1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Furafylline

Furafylline 

Cat. No.: HY-107204 Purity: 99.86%
Handling Instructions

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.

For research use only. We do not sell to patients.

Furafylline Chemical Structure

Furafylline Chemical Structure

CAS No. : 80288-49-9

Size Price Stock Quantity
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM.

IC50 & Target

IC50: 0.07 μM (human cytochrome P450IA2)[1]

In Vivo

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.25

Formula

C₁₂H₁₂N₄O₃

CAS No.

80288-49-9

SMILES

O=C1N(C2=C(N=C(C)N2)C(N1C)=O)CC3=CC=CO3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (48.03 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8425 mL 19.2123 mL 38.4246 mL
5 mM 0.7685 mL 3.8425 mL 7.6849 mL
10 mM 0.3842 mL 1.9212 mL 3.8425 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (8.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (8.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.86%

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Keywords:

FurafyllineCytochrome P450CYPsInhibitorinhibitorinhibit

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Product Name:
Furafylline
Cat. No.:
HY-107204
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