Methyl vanillate (Synonyms: バニリン酸メチル; 4-ヒドロキシ-3-メトキシ安息香酸メチル)

Name: Methyl vanillate
Brand: MedChemExpress
SKU: HY-75342
Rating: 5.0 (2 reviews)

製品番号: HY-75342 純度: 99.88%: Data Sheet SDS COA 取扱説明書
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Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Methyl vanillate 構造式

CAS 番号 : 3943-74-6

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	在庫あり	Estimated Time of Arrival: December 31
Solid
500 mg	$30	在庫あり	Estimated Time of Arrival: December 31
1 g	$40	在庫あり	Estimated Time of Arrival: December 31
5 g	$60	在庫あり	Estimated Time of Arrival: December 31
10 g	$75	在庫あり	Estimated Time of Arrival: December 31
25 g	$110	在庫あり	Estimated Time of Arrival: December 31
50 g	$140	在庫あり	Estimated Time of Arrival: December 31
100 g	$185	在庫あり	Estimated Time of Arrival: December 31
> 100 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Methyl vanillate:

Methyl vanillate-d₃ お問い合わせ
Methyl vanillate (Standard) お問い合わせ

顧客検証

Wnt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator^[1]. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human A549 cells after 24 hrs by MTT assay Anticancer activity against human A549 cells after 24 hrs by MTT assay	[PMID: 20466556]
A549	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against human A549 cells after 24 hrs by MTT assay Anticancer activity against human A549 cells after 24 hrs by MTT assay	[PMID: 20466556]
A549	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human A549 cells after 24 hrs by MTT assay Anticancer activity against human A549 cells after 24 hrs by MTT assay	[PMID: 20466556]
B16-F10	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against mouse B16F10 cells after 24 hrs by MTT assay Anticancer activity against mouse B16F10 cells after 24 hrs by MTT assay	[PMID: 20466556]
B16-F10	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against mouse B16F10 cells after 24 hrs by MTT assay Anticancer activity against mouse B16F10 cells after 24 hrs by MTT assay	[PMID: 20466556]
B16-F10	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against mouse B16F10 cells after 24 hrs by MTT assay Anticancer activity against mouse B16F10 cells after 24 hrs by MTT assay	[PMID: 20466556]
Hs 683	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against human Hs683 cells after 24 hrs by MTT assay Anticancer activity against human Hs683 cells after 24 hrs by MTT assay	[PMID: 20466556]
Hs 683	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human Hs683 cells after 24 hrs by MTT assay Anticancer activity against human Hs683 cells after 24 hrs by MTT assay	[PMID: 20466556]
LoVo	IC₅₀	83 3 Compound: 1bMe	Anticancer activity against human LoVo cells after 24 hrs by MTT assay Anticancer activity against human LoVo cells after 24 hrs by MTT assay	[PMID: 20466556]
Hs 683	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human Hs683 cells after 24 hrs by MTT assay Anticancer activity against human Hs683 cells after 24 hrs by MTT assay	[PMID: 20466556]
LoVo	IC₅₀	83 3 Compound: 1bMe	Anticancer activity against human LoVo cells after 24 hrs by MTT assay Anticancer activity against human LoVo cells after 24 hrs by MTT assay	[PMID: 20466556]
LoVo	IC₅₀	83 3 Compound: 1bMe	Anticancer activity against human LoVo cells after 24 hrs by MTT assay Anticancer activity against human LoVo cells after 24 hrs by MTT assay	[PMID: 20466556]
MCF7	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against human MCF7 cells after 24 hrs by MTT assay Anticancer activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 20466556]
MCF7	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human MCF7 cells after 24 hrs by MTT assay Anticancer activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 20466556]
MCF7	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human MCF7 cells after 24 hrs by MTT assay Anticancer activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 20466556]
OE33	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against human OE33 cells after 24 hrs by MTT assay Anticancer activity against human OE33 cells after 24 hrs by MTT assay	[PMID: 20466556]
OE33	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human OE33 cells after 24 hrs by MTT assay Anticancer activity against human OE33 cells after 24 hrs by MTT assay	[PMID: 20466556]
PC-3	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against human PC3 cells after 24 hrs by MTT assay Anticancer activity against human PC3 cells after 24 hrs by MTT assay	[PMID: 20466556]
PC-3	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human PC3 cells after 24 hrs by MTT assay Anticancer activity against human PC3 cells after 24 hrs by MTT assay	[PMID: 20466556]
OE33	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human OE33 cells after 24 hrs by MTT assay Anticancer activity against human OE33 cells after 24 hrs by MTT assay	[PMID: 20466556]
PC-3	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human PC3 cells after 24 hrs by MTT assay Anticancer activity against human PC3 cells after 24 hrs by MTT assay	[PMID: 20466556]
RBL-2H3	IC₅₀	640 3 Compound: 1	Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay	[PMID: 27324979]
RBL-2H3	IC₅₀	640 3 Compound: 1	Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay	[PMID: 27324979]
RBL-2H3	IC₅₀	640 3 Compound: 1	Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay Anti-allergic activity in RBL2H3 cells assessed as inhibition of anti-DNP-IgE-induced degranulation incubated for 20 mins followed by DNP-labeled human serum albumin addition measured after 1 hr by beta-hexosaminidase release assay	[PMID: 27324979]
T98G	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against human T98G cells after 24 hrs by MTT assay Anticancer activity against human T98G cells after 24 hrs by MTT assay	[PMID: 20466556]
T98G	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human T98G cells after 24 hrs by MTT assay Anticancer activity against human T98G cells after 24 hrs by MTT assay	[PMID: 20466556]
T98G	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human T98G cells after 24 hrs by MTT assay Anticancer activity against human T98G cells after 24 hrs by MTT assay	[PMID: 20466556]
U-373MG ATCC	IC₅₀	>100 3 Compound: 1bMe	Anticancer activity against human U373 cells after 24 hrs by MTT assay Anticancer activity against human U373 cells after 24 hrs by MTT assay	[PMID: 20466556]
U-373MG ATCC	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human U373 cells after 24 hrs by MTT assay Anticancer activity against human U373 cells after 24 hrs by MTT assay	[PMID: 20466556]
U-373MG ATCC	IC₅₀	> 100 3 Compound: 1bMe	Anticancer activity against human U373 cells after 24 hrs by MTT assay Anticancer activity against human U373 cells after 24 hrs by MTT assay	[PMID: 20466556]

