SAR7334

Name: SAR7334
Brand: MedChemExpress
SKU: HY-15699
Rating: 5.0 (21 reviews)

Cat. No.: HY-15699 Purity: 99.21%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 1333210-07-3

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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고객리뷰

Based on 21 publication(s) in Google Scholar

Other Forms of SAR7334:

SAR7334 hydrochloride In-stock

21 Publications Citing Use of MCE SAR7334

: SAR7334 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Oct 3;9(10):1015. [Abstract]; HK-2 cells are treated with different concentrations of SAR7334 for 12 h. Representative western blot images and the relative quantification of LC3-II are shown.

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View All TRP Channel Isoform Specific Products:

View All Isoforms

TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

Biological Activity
순도&문서
References
고객리뷰

제품 설명

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.

IC₅₀ & Target

IC50: 7.9 nM (TRPC6 currents)^[3]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	282 1 Compound: 52; SAR7334	Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
HEK293	IC₅₀	7.9 1 Compound: 52; SAR7334	Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp	[PMID: 30943030]
CHO	IC₅₀	282 1 Compound: 52; SAR7334	Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
HEK293	IC₅₀	9.5 1 Compound: 52; SAR7334	Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
HEK293	IC₅₀	226 1 Compound: 52; SAR7334	Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
HEK293	IC₅₀	226 1 Compound: 52; SAR7334	Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
HEK293	IC₅₀	226 1 Compound: 52; SAR7334	Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
HEK293	IC₅₀	7.9 1 Compound: 52; SAR7334	Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp	[PMID: 30943030]
HEK293	IC₅₀	7.9 1 Compound: 52; SAR7334	Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp	[PMID: 30943030]
HEK293	IC₅₀	9.5 1 Compound: 52; SAR7334	Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
CHO	IC₅₀	282 1 Compound: 52; SAR7334	Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]
HEK293	IC₅₀	9.5 1 Compound: 52; SAR7334	Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay	[PMID: 30943030]

In Vitro

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca²⁺ influx into cells with IC₅₀s of 9.5, 282 and 226 nM^[1]^[2]^[3], whereas TRPC4 and TRPC5-mediated Ca²⁺ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes^[1]. SAR7334 (1 μM) has negligible effect on SOCE^[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀ of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

367.87

화학식

C₂₁H₂₂ClN₃O

CAS No.

1333210-07-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

N[C@@H](C1)CCCN1[C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(Cl)C=C(C#N)C=C4

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : ≥ 370 mg/mL (1005.79 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7184 mL	13.5918 mL	27.1835 mL
5 mM	0.5437 mL	2.7184 mL	5.4367 mL
10 mM	0.2718 mL	1.3592 mL	2.7184 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

순도&문서

Purity: 99.21%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (256 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299. [Content Brief]

[2]. Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486. [Content Brief]

[3]. Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172(14):3650-60. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7184 mL	13.5918 mL	27.1835 mL	67.9588 mL
	5 mM	0.5437 mL	2.7184 mL	5.4367 mL	13.5918 mL
	10 mM	0.2718 mL	1.3592 mL	2.7184 mL	6.7959 mL
	15 mM	0.1812 mL	0.9061 mL	1.8122 mL	4.5306 mL
	20 mM	0.1359 mL	0.6796 mL	1.3592 mL	3.3979 mL
	25 mM	0.1087 mL	0.5437 mL	1.0873 mL	2.7184 mL
	30 mM	0.0906 mL	0.4531 mL	0.9061 mL	2.2653 mL
	40 mM	0.0680 mL	0.3398 mL	0.6796 mL	1.6990 mL
	50 mM	0.0544 mL	0.2718 mL	0.5437 mL	1.3592 mL
	60 mM	0.0453 mL	0.2265 mL	0.4531 mL	1.1326 mL
	80 mM	0.0340 mL	0.1699 mL	0.3398 mL	0.8495 mL
	100 mM	0.0272 mL	0.1359 mL	0.2718 mL	0.6796 mL

SAR7334 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR73341333210-07-3SAR 7334SAR-7334TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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SAR7334

고객리뷰

Other Forms of SAR7334:

SAR7334 Related Antibodies

21 Publications Citing Use of MCE SAR7334

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All TRP Channel Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

SAR7334 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

SAR7334 Related Classifications

Keywords:

최근 본 상품:

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