2. Stem Cell/Wnt Apoptosis Autophagy
  3. YAP Apoptosis Autophagy Photosensitizer
  4. Verteporfin

Verteporfin  (Synonyms: ベルテポルフィン; CL 318952)

製品番号: HY-B0146 純度: 98.15%
COA 取扱説明書 Technical Support

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 129497-78-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 152 在庫あり
Solution
10 mM * 1 mL in DMSO USD 152 在庫あり
Solid
5 mg $96 在庫あり
10 mg $144 在庫あり
25 mg $319 在庫あり
50 mg $552 在庫あり
100 mg $960 在庫あり
200 mg $1536 在庫あり
500 mg $3062 在庫あり
1 g $4900 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 266 publication(s) in Google Scholar

Other Forms of Verteporfin:

Verteporfin 関連抗体

Top Publications Citing Use of Products

顧客検証

WB
IHC
RT-PCR
Cell Proliferation/Viability Assay
IF

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Jan 13;15(1):202-226.  [Abstract]

    Verteporfin (0.5 μM; pretreatment for 4 hours followed by 30-minute treatment) inhibits norepinephrine (NE)- or dexmedetomidine (DEX)-induced YAP dephosphorylation (activated state) in AKP tumor cells, restores phosphorylation levels of LATS1 and YAP, and blocks ADRA2A/Gi-mediated YAP signaling pathway activation.

    Verteporfin purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Apr 1;21(1):238.  [Abstract]

    Verteporfin (13.9 µM; 10 µg/mL; 24 h) decreases the expression of YAP and CDX2 in NSCCs.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2023 Sep;30(9):2715-2727.  [Abstract]

    Verteporfin (0-5 µM; 24 h) decreases the viability of Ishikawa cells in a concentration-dependent manner (IC50 = 1.345 µM).

    Verteporfin purchased from MedChemExpress. Usage Cited in: Reprod Sci. 2023 Sep;30(9):2715-2727.  [Abstract]

    Verteporfin (0.5, 1, 2 µM) decreases the expression of anti-apoptotic marker B cell leukemia 2 (Bcl2), while increases the expression of pro-apoptotic protein Bcl2-associated X protein (Bax) in Ishikawa cells, in a concentration-dependent manner.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Jun;32(6):543-554.  [Abstract]

    Survival of mice with striatal GL261 tumor injection with or without RT, saline plus laser treatment, or Verteporfin (Visudyne; 2 mg/mL; 5 μL was injected into the cisterna magna; 15 min) plus laser treatment.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2022 Jul;25(7):849-864.  [Abstract]

    Verteporfin (1 µM)-treated animals exposed to 640 nm in the head exhibits less mrc1a+ cells in the brain compared to non-photoactivated control animals.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Oct 5;13(1):5871.  [Abstract]

    Mice are injected with either Verteporfin (VP; 100 mg/kg) or vehicle (corn oil) from the postnatal 7 days at 3-day intervals for 14 days. The immunohistochemical assay shows that the expression of TFRC and COX2 is higher in Bnc1tr/tr control mouse ovaries than in Bnc1+/+ control mouse ovaries. Intriguingly, VP treatment partially rescues TFRC and COX2 expression in Bnc1tr/tr mouse ovaries.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153.  [Abstract]

    The expression levels of Hippo-YAP signaling downstream regenerative genes (Ctgf, Ankrd1 and Cyr61) are effectively inhibited by Verteporfin (VP; 100 µM) compared to their expression in the blank control group.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153.  [Abstract]

    Compared to cell viability in the vehicle control group, Verteporfin (VP; 100 µM) markedly impairs cell viability assayed by JC-1 staining and CCK-8.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153.  [Abstract]

    Compared to cell viability in the vehicle control group, Verteporfin (VP; 100 µM) markedly impairs cell viability assayed by JC-1 staining and CCK-8.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Hepatology. 2021 Oct;74(4):2133-2153.  [Abstract]

    The protective effects of TNIP3 against cell inflammation and cell death were largely abolished by Verteporfin (VP; 100 µM) administration.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cell Res. 2020 Mar;30(3):229-243.  [Abstract]

    The representative images of dCLNs and sCLNs 2 weeks after striatal injection of GL261 or B16 cells into mice treated with Vehicle + Laser or =Verteporfin (Visudyne; 2 mg/mL; 5 μL was injected into the cisterna magna; 15 min) + Laser.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936.  [Abstract]

    Verteporfin displays a complete suppression of viral CPE at 0.31 µM. Viral N protein expression in infected Vero E6 cells was assessed by immunofluorescence.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936.  [Abstract]

    Protoporphyrin IX and Verteporfin effectively prevent SARS-CoV-2 infection in the mouse model expressing human ACE2. Much fewer cells expressed viral N protein in the Protoporphyrin IX and Verteporfin (20 µM) groups compared to the DMSO group.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936.  [Abstract]

    Verteporfin (0.31 µM) inhibits N protein expression in SARS-CoV-2-infected Vero E6 cells.​

    Verteporfin purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936.  [Abstract]

    Antiviral effect and cell cytotoxicity of protoporphyrin IX and verteporfin. The viral RNA production in the supernatant of infected Vero E6 cells was quantified with qRT-PCR. The value at each compound concentration was presented relative to that at zero compound concentration that was set as 100% (blue).

