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Sirt1/2-IN-2

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.

For research use only. We do not sell to patients.

  • Purity: 90%
  • CAS No.: 670267-73-9
  • Formula: C18H14N4O3S2
  • Molecular Weight:398.46
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Sirt1/2-IN-2 Chemical Structure
    Sirt1/2-IN-2 Chemical Structure
CAS No.: 670267-73-9
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  • Sirt1/2-IN-2 Chemical Structure
    Sirt1/2-IN-2 Chemical Structure
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