2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase
  5. 5-LOX Isoform
  6. 5-LOX Inhibitor

5-LOX Inhibitor

5-LOX Inhibitors (39):

Cat. No. Product Name Effect Purity
  • HY-13419
    U-73122
    		Inhibitor 98.17%
    U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC.
  • HY-14164
    Zileuton
    		Inhibitor 99.86%
    Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
  • HY-N0551
    Wedelolactone
    		Inhibitor 99.91%
    Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex.
  • HY-N0198
    Nordihydroguaiaretic acid
    		Inhibitor 99.88%
    Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
  • HY-N0172
    Caffeic acid
    		Inhibitor 99.16%
    Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).
  • HY-119671
    BW 755C
    		Inhibitor
    BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM.
  • HY-N0232
    Psoralidin
    		Inhibitor 99.90%
    Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.
  • HY-19807
    Indirubin-3'-monoxime
    		Inhibitor 99.89%
    Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
  • HY-B1452
    Licofelone
    		Inhibitor ≥99.0%
    Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis.
  • HY-12886
    Docebenone
    		Inhibitor 99.31%
    Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
  • HY-N0493
    Pectolinarigenin
    		Inhibitor 99.59%
    Pectolinarigenin is a dual inhibitor of COX-2/5-LOX.
  • HY-117048
    PF-4191834
    		Inhibitor 99.77%
    PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain.
  • HY-N2176
    S-(+)-Marmesin
    		Inhibitor 99.11%
    S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
  • HY-110399
    Cirsiliol
    		Inhibitor ≥99.0%
    Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
  • HY-N1942
    5-O-Demethylnobiletin
    		Inhibitor 99.93%
    5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush.
  • HY-N2056
    11-​Keto-​beta-​boswellic acid
    		Inhibitor 99.96%
    11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense.
  • HY-N2513
    β-Boswellic acid
    		Inhibitor 98.59%
    β-Boswellic acid is isolated from the gum resin of Boswellia serrata.
  • HY-U00156
    Lonapalene
    		Inhibitor 99.07%
    Lonapalene (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor.
  • HY-N2074
    Picrinine
    		Inhibitor 99.33%
    Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris.
  • HY-14164A
    Zileuton sodium
    		Inhibitor
    Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities.