2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cytochrome P450
  5. CYP3 Isoform
  6. CYP3 Inhibitor

CYP3 Inhibitor

CYP3 Inhibitors (50):

Cat. No. Product Name Effect Purity
  • HY-17356
    Fenofibrate
    		Inhibitor 99.99%
    Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM.
  • HY-B0105
    Ketoconazole
    		Inhibitor 99.86%
    Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-17508
    Clarithromycin
    		Inhibitor ≥98.0%
    Clarithromycin has a broad spectrum of antimicrobial activity.
  • HY-129993
    Gemfibrozil 1-O-β-glucuronide
    		Inhibitor 98.71%
    Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.
  • HY-14273
    Isavuconazole
    		Inhibitor 99.99%
    Isavuconazole (BAL-4815) is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi.
  • HY-152159
    CYP4Z1-IN-1
    		Inhibitor
    CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM.
  • HY-18063
    ML252
    		Inhibitor
    ML252 is a selective inhibitor of potassium channel, targeting to KCNQ2 channel (Kv7.2) (IC50=69 nM).
  • HY-148597
    FGFR-IN-10
    		Inhibitor
    FGFR-IN-10 is an orally active inhibitor of FGFR and Cytochrome P450 (CYPs).
  • HY-N0043
    Ginsenoside Rd
    		Inhibitor 98.02%
    Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells.
  • HY-17367A
    Atazanavir sulfate
    		Inhibitor 99.94%
    Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration.
  • HY-13600
    Clobetasol propionate
    		Inhibitor 99.85%
    Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC50 of 0.206 μM.
  • HY-108881
    Troleandomycin
    		Inhibitor ≥98.0%
    Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor.
  • HY-134772
    AS1810722
    		Inhibitor 98.56%
    AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM.
  • HY-N0692
    Schisandrol B
    		Inhibitor 99.57%
    Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects.
  • HY-N5011
    5,7-Dimethoxyflavone
    		Inhibitor 99.86%
    5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects.
  • HY-N0693
    Schisandrin A
    		Inhibitor 99.43%
    Schisandrin A inhibits CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively.
  • HY-N0893
    Tetrahydrocurcumin
    		Inhibitor 99.43%
    Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin.
  • HY-P0092
    Cecropin B
    		Inhibitor 98.07%
    Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic.
  • HY-14405A
    Casopitant mesylate
    		Inhibitor 99.84%
    Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist.
  • HY-N0598
    Ginsenoside F1
    		Inhibitor ≥99.0%
    Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.