2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. Docosanoic acid

ベヘン酸  (Synonyms: Docosanoic acid; ドコサン酸)

製品番号: HY-W013049 純度: 99.40%
COA 取扱説明書 Technical Support

Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.

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Docosanoic acid

ベヘン酸 構造式

CAS 番号 : 112-85-6

容量 価格（税別） 在庫状況 数量
100 mg $30 在庫あり
500 mg $48 在庫あり
1 g $62 在庫あり
5 g $100 在庫あり
10 g $130 在庫あり
25 g $182 在庫あり
50 g $220 在庫あり
100 g $264 在庫あり
> 100 g   お問い合わせ  

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Other Forms of Docosanoic acid:

ベヘン酸 関連抗体

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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製品説明

Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

Docosanoic acid is effective at inhibiting the dsDNA binding activity of wild-type p53 DBD, with 50% inhibition observed at 0.41 nmol. The inhibitory effect of Docosanoic acid on the activities of R248A mutant p53 DBD was almost as strong as that of the wild-type[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ベヘン酸 関連抗体
体内実験

In rats, the percentage of Behenic acid in the diet is 1.7% and shows a significant reduction in the deposition of visceral fat, confirmed by a lower weight of adipose (epididymal and mesenteric) and hepatic tissues, as well as excreting more fatty acids in the feces when compared to the group. Behenic acid has a low bioavailability, which leads to a reduction in the absorption and as a consequence, to the reduction in body weight and deposition of visceral fat[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.59

分子式

C22H44O2
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCCCCCCCCCCCCCCCCCCCCC(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMF : 9.09 mg/mL (26.69 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (2.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9361 mL 14.6804 mL 29.3608 mL
5 mM 0.5872 mL 2.9361 mL 5.8722 mL
10 mM 0.2936 mL 1.4680 mL 2.9361 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 3.33 mg/mL (9.78 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.40%

COA (237 KB) HNMR (236 KB) RP-HPLC (248 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 2.9361 mL 14.6804 mL 29.3608 mL 73.4020 mL
DMF 5 mM 0.5872 mL 2.9361 mL 5.8722 mL 14.6804 mL
10 mM 0.2936 mL 1.4680 mL 2.9361 mL 7.3402 mL
15 mM 0.1957 mL 0.9787 mL 1.9574 mL 4.8935 mL
20 mM 0.1468 mL 0.7340 mL 1.4680 mL 3.6701 mL
25 mM 0.1174 mL 0.5872 mL 1.1744 mL 2.9361 mL
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Docosanoic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Docosanoic acid112-85-6Behenic acidEndogenous MetaboliteDNA/RNA SynthesisInhibitorinhibitorinhibit

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