2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

Related Products

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111329
    JGB1741
    		Inhibitor 99.37%
    JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research.
    JGB1741
  • HY-W020111
    7-Chloro-4-(piperazin-1-yl)quinoline
    		Inhibitor 98.63%
    7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively.
    7-Chloro-4-(piperazin-1-yl)quinoline
  • HY-B0879
    Suramin
    		Inhibitor
    Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor.Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.
    Suramin
  • HY-150727
    SIRT5 inhibitor 4
    		Inhibitor 98.37%
    SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively.
    SIRT5 inhibitor 4
  • HY-163676
    MI-217
    		Inhibitor 99.52%
    MI-217 is a potent SIRT3 inhibitor. MI-217 induces MDA-MB-231 apoptosis. MI-217 can be used in the study of breast cancer.
    MI-217
  • HY-RS12954
    Sirt7 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt7 Mouse Pre-designed siRNA Set A
  • HY-RS12953
    SIRT7 Human Pre-designed siRNA Set A
    		Inhibitor

    SIRT7 Human Pre-designed siRNA Set A contains three designed siRNAs for SIRT7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SIRT7 Human Pre-designed siRNA Set A
  • HY-151519
    SIRT2-IN-9
    		Inhibitor 99.45%
    SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.
    SIRT2-IN-9
  • HY-156781
    Sirtuin-1 inhibitor 1
    		Inhibitor 98.09%
    Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases.
    Sirtuin-1 inhibitor 1
  • HY-15452R
    Selisistat (Standard)
    		Inhibitor
    Selisistat (Standard) is the analytical standard of Selisistat. This product is intended for research and analytical applications. Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.
    Selisistat (Standard)
  • HY-155727
    Sirt1/2-IN-2
    		Inhibitor
    Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.
    Sirt1/2-IN-2
  • HY-148408
    SIRT2-IN-11
    		Inhibitor 99.94%
    SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers.
    SIRT2-IN-11
  • HY-118343
    AC-93253
    		Inhibitor 99.3%
    AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors.
    AC-93253
  • HY-147233
    MIND4-19
    		Inhibitor 99.93%
    MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease.
    MIND4-19
  • HY-RS12944
    Sirt3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt3 Mouse Pre-designed siRNA Set A
  • HY-155725
    Z26395438
    		Inhibitor 99.59%
    Z26395438 (compound 1) is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM.
    Z26395438
  • HY-RS12948
    Sirt5 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt5 Mouse Pre-designed siRNA Set A
  • HY-100591R
    SirReal2 (Standard)
    		Inhibitor
    SirReal2 (Standard) is the analytical standard of SirReal2 (HY-100591). This product is intended for research and analytical applications. SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration.
    SirReal2 (Standard)
  • HY-B0879AR
    Suramin sodium salt (Standard)
    		Inhibitor
    Suramin (sodium salt) (Standard) is the analytical standard of Suramin (sodium salt). This product is intended for research and analytical applications. Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.
    Suramin sodium salt (Standard)
  • HY-111303
    CHIC35
    		Inhibitor
    CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM). CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research.
    CHIC35
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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