1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Troleandomycin

Troleandomycin (Synonyms: Triacetyloleandomycin)

Cat. No.: HY-108881
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Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor.

For research use only. We do not sell to patients.

Troleandomycin Chemical Structure

Troleandomycin Chemical Structure

CAS No. : 2751-09-9

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5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor[1][2].

In Vitro

Troleandomycin markedly inhibits 6β-hydroxylation of testosterone, 25- and 26-hydroxylations of 5β-cholestane-3α,7α,12α-triol and 23R-, 24R-, 24S-, and 27-hydroxylations of 5β-cholestane-3α,7α,12α,25-tetrol in both recombinant CYP3A4 and microsomes, but IC50 values for microsomes are somewhat higher than those for recombinant CYP3A4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Troleandomycin markedly suppresses these microsomal side chain hydroxylations in both mouse and human livers in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD female rats[1].
Dosage: 500 mg/kg.
Administration: A single oral dose.
Result: Markedly elevated the Cmax and AUC0-6 of simvastatin by 9.5- and 10.2-fold, respectively.
Molecular Weight

813.97

Formula

C₄₁H₆₇NO₁₅

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

TroleandomycinTriacetyloleandomycinCytochrome P450CYPstonsillitisbronchitissinusitispneumoniap450Inhibitorinhibitorinhibit

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Troleandomycin
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