体外実験

Methyl vanillate (0-100 μM) increases the expression and nuclear translocation of β-catenin in calvarial osteoblasts. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

182.17

分子式

C₉H₁₀O₄

CAS 番号

3943-74-6

Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(OC)C(C=C1)=CC(OC)=C1O

Structure Classification

Initial Source

Microorganisms

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (548.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1.67 mg/mL (9.17 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4894 mL	27.4469 mL	54.8938 mL
5 mM	1.0979 mL	5.4894 mL	10.9788 mL
10 mM	0.5489 mL	2.7447 mL	5.4894 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 2 mg/mL (10.98 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.88%

Select Batch:

データシート (274 KB) SDS (393 KB)

COA (248 KB) HNMR (231 KB) RP-HPLC (267 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Cha PH, et al. Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. PLoS One. 2014 Jan 22;9(1):e85546. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	5.4894 mL	27.4469 mL	54.8938 mL	137.2345 mL
H₂O / DMSO	5 mM	1.0979 mL	5.4894 mL	10.9788 mL	27.4469 mL
DMSO	10 mM	0.5489 mL	2.7447 mL	5.4894 mL	13.7234 mL
	15 mM	0.3660 mL	1.8298 mL	3.6596 mL	9.1490 mL
	20 mM	0.2745 mL	1.3723 mL	2.7447 mL	6.8617 mL
	25 mM	0.2196 mL	1.0979 mL	2.1958 mL	5.4894 mL
	30 mM	0.1830 mL	0.9149 mL	1.8298 mL	4.5745 mL
	40 mM	0.1372 mL	0.6862 mL	1.3723 mL	3.4309 mL
	50 mM	0.1098 mL	0.5489 mL	1.0979 mL	2.7447 mL
	60 mM	0.0915 mL	0.4574 mL	0.9149 mL	2.2872 mL
	80 mM	0.0686 mL	0.3431 mL	0.6862 mL	1.7154 mL
	100 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.3723 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Methyl vanillate Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl vanillate3943-74-6WntReactive Oxygen Species (ROS)Endogenous MetaboliteInhibitorinhibitorinhibit

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Methyl vanillate (Synonyms: バニリン酸メチル; 4-ヒドロキシ-3-メトキシ安息香酸メチル)

カスタマーレビュー

Other Forms of Methyl vanillate:

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Wnt アイソフォーム固有の製品をすべて表示:

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Methyl vanillate Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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Methyl vanillate (Synonyms: バニリン酸メチル; 4-ヒドロキシ-3-メトキシ安息香酸メチル)

カスタマーレビュー

Other Forms of Methyl vanillate:

Methyl vanillate 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Wnt アイソフォーム固有の製品をすべて表示:

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Methyl vanillate 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Methyl vanillate Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

カスタマーレビュー

Request for HNMR Report

Request for HNMR Report