670267-73-9
670267-73-9
Chemical Structure
Sirt1/2-IN-2
- CAS No.: 670267-73-9
- Formula:C18H14N4O3S2
- Molecular Weight:398.46
InChIKey: DIHWMXSCKBJTOT-UHFFFAOYSA-N
SMILES: O=S(NC1=CC(SC2=NN=CN2)=C(C3=C1C=CC=C3)O)(C4=CC=CC=C4)=O
Biological Activity: Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].
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Sirt1/2-IN-2 | 90% | Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines. | ||||||||||||||||||||
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References
Keywords
