2. Cell Cycle/DNA Damage
  3. CDK
  4. Rogocekib

Rogocekib  (Synonyms: CTX-712)

製品番号: HY-144875 純度: 98.15%
COA 取扱説明書 Technical Support

Rogocekib is an orally effective CLK 2 inhibitor, with an IC50 of 1.4 nM, showing anti-tumor activity.

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Rogocekib

Rogocekib 構造式

CAS 番号 : 2144751-78-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1265 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1265 在庫あり
Solid
1 mg $523 在庫あり
5 mg $1150 在庫あり
10 mg $1800 在庫あり
25 mg $3240 在庫あり
50 mg $4860 在庫あり
100 mg $7290 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Rogocekib 関連抗体

Top Publications Citing Use of Products

CDK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Rogocekib is an orally effective CLK 2 inhibitor, with an IC50 of 1.4 nM, showing anti-tumor activity[1][2].

IC50 & Target

CLK2

1.4 nM (IC50)

体外実験

Rogocekib has a strong inhibitory effect on the proliferation of human myeloid K562 and MV-4-11 cells, with an IC50 of 0.15 and 0.036 μM, respectively. For primary acute myeloid leukemia (AML) cells, the IC50 is 0.078 μM, demonstrating its anti-leukemia activity[1].
Rogocekib inhibits the phosphorylation of various serine/arginine (SR) proteins, including SRSF3/4/6, which can interact with SRSF2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rogocekib 関連抗体
体内実験

Rogocekib (6.25-12.5 mg/kg, orally, for two weeks) reduces tumor size and increases survival rates in mice with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse models of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). [1]
Dosage: 6.25, 12.5 mg/kg, two weeks
Administration: Oral
Result: Showed two cases of SRSF2 mutations, P95H and P95L observed with significant dose-dependent effects. P95H reduced tumor volume and improved survival rates in the SRSF2 P95L model.
臨床実験
分子量

408.39

分子式

C19H17FN8O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CC1=NC2=NC=C(C3=C4C(OC)=NC=NN4C=C3)C=C2N1CC5=NN=C([C@H](F)C)O5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 25 mg/mL (61.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4486 mL 12.2432 mL 24.4864 mL
5 mM 0.4897 mL 2.4486 mL 4.8973 mL
10 mM 0.2449 mL 1.2243 mL 2.4486 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.12 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.12 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4486 mL 12.2432 mL 24.4864 mL 61.2160 mL
5 mM 0.4897 mL 2.4486 mL 4.8973 mL 12.2432 mL
10 mM 0.2449 mL 1.2243 mL 2.4486 mL 6.1216 mL
15 mM 0.1632 mL 0.8162 mL 1.6324 mL 4.0811 mL
20 mM 0.1224 mL 0.6122 mL 1.2243 mL 3.0608 mL
25 mM 0.0979 mL 0.4897 mL 0.9795 mL 2.4486 mL
30 mM 0.0816 mL 0.4081 mL 0.8162 mL 2.0405 mL
40 mM 0.0612 mL 0.3061 mL 0.6122 mL 1.5304 mL
50 mM 0.0490 mL 0.2449 mL 0.4897 mL 1.2243 mL
60 mM 0.0408 mL 0.2041 mL 0.4081 mL 1.0203 mL
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Rogocekib Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rogocekib2144751-78-8CTX-712CTX712CTX 712CDKCyclin dependent kinaseCdc2-like kinaseCLKCancer survivalCancer cell growthInhibitorinhibitorinhibit

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製品名:
Rogocekib
製品番号:
HY-144875
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