC50
> 30 3
Compound: 2; DHSA
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33479636]
NCI-H1975 IC50
19.14 3
Compound: 2; DHSA
Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33479636]
NCI-H1975 IC50
19.14 3
Compound: 2; DHSA
Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33479636]
NCI-H1975 IC50
19.14 3
Compound: 2; DHSA
Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33479636]
In Vitro

Dihydrosanguinarine shows antibacterial activity against oral aerobic and anaerobic microorganisms with a minimum inhibitory concentration of 140-150 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrosanguinarine Related Antibodies
In Vivo

Dihydrosanguinarine (10-20 mg/kg) protects against LPS-triggered hepatitis in male BALB/c mice by reducing inflammatory pathology, modulating key cytokine levels, and regulating mRNA expression of inflammation-related genes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

333.34

화학식

C20H15NO4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN1C2=C(C=C(OCO3)C3=C4)C4=CC=C2C5=CC=C6C(OCO6)=C5C1
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
용액&용해도
In Vitro: 

DMSO : 12.5 mg/mL (37.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9999 mL 14.9997 mL 29.9994 mL
5 mM 0.6000 mL 2.9999 mL 5.9999 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.98%

SDS (393 KB)

COA (249 KB) HNMR (257 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9999 mL 14.9997 mL 29.9994 mL 74.9985 mL
5 mM 0.6000 mL 2.9999 mL 5.9999 mL 14.9997 mL
10 mM 0.3000 mL 1.5000 mL 2.9999 mL 7.4999 mL
15 mM 0.2000 mL 1.0000 mL 2.0000 mL 4.9999 mL
20 mM 0.1500 mL 0.7500 mL 1.5000 mL 3.7499 mL
25 mM 0.1200 mL 0.6000 mL 1.2000 mL 2.9999 mL
30 mM 0.1000 mL 0.5000 mL 1.0000 mL 2.5000 mL
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Dihydrosanguinarine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrosanguinarine3606-45-913,14-DihydrosanguinarineFungalBacterialInterleukin RelatedILPapaver bracteatum callus culturesPapaver bracteatum suspension culturesLPS-triggered hepatitisTNF/IL-17/PI3K signaling pathwaysAlternaria longipesoral aerobic microorganismsmacrophagemicroorganismsoral anaerobic microorganismsmale BALB/c miceInhibitorinhibitorinhibit

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상품명:
Dihydrosanguinarine
Cat. No.:
HY-N0902
수량:
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SAFETY DATA SHEET (SDS)

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