1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Furafylline

Furafylline 

Cat. No.: HY-107204 Purity: 99.86%
Handling Instructions

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.

For research use only. We do not sell to patients.

Furafylline Chemical Structure

Furafylline Chemical Structure

CAS No. : 80288-49-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 515 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

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Description

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.

IC50 & Target

IC50: 0.07 μM (human cytochrome P450IA2)[1]

In Vivo

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (48.03 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8425 mL 19.2123 mL 38.4246 mL
5 mM 0.7685 mL 3.8425 mL 7.6849 mL
10 mM 0.3842 mL 1.9212 mL 3.8425 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (8.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (8.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

260.25

Formula

C₁₂H₁₂N₄O₃

CAS No.

80288-49-9

SMILES

O=C1N(C2=C(N=C(C)N2)C(N1C)=O)CC3=CC=CO3

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.86%

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Furafylline
Cat. No.:
HY-107204
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Furafylline

Cat. No.: HY-107204