    Verteporfin purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2019 Sep 16;36(3):302-318.e7.  [Abstract]

    Combined treatment of GFAP-Ptch tumor cells with Verteporfin (VP; 24 hours) and CD532 additively decreases proliferation of ZIC1+ tumor cells relative to individual treatments.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2019 Jan 3;73(1):7-21.e7.  [Abstract]

    Control low metastatic MDA-MB-231 cells or cells overexpressing OTUB2-WT, pretreated with or without Verteporfin (VP, 10 µM) are intracardially injected into nude mice.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2019 Mar:107:29-40.  [Abstract]

    Col1a1 and α-SMA protein levels are analyzed in cells treated with VP.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Mol Immunol. 2019 Mar:107:29-40.  [Abstract]

    Col1a1 and α-SMA protein levels are analyzed in cells treated with VP.

    Verteporfin purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2018 Dec 11:12:489.  [Abstract]

    OECs are treated with vehicle (0.1% DMSO), Y27632 (10 μM) or verteporfin (5 μM) for 24 h and performed WB analysis.

    YAP アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

    • 生物活性

    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis[1]. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation[3].

    IC50 & Target

    YAP/TAZ-TEAD

     

    体外実験

    Verteporfin is specifically selected by PDX-cell screening. The concentrations to cause 50% growth inhibition (GI50) for PhLO, PhLH, and PhLK are 228 nM, 395 nM, and 538 nM, respectively, whereas GI50 for ALL-1, TCC-Y/sr, and NPhA1 are 3.93 μM, 2.11 μM, and 5.61 μM, respectively. GSH significantly reduces the sensitivity of 2 out of 3 PDX cells to verteporfin. Verteporfin reduces the mitochondrial membrane potential in PDX cells[1]. Verteporfin reduces the PTX-resistance on HCT-8/T cells by inhibiting YAP expression and combination therapy with verteporfin and NSC 125973 shows synergism on inhibition of YAP and cytotoxicity to HCT-8/T[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Verteporfin 関連抗体
    体内実験

    Verteporfin (10 mg/kg, c.s.c.) and BMS-354825 significantly reduces the leukemia cell ratio, and combined therapy further reduced the number of leukemia cells in the spleen[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    718.79

    分子式

    C41H42N4O8
    CAS 番号
    Appearance

    Solid

    Color

    Brown to black

    SMILES

    C[C@]1(/C2=C/C(N3)=C4C)C(C(/C=C(C(C)=C/5C=C)\NC5=C/C6=N/C(C(CCC(OC)=O)=C6C)=C\C3=C4CCC(O)=O)=N2)=CC=C(C(OC)=O)[C@H]1C(OC)=O.C[C@]7(/C8=C/C(N9)=C%10C)C(C(/C=C(C(C)=C/%11C=C)\NC%11=C/C%12=N/C(C(CCC(O)=O)=C%12C)=C\C9=C%10CCC(OC)=O)=N8)=CC=C(C(OC)=O)[C@H]7C(OC)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : 50 mg/mL (69.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    DMF : 10 mg/mL (13.91 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3912 mL 6.9561 mL 13.9123 mL
    5 mM 0.2782 mL 1.3912 mL 2.7825 mL
    10 mM 0.1391 mL 0.6956 mL 1.3912 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

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    濃度 （終了）

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    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 1 mg/mL (1.39 mM); Suspended solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 10 mg/mL (13.91 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.58%

    COA (258 KB) HNMR (213 KB) RP-HPLC (208 KB)

    取扱説明書 (2659 KB)
    参考文献
    細胞実験
    [1]

    PDX cells co-cultured with S17 cells are treated with 16 combinations of verteporfin (60 nM, 120 nM, 180 nM, and 240 nM) and BMS-354825 (12 nM, 24 nM, 36 nM, and 48 nM). The viabilities of cells treated with each combination are measured after 48 h using FACS Aria flow cytometer. In order to estimate drug interaction between verteporfin and BMS-354825, a normalized isobologram and fraction affectedcombination index (CI) plot are made using CompuSyn software. CI values greater than 1.0 indicated antagonistic effects, equal to 1.0 additive effects, and below 1.0 synergistic effects.

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    動物実験
    [1]

    Mice: PhLO cells (1.0×107/mouse) are injected intravenously into 6-week-old male NOG mice, which are then treated with vehicle, verteporfin (140 mg/kg/day), BMS-354825 (20 mg/kg/day), and a combination of these drugs from days 22 to 28. Verteporfin is administered by continuous subcutaneous infusion (c.s.c.) using Alzet osmotic pumps. An intraperitoneal injection (i.p.) is performed for BMS-354825. All mice are sacrificed on day 28 and the chimerism of leukemia cells is investigated by flow cytometer using an anti-human CD19 antibody and antimouse CD45 antibody. Blood concentrations of verteporfin are calculated by LCMS-2020.

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMF / DMSO 1 mM 1.3912 mL 6.9561 mL 13.9123 mL 34.7807 mL
    5 mM 0.2782 mL 1.3912 mL 2.7825 mL 6.9561 mL
    10 mM 0.1391 mL 0.6956 mL 1.3912 mL 3.4781 mL
    DMSO 15 mM 0.0927 mL 0.4637 mL 0.9275 mL 2.3187 mL
    20 mM 0.0696 mL 0.3478 mL 0.6956 mL 1.7390 mL
    25 mM 0.0556 mL 0.2782 mL 0.5565 mL 1.3912 mL
    30 mM 0.0464 mL 0.2319 mL 0.4637 mL 1.1594 mL
    40 mM 0.0348 mL 0.1739 mL 0.3478 mL 0.8695 mL
    50 mM 0.0278 mL 0.1391 mL 0.2782 mL 0.6956 mL
    60 mM 0.0232 mL 0.1159 mL 0.2319 mL 0.5797 mL
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    Verteporfin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Verteporfin129497-78-5CL 318952CL318952CL-318952YAPApoptosisAutophagyPhotosensitizerYes-associated proteinInhibitorinhibitorinhibit

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    製品名:
    Verteporfin
    製品番号:
    HY-B0146
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