Dihydrolanosterol

Art. -Nr.: HY-122410 Reinheit: 99.72%: Data Sheet
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Dihydrolanosterol is a subtrate of CYP51 and a cholesterol biosynthesis inhibitor..

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Dihydrolanosterol Chemische Struktur

CAS. Nr. : 79-62-9

Größe	Verfügbarkeit	Menge
Solution
10 mM * 1 mL in Ethanol	Auf Lager	Estimated Time of Arrival: December 31
Solid
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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500 mg	Angebot einholen

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Based on 1 publication(s) in Google Scholar

Other Forms of Dihydrolanosterol:

Dihydrolanosterol-d₇ In-stock
Dihydrolanosterol (Standard) Angebot einholen

1 Publications Citing Use of MCE Dihydrolanosterol

•Cell Chem Biol. 2024 May 16;31(5):920-931.e6. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

Dihydrolanosterol is a subtrate of CYP51 and a cholesterol biosynthesis inhibitor.^[1].

IC₅₀ & Target

CYP51

Molekulargewicht

428.73

Formel

C₃₀H₅₂O

CAS. Nr.

79-62-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12C3=C(CC[C@@]1([C@@](CC2)([H])[C@H](C)CCCC(C)C)C)[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC3)C

Structure Classification

Initial Source

Microorganisms

Endogenous metabolite

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 12.5 mg/mL (29.16 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3325 mL	11.6624 mL	23.3247 mL
5 mM	0.4665 mL	2.3325 mL	4.6649 mL
10 mM	0.2332 mL	1.1662 mL	2.3325 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (2.92 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (2.92 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.72%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (247 KB) HNMR (276 KB) RP-HPLC (233 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochim Biophys Acta. 2007;1770(3):467-477. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	2.3325 mL	11.6624 mL	23.3247 mL	58.3118 mL
	5 mM	0.4665 mL	2.3325 mL	4.6649 mL	11.6624 mL
	10 mM	0.2332 mL	1.1662 mL	2.3325 mL	5.8312 mL
	15 mM	0.1555 mL	0.7775 mL	1.5550 mL	3.8875 mL
	20 mM	0.1166 mL	0.5831 mL	1.1662 mL	2.9156 mL
	25 mM	0.0933 mL	0.4665 mL	0.9330 mL	2.3325 mL